Recombinant Human FCN3 protein is a Human Full Length protein, in the 1 to 288 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Images
Publications
Filter by
- Acta diabetologica 52:1103-122015Early second-trimester plasma protein profiling using multiplexed isobaric tandem mass tag (TMT) labeling predicts gestational diabetes mellitus.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
M D L L W I L P S L W L L L L G G P A C L K T Q E H P S C P G P R E L E A S K V V L L P S C P G A P G S P G E K G A P G P Q G P P G P P G K M G P K G E P G P R N C R E L L S Q G A T L S G W Y H L C L P E G R A L P V F C D M D T E G G G W L V F Q R R Q D G S V D F F R S W S S Y R A G F G N Q E S E F W L G N E N L H Q L T L Q G N W E L R V E L E D F N G N R T F A H Y A T F R L L G E V D H Y Q L A L G K F S E G T A G D S L S L H S G R P L T T Y D A D H D S S N S N C A V I V H G A W W Y A S C Y R S N L N G R Y A V S E A A A H K Y G I D W A S G R G V G H P Y R R V R M M L R
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota.
Alternative names
FCNH, HAKA1, FCN3, Ficolin-3, Collagen/fibrinogen domain-containing lectin 3 p35, Collagen/fibrinogen domain-containing protein 3, Hakata antigen
Recommended products
Recombinant Human FCN3 protein is a Human Full Length protein, in the 1 to 288 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- O75636-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M D L L W I L P S L W L L L L G G P A C L K T Q E H P S C P G P R E L E A S K V V L L P S C P G A P G S P G E K G A P G P Q G P P G P P G K M G P K G E P G P R N C R E L L S Q G A T L S G W Y H L C L P E G R A L P V F C D M D T E G G G W L V F Q R R Q D G S V D F F R S W S S Y R A G F G N Q E S E F W L G N E N L H Q L T L Q G N W E L R V E L E D F N G N R T F A H Y A T F R L L G E V D H Y Q L A L G K F S E G T A G D S L S L H S G R P L T T Y D A D H D S S N S N C A V I V H G A W W Y A S C Y R S N L N G R Y A V S E A A A H K Y G I D W A S G R G V G H P Y R R V R M M L R
- Accession
- O75636
- Protein length
- Full Length
- Amino acids
- 1 to 288
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota.
- Sequence similarities
Belongs to the ficolin lectin family.
- Post-translational modifications
The N-terminus is blocked.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
FCN3 also known as ficolin-3 is a multifunctional protein recognized for its role in the immune system. Ficolin-3 is approximately 35 kDa in mass and is mainly expressed in the liver though it can also be found in various other tissues such as the spleen and lungs. It belongs to the ficolin family of proteins which are involved in innate immunity. The protein features a collagen-like domain and a fibrinogen-like domain facilitating its binding to sugars on microbial surfaces.
- Biological function summary
Ficolin-3 acts as an essential player in the immune response contributing to pathogen recognition and clearance. It forms a complex with other components to activate the complement pathway particularly the lectin pathway. Ficolin-3 binds to carbohydrate patterns on the surface of pathogens leading to opsonization and clearance. This activity highlights its function as a defense mechanism against infections and its role in recognizing altered cells.
- Pathways
Ficolin-3 facilitates the activation of the lectin complement pathway. This pathway is important for innate immune defense and involves several other proteins including mannose-binding lectin (MBL) and MASP-2 which are connected with ficolin-3 in mediating complement activation. The engagement of ficolin-3 in this pathway highlights its importance in identifying and eliminating pathogens effectively.
- Associated diseases and disorders
Mutations or deficiencies in the function of ficolin-3 are associated with an increased risk of infections and autoimmune diseases such as systemic lupus erythematosus (SLE). The protein's role in immune defense makes it a critical factor in maintaining a balanced immune response. Additionally related proteins like MBL can also influence the progression or predisposition to these conditions further emphasizing the interconnectedness of ficolin-3 within immune regulatory networks.
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
SDS-PAGE - Recombinant Human FCN3 protein (ab160086)
ab160086 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com