Recombinant Human FDCSP protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein FDCSP known as Follicular Dendritic Cell Secreted Protein possesses a molecular mass of approximately 8.6 kDa. Researchers find FDCSP mainly expressed in follicular dendritic cells within lymphoid tissues. This protein is small but it holds significant importance in the immune system's architecture. Due to its precise expression pattern FDCSP serves as a useful marker in studies of lymphoid structures and functions.

Biological function summary

FDCSP plays an important role in the organization of lymphoid follicles and the maintenance of the lymph node microenvironment. It associates with the extracellular matrix supporting communication between dendritic cells and other immune cells. Although not part of a large complex FDCSP influences the network surrounding follicular dendritic cells. This role aids in antigen presentation and lymphocyte activation key elements in the adaptive immune response.

Pathways

FDCSP connects closely with immune response pathways particularly those regulating antigen presentation and lymphocyte activation. It interacts indirectly with proteins involved in the complement system such as C3 and with receptors on B-lymphocytes. This interaction aids in creating a robust immune response by enhancing antigen presentation and promoting B cell maturation within germinal centers.

FDCSP draws attention because of its involvement in immune-related conditions like autoimmune diseases and lymphomas. Its expression levels may change in diseases such as follicular lymphoma impacting the disease progression. Connections to other proteins such as BAFF (B-cell activating factor) highlight FDCSP's role in B-cell related disorders. Understanding FDCSP's behavior in these contexts helps to shed light on its potential as a diagnostic or therapeutic target.