JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB126678

Recombinant Human FGFR1 Oncogene Partner protein (His tag N-Terminus)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human FGFR1 Oncogene Partner protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 379 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

FGFR1OP, FOP, CEP43, Centrosomal protein 43, FGFR1 oncogene partner

1 Images
SDS-PAGE - Recombinant Human FGFR1 Oncogene Partner protein (His tag N-Terminus) (AB126678)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human FGFR1 Oncogene Partner protein (His tag N-Terminus) (AB126678)

15% SDS-PAGE showing ab126678 (3 µg).

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

O95684

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMAATAAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQFFNLDFTLAVFQPETSTLQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPTTGEGALDLSDVHSPPKSPEGKTSAQTTPSKKANDEANQSDTSVSLSEPKSKSSLHLLSHETKIGSFLSNRTLDGKDKAGLCPDEDDMEGDSFFDDPIPKPEKTYGLRKEPRKQAGSLASLSDAPPLKSGLSSLAGAPSLKDSESKRGNTVLKDLKLISDKIGSLGLGTGEDDDYVDDFNSTSHRSEKSEISIGEEIEEDLSVEIDDINTSDKLDDLTQDLTVSQLSDVADYLEDVA","proteinLength":"Full Length","predictedMolecularWeight":"43.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":379,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O95684","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The FGFR1 Oncogene Partner also known as FOP is a protein predominantly involved in cellular processes related to the fibroblast growth factor receptor 1 (FGFR1). It exhibits a molecular weight of approximately 60 kDa. FGFR1 Oncogene Partner is expressed in various tissues including bone marrow and other hematopoietic tissues. It contains conserved regions essential for its function as a molecular adaptor or scaffold playing a significant role in protein-protein interactions.
Biological function summary

FOP functions as an adaptor protein facilitating the assembly and organization of the centrosome a critical cellular structure required for proper cell division. FOP plays a role in the formation of a multi-protein complex comprising FGFR1 contributing to cellular signaling regulation. This complex assists in ensuring appropriate cellular responses to growth factor stimuli. FOP displays interactions with other cytoskeletal and signaling proteins highlighting its importance in modulating cellular architecture and division.

Pathways

Various proteins interact with FGFR1 Oncogene Partner as part of the FGFR signaling and centrosome architecture processes. The primary pathway involving FOP is the FGFR signaling pathway where it facilitates the FGFR1's recruitment to the centrosome. This interaction allows for efficient signal transduction necessary for cell proliferation and differentiation. FOP also associates with proteins like ALMS1 affecting cellular organization and stability highlighting its participation in centrosome-related signaling cascades.

Alterations in FOP expression or function have links to various conditions notably cancer and craniosynostosis. In certain cancers FOP involvement with FGFR1 leads to oncogenic fusion proteins enhancing aberrant signaling and contributing to tumor growth and progression. Furthermore craniosynostosis links to disruptions in centrosome functionality where mutated FOP can affect skeletal development. The protein's interactions with FGFR1 and other centrosomal partners position it significantly in the etiology of these diseases.
style
left-column

Specifications

Form

Liquid

Additional notes

ab126678 is purified by using conventional chromatography techniques.

style
left-column

General info

Function

Required for anchoring microtubules to the centrosomes (PubMed : 16314388, PubMed : 28659385). Required for ciliation (PubMed : 28625565, PubMed : 28659385).

Sequence similarities

Belongs to the CEP43 family.

Subcellular localisation

Cytoskeleton

style
left-column

Product protocols

style
left-column

Target data

Required for anchoring microtubules to the centrosomes (PubMed : 16314388, PubMed : 28659385). Required for ciliation (PubMed : 28625565, PubMed : 28659385).
See full target information CEP43
style
left-column
style
left-column
style
right-column

Complementary Products

Proteins & Peptides

AB290111

Recombinant Human FGFR1 Protein (Active)

Premium Bioactive

Functional Studies - Recombinant Human FGFR1 Protein (Active) (AB290111)

  • 0
  • 0
Proteins & Peptides

AB288799

Recombinant Human VCAM1 protein (Active)

Premium Bioactive

Biological Activity - Recombinant Human VCAM1 protein (Active) (AB288799)

  • 0
  • 0
Proteins & Peptides

AB49001

Recombinant Human VAMP2 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human VAMP2 protein (AB49001)

  • 0
  • 0
Proteins & Peptides

AB316467

Recombinant Human TFPI Protein Standard (His tag)

Sandwich ELISA - Recombinant Human TFPI Protein Standard (His tag) (AB316467)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com