Recombinant Human FCRL3 protein (GST tag N-Terminus)
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Recombinant Human FCRL3 protein (GST tag N-Terminus) is a Human Fragment protein, in the 625 to 723 aa range, expressed in Wheat germ, suitable for ELISA, WB.
View Alternative Names
CD307c, FCRH3, IFGP3, IRTA3, SPAP2, FCRL3, Fc receptor-like protein 3, FcR-like protein 3, FcRL3, Fc receptor homolog 3, IFGP family protein 3, Immune receptor translocation-associated protein 3, MAIA, SH2 domain-containing phosphatase anchor protein 2, FcRH3, hIFGP3
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human FCRL3 protein (GST tag N-Terminus) (AB165072)
ab165072 on a 12.5% SDS-PAGE stained with Coomassie Blue.
Complementary Products
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
FCRL3 acts in regulating immune cell activation and differentiation. It influences the balance of auto-reactive and protective immune responses. FCRL3 does not form multimeric complexes but interacts with other immune receptors and signaling proteins. By modulating signaling pathways it impacts processes such as antibody production cellular proliferation and cytokine release. The protein contributes to maintaining immune homeostasis and preventing excessive inflammatory responses.
Pathways
FCRL3 engages in immune signaling cascades notably the B cell receptor (BCR) pathway and the T cell receptor (TCR) pathway. These pathways are central to adaptive immunity involving receptor signaling and subsequent cell activation. FCRL3 interacts with other proteins such as SYK and SHP-1 which mediate downstream signaling events in these pathways. This modulation is important for the fine-tuning of adaptive immune responses influencing immunity against pathogens and tolerance towards self-antigens.
Specifications
Form
Liquid
General info
Function
Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells (PubMed : 23857366). Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases. Inhibits cell tyrosine phosphorylation, calcium mobilization and activation-induced cell death induced through BCR signaling (PubMed : 19843936). Regulatory T-cells expressing FCRL3 exhibit a memory phenotype, are relatively nonresponsive to antigenic stimulation in presence of IL2 and have reduced capacity to suppress the proliferation of effector T-cells (PubMed : 19494275, PubMed : 20190142). Acts as a human-specific epitope on the cell surface of oocytes (oolemma) and plays a role during sperm-egg adhesion and fusion (PubMed : 36070373). Interacts with the IZUMO1-IZUMO1R/JUNO sperm-egg complex and replaces IZUMO1R/JUNO as IZUMO1 receptor during fertilization, thereby permitting species-specific gamete fusion (PubMed : 36070373).
Post-translational modifications
Phosphorylated on cytoplasmic tyrosines; required for interaction with protein tyrosine phosphatases and protein tyrosine kinases.
Target data
Product promise
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