Recombinant human FGF6 protein (Animal Free) is a Human Fragment protein, in the 41 to 208 aa range, expressed in Escherichia coli, with >=95% purity, <= 1 EU/µg endotoxin level and suitable for SDS-PAGE, FuncS.
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Key facts
- Purity
- >=95% SDS-PAGE
- Endotoxin level
- <= 1 EU/µg
- Expression system
- Escherichia coli
- Tags
- Tag free
- Applications
- SDS-PAGE, FuncS
- Biologically active
- Yes
Amino acid sequence
M G T R A N N T L L D S R G W G T L L S R S R A G L A G E I A G V N W E S G Y L V G I K R Q R R L Y C N V G I G F H L Q V L P D G R I S G T H E E N P Y S L L E I S T V E R G V V S L F G V R S A L F V A M N S K G R L Y A T P S F Q E E C K F R E T L L P N N Y N A Y E S D L Y Q G T Y I A L S K Y G R V K R G S K V S P I M T V T H F L P R I
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application FuncS | Reactivity Reacts | Dilution info - | Notes - |
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Target data
Function
Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration.
Alternative names
HST2, HSTF2, FGF6, Fibroblast growth factor 6, FGF-6, Heparin secretory-transforming protein 2, Heparin-binding growth factor 6, HST-2, HSTF-2, HBGF-6
Recommended products
Recombinant human FGF6 protein (Animal Free) is a Human Fragment protein, in the 41 to 208 aa range, expressed in Escherichia coli, with >=95% purity, <= 1 EU/µg endotoxin level and suitable for SDS-PAGE, FuncS.
Key facts
- Purity
- >=95% SDS-PAGE
- Endotoxin level
- <= 1 EU/µg
- Expression system
- Escherichia coli
- Tags
- Tag free
- Applications
- SDS-PAGE, FuncS
- Biologically active
- Yes
- Biological activity
- Proliferation of NR6R-3T3 cells with 1 μg heparin: ≤1 ng/ml; ≥ 1.0 x 106 units/mg.
- Accession
- P10767-1
- Animal free
- Yes
- Carrier free
- Yes
- Species
- Human
- Reconstitution
- Reconstitute at 0.1 mg/mL in water
- Concentration
- Storage buffer
Constituents: 0.29% Sodium chloride, 0.16% Sodium phosphate
Sequence info
Amino acid sequence
- M G T R A N N T L L D S R G W G T L L S R S R A G L A G E I A G V N W E S G Y L V G I K R Q R R L Y C N V G I G F H L Q V L P D G R I S G T H E E N P Y S L L E I S T V E R G V V S L F G V R S A L F V A M N S K G R L Y A T P S F Q E E C K F R E T L L P N N Y N A Y E S D L Y Q G T Y I A L S K Y G R V K R G S K V S P I M T V T H F L P R I
- Accession
- P10767
- Protein length
- Fragment
- Predicted molecular weight
- 18.9 kDa
- Amino acids
- 41 to 208
- Nature
- Recombinant
Specifications
- Form
- Lyophilized
General info
- Function
Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration.
- Sequence similarities
Belongs to the heparin-binding growth factors family.
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
FGF6 also known as Fibroblast Growth Factor 6 is a protein that plays an important role in muscle development and repair. It has a molecular mass of approximately 23 kDa. Researchers find FGF6 to be expressed mainly in skeletal muscle tissue indicating its specific role in muscular activities. Apart from muscle tissues evidence also suggests its expression in certain brain areas contributing to its diverse functions.
- Biological function summary
FGF6 belongs to the fibroblast growth factor family which is essential for cell proliferation and differentiation. It significantly influences muscle regeneration and repair after injury. Though FGF6 acts independently it often interacts with FGF receptors on the cell surface to stimulate cellular responses. Its activity does not limit to isolated action but integrates well with complex cellular processes important for muscle tissue maintenance.
- Pathways
FGF6 plays a role in signaling cascades such as the MAPK/ERK pathway that regulates various cellular activities like proliferation and differentiation. This pathway involves important interactions with proteins like FGFR1 a receptor that mediates FGF6's effects. Crosstalk with the PI3K/AKT pathway further enhances cellular survival and growth showing the broad involvement of FGF6 in musculoskeletal pathway networks.
- Associated diseases and disorders
Researchers link FGF6 to conditions such as muscular dystrophy and certain types of cancers. Its involvement in muscular dystrophies highlights its role in improper muscle repair and maintenance. In cancer FGF6 may contribute to tumor growth and progression due to its proliferative effects. Proteins like FGFR1 play a role in mediating FGF6’s influence in these diseases providing critical insights into potential therapeutic targets.
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2 product images
SDS-PAGE - Recombinant human FGF6 protein (Animal Free) (ab256002)
SDS-PAGE analysis of ab256002 (1 μg) under non-reducing (Lane 1) and reducing (Lane 2) conditions.
4-20% Tris-Glycine gel. Coomassie Blue staining.
Functional Studies - Recombinant human FGF6 protein (Animal Free) (ab256002)
ab256002 induced proliferation of NR6R-3T3 cells with 1 μg heparin.
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