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AB225642

Recombinant Human FCRL6 protein (His tag)

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Recombinant Human FCRL6 protein (His tag) is a Human Fragment protein, in the 20 to 307 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

FCRH6, FCRL6, Fc receptor-like protein 6, FcR-like protein 6, FcRL6, Fc receptor homolog 6, IFGP6, FcRH6

1 Images
SDS-PAGE - Recombinant Human FCRL6 protein (His tag) (AB225642)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human FCRL6 protein (His tag) (AB225642)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis of ab225642 with 5% enrichment gel and 15% separation gel.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q6DN72

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"LYLQAWPNPVFEGDALTLRCQGWKNTPLSQVKFYRDGKFLHFSKENQTLSMGAATVQSRGQYSCSGQVMYIPQTFTQTSETAMVQVQELFPPPVLSAIPSPEPREGSLVTLRCQTKLHPLRSALRLLFSFHKDGHTLQDRGPHPELCIPGAKEGDSGLYWCEVAPEGGQVQKQSPQLEVRVQAPVSRPVLTLHHGPADPAVGDMVQLLCEAQRGSPPILYSFYLDEKIVGNHSAPCGGTTSLLFPVKSEQDAGNYSCEAENSVSRERSEPKKLSLKGSQVLFTPASNW","proteinLength":"Fragment","predictedMolecularWeight":"35.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":307,"aminoAcidStart":20,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q6DN72","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FCRL6 also known as Fc receptor-like protein 6 is a transmembrane receptor expressed primarily on cytotoxic T cells and NK cells. This protein has a mass of approximately 55 kDa. It is predominantly expressed in immune tissues such as the spleen and tonsils and its expression is mainly found in T cell subsets. FCRL6 contains an immunoglobulin-like extracellular domain that plays an important role in the immune cell interactions.
Biological function summary

FCRL6 is involved in regulating immune response and cytotoxic activity. This protein interacts with MHC class II molecules indicating its potential role in antigen presentation and immune system modulation. FCRL6 does not typically form part of a larger protein complex but it may engage with other cell surface molecules for its biological function.

Pathways

FCRL6 participates in immune signaling pathways that regulate T cell and NK cell activation. These pathways often involve interactions driven by integrin and non-integrin proteins that modulate immune effector functions. Related proteins in the pathway include other members of the Fc receptor-like family which exhibit varying roles in immune modulation and maintenance of immune tolerance.

FCRL6 has been associated with autoimmune conditions and certain cancers. In autoimmune diseases such as rheumatoid arthritis dysregulation of FCRL6 expression has been noted impacting T cell activity. In some cancers irregular FCRL6 expression has been linked to altered immune cell function. Additionally FCRL6's interaction with other immune regulatory proteins such as PD-1 further connects it to cancer immunology and potential therapeutic targeting.
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Specifications

Form

Liquid

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General info

Function

Acts as a MHC class II receptor (PubMed : 20519654). When stimulated on its own, does not play a role in cytokine production or the release of cytotoxic granules by NK cells and cytotoxic CD8(+) T cells (PubMed : 17213291, PubMed : 18991291). Does not act as an Fc receptor (PubMed : 18991291).

Post-translational modifications

Phosphorylated on Tyr residues. Tyrosine phosphorylation induces association with phosphatase PTPN11, PTPN6, INPP5D, INPPL1 and GRB2.

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Product protocols

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Target data

Acts as a MHC class II receptor (PubMed : 20519654). When stimulated on its own, does not play a role in cytokine production or the release of cytotoxic granules by NK cells and cytotoxic CD8(+) T cells (PubMed : 17213291, PubMed : 18991291). Does not act as an Fc receptor (PubMed : 18991291).
See full target information FCRL6
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