Recombinant human FGFBP1 protein (Active) is a Human Full Length protein, in the 24 to 234 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, FuncS, HPLC.
>95% SDS-PAGE
Escherichia coli
Tag free
SDS-PAGE, FuncS, HPLC
Yes
M K K K V K N G L H S K V V S E Q K D T L G N T Q I K Q K S R P G N K G K F V T K D Q A N C R W A A T E Q E E G I S L K V E C T Q L D H E F S C V F A G N P T S C L K L K D E R V Y W K Q V A R N L R S Q K D I C R Y S K T A V K T R V C R K D F P E S S L K L V S S T L F G N T K P R K E K T E M S P R E H I K G K E T T P S S L A V T Q T M A T K A P E C V E D P D M A N Q R K T A L E F C G E T W S S L C T F F L S I V Q D T S C
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application FuncS | Reactivity Reacts | Dilution info - | Notes - |
Application HPLC | Reactivity Reacts | Dilution info - | Notes - |
Select an associated product type
Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth.
Fibroblast growth factor-binding protein 1, FGF-BP, FGF-BP1, FGF-binding protein 1, FGFBP-1, 17 kDa heparin-binding growth factor-binding protein, 17 kDa HBGF-binding protein, HBp17, HBP17, FGFBP, FGFBP1
Recombinant human FGFBP1 protein (Active) is a Human Full Length protein, in the 24 to 234 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, FuncS, HPLC.
Fibroblast growth factor-binding protein 1, FGF-BP, FGF-BP1, FGF-binding protein 1, FGFBP-1, 17 kDa heparin-binding growth factor-binding protein, 17 kDa HBGF-binding protein, HBp17, HBP17, FGFBP, FGFBP1
>95% SDS-PAGE
Escherichia coli
Tag free
SDS-PAGE, FuncS, HPLC
Yes
Determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors. The expected ED50 for this effect is 1.5-3.0 μg/ml.
No
Human
Reconstitute in water to 0.1 - 1.0 mg/ml.
Constituents: 0.29% Sodium citrate
M K K K V K N G L H S K V V S E Q K D T L G N T Q I K Q K S R P G N K G K F V T K D Q A N C R W A A T E Q E E G I S L K V E C T Q L D H E F S C V F A G N P T S C L K L K D E R V Y W K Q V A R N L R S Q K D I C R Y S K T A V K T R V C R K D F P E S S L K L V S S T L F G N T K P R K E K T E M S P R E H I K G K E T T P S S L A V T Q T M A T K A P E C V E D P D M A N Q R K T A L E F C G E T W S S L C T F F L S I V Q D T S C
Full Length
24 kDa
24 to 234
Recombinant
Lyophilized
Greater than 95% by HPLC analyses.
Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth.
Belongs to the fibroblast growth factor-binding protein family.
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
This product is an active protein and may elicit a biological response in vivo, handle with caution.
This supplementary information is collated from multiple sources and compiled automatically.
FGFBP1 also known as fibroblast growth factor binding protein 1 is an extracellular regulatory protein that mechanically binds fibroblast growth factors (FGFs). This protein has a molecular mass of approximately 30 kilodaltons. FGFBP1 is expressed in various tissues including the skin liver and kidney. It acts as a carrier enhancing the bioavailability of FGFs by releasing them from the extracellular matrix or cell surfaces facilitating their interaction with FGF receptors.
FGFBP1 plays a significant role in modulating FGF signaling influencing processes such as angiogenesis wound healing and tissue repair. It acts in conjunction with other FGFs to form a complex that is essential for efficient signal transduction across cellular membranes. By interacting with FGFs FGFBP1 impacts cell proliferation and differentiation particularly in epithelial and endothelial cells.
FGFBP1 is a critical component of the FGF signaling pathway and has a role in pathways related to cell growth and tissue development. It works alongside other proteins such as FGF1 and FGF2 to regulate developmental processes. The interaction of FGFBP1 in the signaling pathway ensures the proper function and maintenance of cellular activities aligning with processes like angiogenesis and morphogenesis.
FGFBP1 has connections to cancer and chronic inflammatory diseases such as psoriasis. In cancer FGFBP1's role in promoting FGF-mediated angiogenesis supports tumor growth and metastasis especially in collaboration with other FGFs like FGF2. In chronic inflammatory disorders dysregulation of FGFBP1 can lead to aberrant FGF signaling contributing to excessive tissue inflammation and impaired healing. This highlights its potential as a target for therapeutic intervention in these conditions.
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