Recombinant Human FGF22 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FGF22 also known as Fibroblast Growth Factor 22 is a signaling protein that belongs to the fibroblast growth factor family. It has a molecular mass of approximately 22 kDa. FGF22 is primarily expressed in specific areas of the brain such as the hippocampus and cerebellum as well as in skin tissue. Its mechanism involves binding to FGF receptors which results in the activation of downstream signaling cascades that influence various cellular processes.

Biological function summary

FGF22 plays an important role in nervous system development by promoting the differentiation and maturation of neurons. FGF22 also participates in the formation of synapses contributing to neural connectivity. It does not typically function as part of a complex but acts directly through interactions with its receptor partners. Its expression in peripheral tissues suggests a role in wound healing and skin regeneration.

Pathways

This protein is an integral component of the FGF signaling pathway which is essential for numerous developmental and physiological processes. Through this pathway FGF22 plays a prominent role in synaptic organization and plasticity. It interacts with proteins such as FGFR1 and FGFR2 which are important in mediating its activity in neuronal tissue. The MAPK/ERK pathway is another significant pathway through which FGF22 exerts its effects on cell proliferation and differentiation.

Dysregulation of FGF22 has been linked to neurological conditions such as epilepsy and major depressive disorder. Abnormal FGF22 signaling can alter synaptic functions and impair neuronal communication contributing to these conditions. Additionally FGF22's relationship with other growth factors like NGF (nerve growth factor) enhances its influence on neuronal health and pathology making it a potential target in therapeutic strategies aimed at treating these disorders.