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AB156316

Recombinant Human FGF17 protein (denatured) (His tag N-Terminus)

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Recombinant Human FGF17 protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 23 to 216 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

UNQ161/PRO187, FGF17, Fibroblast growth factor 17, FGF-17

1 Images
SDS-PAGE - Recombinant Human FGF17 protein (denatured) (His tag N-Terminus) (AB156316)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human FGF17 protein (denatured) (His tag N-Terminus) (AB156316)

15% SDS-PAGE analysis of ab156316 (3μg).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

O60258

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMTQGENHPSPNFNQYVRDQGAMTDQLSRRQIREYQLYSRTSGKHVQVTGRRISATAEDGNKFAKLIVETDTFGSRVRIKGAESEKYICMNKRGKLIGKPSGKSKDCVFTEIVLENNYTAFQNARHEGWFMAFTRQGRPRQASRSRQNQREAHFIKRLYQGQLPFPNHAEKQKQFEFVGSAPTRRTKRTRRPQPLT","proteinLength":"Full Length","predictedMolecularWeight":"25.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":216,"aminoAcidStart":23,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O60258","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Fibroblast Growth Factor 17 (FGF17) is a member of the fibroblast growth factor family and is also known as FGF-17. This protein has a molecular mass of approximately 22 kDa. You may find FGF17 expressed in various tissues including the brain particularly in the cerebellum where it plays significant roles in development. The protein functions as a signaling molecule engaging with fibroblast growth factor receptors (FGFRs) to initiate a cascade of cellular events.
Biological function summary

FGF17 influences processes such as cell proliferation differentiation and neural development. It often operates as part of a larger fibroblast growth factor signaling complex that includes other growth factors and their receptors. This complex formation is essential for the fine-tuning of signal transduction events. By interacting with multiple FGFRs FGF17 contributes to the regulation of embryonic development and tissue regeneration.

Pathways

FGF17 is a part of the MAPK/ERK signaling pathway which plays a significant role in transmitting signals from surface receptors to the DNA in the nucleus. This pathway engages with other proteins such as FGFR1 and FGFR2 facilitating processes like cell growth and division. FGF17 also participates in the PI3K/AKT pathway which is important for cell survival and metabolism indicating its broad impact on important cellular functions.

FGF17 has connections to skeletal disorders such as craniosynostosis a condition where the bones of the skull fuse prematurely. Mutations or dysregulation in FGF17 expression can contribute to this disorder. Additionally FGF17 alterations have an association with cancers including prostate cancer where increased expression leads to uncontrolled cell growth. FGF17 interacts with proteins such as FGFR2 in these contexts illustrating its role in pathological development.
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Specifications

Form

Liquid

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General info

Function

Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development.

Sequence similarities

Belongs to the heparin-binding growth factors family.

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Product protocols

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Target data

Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development.
See full target information FGF17
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