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AB160086

Recombinant Human FCN3 protein (GST tag N-Terminus)

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(1 Publication)

Recombinant Human FCN3 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 288 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

FCNH, HAKA1, FCN3, Ficolin-3, Collagen/fibrinogen domain-containing lectin 3 p35, Collagen/fibrinogen domain-containing protein 3, H-ficolin, Hakata antigen

1 Images
SDS-PAGE - Recombinant Human FCN3 protein (GST tag N-Terminus) (AB160086)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human FCN3 protein (GST tag N-Terminus) (AB160086)

ab160086 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

O75636

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Recombinant Human BS69 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human BS69 protein (GST tag N-Terminus) (AB161146)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MDLLWILPSLWLLLLGGPACLKTQEHPSCPGPRELEASKVVLLPSCPGAPGSPGEKGAPGPQGPPGPPGKMGPKGEPGPRNCRELLSQGATLSGWYHLCLPEGRALPVFCDMDTEGGGWLVFQRRQDGSVDFFRSWSSYRAGFGNQESEFWLGNENLHQLTLQGNWELRVELEDFNGNRTFAHYATFRLLGEVDHYQLALGKFSEGTAGDSLSLHSGRPLTTYDADHDSSNSNCAVIVHGAWWYASCYRSNLNGRYAVSEAAAHKYGIDWASGRGVGHPYRRVRMMLR","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":288,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"O75636","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FCN3 also known as ficolin-3 is a multifunctional protein recognized for its role in the immune system. Ficolin-3 is approximately 35 kDa in mass and is mainly expressed in the liver though it can also be found in various other tissues such as the spleen and lungs. It belongs to the ficolin family of proteins which are involved in innate immunity. The protein features a collagen-like domain and a fibrinogen-like domain facilitating its binding to sugars on microbial surfaces.
Biological function summary

Ficolin-3 acts as an essential player in the immune response contributing to pathogen recognition and clearance. It forms a complex with other components to activate the complement pathway particularly the lectin pathway. Ficolin-3 binds to carbohydrate patterns on the surface of pathogens leading to opsonization and clearance. This activity highlights its function as a defense mechanism against infections and its role in recognizing altered cells.

Pathways

Ficolin-3 facilitates the activation of the lectin complement pathway. This pathway is important for innate immune defense and involves several other proteins including mannose-binding lectin (MBL) and MASP-2 which are connected with ficolin-3 in mediating complement activation. The engagement of ficolin-3 in this pathway highlights its importance in identifying and eliminating pathogens effectively.

Mutations or deficiencies in the function of ficolin-3 are associated with an increased risk of infections and autoimmune diseases such as systemic lupus erythematosus (SLE). The protein's role in immune defense makes it a critical factor in maintaining a balanced immune response. Additionally related proteins like MBL can also influence the progression or predisposition to these conditions further emphasizing the interconnectedness of ficolin-3 within immune regulatory networks.
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Specifications

Form

Liquid

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General info

Function

Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed : 11907111, PubMed : 15804047, PubMed : 17215869, PubMed : 26133042). Specifically recognizes and binds carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway (PubMed : 15804047, PubMed : 17215869, PubMed : 26133042). Specifically binds N-Acetylglucosamine (GlcNAc,) GalNAc (N-acetylgalactosamine) and D-fucose on the surface of pathogens, as well as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota (PubMed : 17215869).

Sequence similarities

Belongs to the ficolin lectin family.

Post-translational modifications

The N-terminus is blocked.

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Product protocols

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Target data

Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed : 11907111, PubMed : 15804047, PubMed : 17215869, PubMed : 26133042). Specifically recognizes and binds carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway (PubMed : 15804047, PubMed : 17215869, PubMed : 26133042). Specifically binds N-Acetylglucosamine (GlcNAc,) GalNAc (N-acetylgalactosamine) and D-fucose on the surface of pathogens, as well as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota (PubMed : 17215869).
See full target information FCN3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Acta diabetologica 52:1103-12 PubMed26259496

2015

Early second-trimester plasma protein profiling using multiplexed isobaric tandem mass tag (TMT) labeling predicts gestational diabetes mellitus.

Applications

WB

Species

Human

Chun Zhao,Fuqiang Wang,Ping Wang,Hongjuan Ding,Xiaoyan Huang,Zhonghua Shi
View all publications
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