Recombinant Human FCRL6 protein (His tag) is a Human Fragment protein, in the 20 to 307 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
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Key facts
- Purity
>90% SDS-PAGE
- Expression system
Escherichia coli
- Tags
His tag N-Terminus
- Applications
SDS-PAGE
- Biologically active
No
Amino acid sequence
L Y L Q A W P N P V F E G D A L T L R C Q G W K N T P L S Q V K F Y R D G K F L H F S K E N Q T L S M G A A T V Q S R G Q Y S C S G Q V M Y I P Q T F T Q T S E T A M V Q V Q E L F P P P V L S A I P S P E P R E G S L V T L R C Q T K L H P L R S A L R L L F S F H K D G H T L Q D R G P H P E L C I P G A K E G D S G L Y W C E V A P E G G Q V Q K Q S P Q L E V R V Q A P V S R P V L T L H H G P A D P A V G D M V Q L L C E A Q R G S P P I L Y S F Y L D E K I V G N H S A P C G G T T S L L F P V K S E Q D A G N Y S C E A E N S V S R E R S E P K K L S L K G S Q V L F T P A S N W
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Acts as a MHC class II receptor (PubMed:20519654). When stimulated on its own, does not play a role in cytokine production or the release of cytotoxic granules by NK cells and cytotoxic CD8(+) T cells (PubMed:17213291, PubMed:18991291). Does not act as an Fc receptor (PubMed:18991291).
Alternative names
Fc receptor-like protein 6, FcR-like protein 6, FcRL6, Fc receptor homolog 6, IFGP6, FcRH6, FCRL6, FCRH6
Recommended products
Recombinant Human FCRL6 protein (His tag) is a Human Fragment protein, in the 20 to 307 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
Key facts
- Purity
>90% SDS-PAGE
- Expression system
Escherichia coli
- Tags
His tag N-Terminus
- Applications
SDS-PAGE
- Biologically active
No
- Accession
- Q6DN72-1
- Animal free
No
- Species
Human
- Concentration
- Storage buffer
pH: 7.2 - 7.4
Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)
Sequence info
Amino acid sequence
L Y L Q A W P N P V F E G D A L T L R C Q G W K N T P L S Q V K F Y R D G K F L H F S K E N Q T L S M G A A T V Q S R G Q Y S C S G Q V M Y I P Q T F T Q T S E T A M V Q V Q E L F P P P V L S A I P S P E P R E G S L V T L R C Q T K L H P L R S A L R L L F S F H K D G H T L Q D R G P H P E L C I P G A K E G D S G L Y W C E V A P E G G Q V Q K Q S P Q L E V R V Q A P V S R P V L T L H H G P A D P A V G D M V Q L L C E A Q R G S P P I L Y S F Y L D E K I V G N H S A P C G G T T S L L F P V K S E Q D A G N Y S C E A E N S V S R E R S E P K K L S L K G S Q V L F T P A S N W
- Accession
- Protein length
Fragment
- Predicted molecular weight
35.7 kDa
- Amino acids
20 to 307
- Nature
Recombinant
- Tags
His tag N-Terminus
Specifications
- Form
Liquid
General info
- Function
Acts as a MHC class II receptor (PubMed:20519654). When stimulated on its own, does not play a role in cytokine production or the release of cytotoxic granules by NK cells and cytotoxic CD8(+) T cells (PubMed:17213291, PubMed:18991291). Does not act as an Fc receptor (PubMed:18991291).
- Post-translational modifications
Phosphorylated on Tyr residues. Tyrosine phosphorylation induces association with phosphatase PTPN11, PTPN6, INPP5D, INPPL1 and GRB2.
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage conditions
-20°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
FCRL6 also known as Fc receptor-like protein 6 is a transmembrane receptor expressed primarily on cytotoxic T cells and NK cells. This protein has a mass of approximately 55 kDa. It is predominantly expressed in immune tissues such as the spleen and tonsils and its expression is mainly found in T cell subsets. FCRL6 contains an immunoglobulin-like extracellular domain that plays an important role in the immune cell interactions.
- Biological function summary
FCRL6 is involved in regulating immune response and cytotoxic activity. This protein interacts with MHC class II molecules indicating its potential role in antigen presentation and immune system modulation. FCRL6 does not typically form part of a larger protein complex but it may engage with other cell surface molecules for its biological function.
- Pathways
FCRL6 participates in immune signaling pathways that regulate T cell and NK cell activation. These pathways often involve interactions driven by integrin and non-integrin proteins that modulate immune effector functions. Related proteins in the pathway include other members of the Fc receptor-like family which exhibit varying roles in immune modulation and maintenance of immune tolerance.
- Associated diseases and disorders
FCRL6 has been associated with autoimmune conditions and certain cancers. In autoimmune diseases such as rheumatoid arthritis dysregulation of FCRL6 expression has been noted impacting T cell activity. In some cancers irregular FCRL6 expression has been linked to altered immune cell function. Additionally FCRL6's interaction with other immune regulatory proteins such as PD-1 further connects it to cancer immunology and potential therapeutic targeting.
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1 product image
SDS-PAGE - Recombinant Human FCRL6 protein (His tag) (ab225642)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis of ab225642 with 5% enrichment gel and 15% separation gel.
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