Recombinant human FGF6 protein (Active)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FGF6 also known as Fibroblast Growth Factor 6 is a protein that plays an important role in muscle development and repair. It has a molecular mass of approximately 23 kDa. Researchers find FGF6 to be expressed mainly in skeletal muscle tissue indicating its specific role in muscular activities. Apart from muscle tissues evidence also suggests its expression in certain brain areas contributing to its diverse functions.

Biological function summary

FGF6 belongs to the fibroblast growth factor family which is essential for cell proliferation and differentiation. It significantly influences muscle regeneration and repair after injury. Though FGF6 acts independently it often interacts with FGF receptors on the cell surface to stimulate cellular responses. Its activity does not limit to isolated action but integrates well with complex cellular processes important for muscle tissue maintenance.

Pathways

FGF6 plays a role in signaling cascades such as the MAPK/ERK pathway that regulates various cellular activities like proliferation and differentiation. This pathway involves important interactions with proteins like FGFR1 a receptor that mediates FGF6's effects. Crosstalk with the PI3K/AKT pathway further enhances cellular survival and growth showing the broad involvement of FGF6 in musculoskeletal pathway networks.

Researchers link FGF6 to conditions such as muscular dystrophy and certain types of cancers. Its involvement in muscular dystrophies highlights its role in improper muscle repair and maintenance. In cancer FGF6 may contribute to tumor growth and progression due to its proliferative effects. Proteins like FGFR1 play a role in mediating FGF6’s influence in these diseases providing critical insights into potential therapeutic targets.