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AB182831

Recombinant Human FGFBP1 protein

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Recombinant Human FGFBP1 protein is a Human Full Length protein, in the 24 to 234 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

FGFBP, HBP17, FGFBP1, Fibroblast growth factor-binding protein 1, FGF-BP, FGF-BP1, FGF-binding protein 1, FGFBP-1, 17 kDa heparin-binding growth factor-binding protein, 17 kDa HBGF-binding protein, HBp17

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His-T7 tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q14512

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MASMTGGQQMGRGHHHHHHENLYFQGGEFKKKVKNGLHSKVVSEQKDTLGNTQIKQKSRPGNKGKFVTKDQANCRWAATEQEEGISLKVECTQLDHEFSCVFAGNPTSCLKLKDERVYWKQVARNLRSQKDICRYSKTAVKTRVCRKDFPESSLKLVSSTLFGNTKPRKEKTEMSPREHIKGKETTPSSLAVTQTMATKAPECVEDPDMANQRKTALEFCGETWSSLCTFFLSIVQDTSC","proteinLength":"Full Length","predictedMolecularWeight":"27 kDa","actualMolecularWeight":null,"aminoAcidEnd":234,"aminoAcidStart":24,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q14512","tags":[{"tag":"His-T7","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FGFBP1 also known as fibroblast growth factor binding protein 1 is an extracellular regulatory protein that mechanically binds fibroblast growth factors (FGFs). This protein has a molecular mass of approximately 30 kilodaltons. FGFBP1 is expressed in various tissues including the skin liver and kidney. It acts as a carrier enhancing the bioavailability of FGFs by releasing them from the extracellular matrix or cell surfaces facilitating their interaction with FGF receptors.
Biological function summary

FGFBP1 plays a significant role in modulating FGF signaling influencing processes such as angiogenesis wound healing and tissue repair. It acts in conjunction with other FGFs to form a complex that is essential for efficient signal transduction across cellular membranes. By interacting with FGFs FGFBP1 impacts cell proliferation and differentiation particularly in epithelial and endothelial cells.

Pathways

FGFBP1 is a critical component of the FGF signaling pathway and has a role in pathways related to cell growth and tissue development. It works alongside other proteins such as FGF1 and FGF2 to regulate developmental processes. The interaction of FGFBP1 in the signaling pathway ensures the proper function and maintenance of cellular activities aligning with processes like angiogenesis and morphogenesis.

FGFBP1 has connections to cancer and chronic inflammatory diseases such as psoriasis. In cancer FGFBP1's role in promoting FGF-mediated angiogenesis supports tumor growth and metastasis especially in collaboration with other FGFs like FGF2. In chronic inflammatory disorders dysregulation of FGFBP1 can lead to aberrant FGF signaling contributing to excessive tissue inflammation and impaired healing. This highlights its potential as a target for therapeutic intervention in these conditions.
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Specifications

Form

Liquid

Additional notes

ab182831 was refolded using unique “temperature shift inclusion body refolding” technology and chromatographically purified.

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General info

Function

Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth.

Sequence similarities

Belongs to the fibroblast growth factor-binding protein family.

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Product protocols

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Target data

Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth.
See full target information FGFBP1
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Primary Antibodies

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Secondary Antibodies

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Primary Antibodies

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Product promise

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