Recombinant Human FGL2/Prothrombinase protein is a Human Full Length protein, in the 1 to 439 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Wheat germ
GST tag N-Terminus
ELISA, WB
No
M K L A N W Y W L S S A V L A T Y G F L V V A N N E T E E I K D E R A K D V C P V R L E S R G K C E E A G E C P Y Q V S L P P L T I Q L P K Q F S R I E E V F K E V Q N L K E I V N S L K K S C Q D C K L Q A D D N G D P G R N G L L L P S T G A P G E V G D N R V R E L E S E V N K L S S E L K N A K E E I N V L H G R L E K L N L V N M N N I E N Y V D S K V A N L T F V V N S L D G K C S K C P S Q E Q I Q S R P V Q H L I Y K D C S D Y Y A I G K R S S E T Y R V T P D P K N S S F E V Y C D M E T M G G G W T V L Q A R L D G S T N F T R T W Q D Y K A G F G N L R R E F W L G N D K I H L L T K S K E M I L R I D L E D F N G V E L Y A L Y D Q F Y V A N E F L K Y R L H V G N Y N G T A G D A L R F N K H Y N H D L K F F T T P D K D N D R Y P S G N C G L Y Y S S G W W F D A C L S A N L N G K Y Y H Q K Y R G V R N G I F W G T W P G V S E A H P G G Y K S S F K E A K M M I R P K H F K P
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
May play a role in physiologic lymphocyte functions at mucosal sites.
Fibroleukin, Fibrinogen-like protein 2, pT49, FGL2
Recombinant Human FGL2/Prothrombinase protein is a Human Full Length protein, in the 1 to 439 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Wheat germ
GST tag N-Terminus
ELISA, WB
No
No
Human
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
M K L A N W Y W L S S A V L A T Y G F L V V A N N E T E E I K D E R A K D V C P V R L E S R G K C E E A G E C P Y Q V S L P P L T I Q L P K Q F S R I E E V F K E V Q N L K E I V N S L K K S C Q D C K L Q A D D N G D P G R N G L L L P S T G A P G E V G D N R V R E L E S E V N K L S S E L K N A K E E I N V L H G R L E K L N L V N M N N I E N Y V D S K V A N L T F V V N S L D G K C S K C P S Q E Q I Q S R P V Q H L I Y K D C S D Y Y A I G K R S S E T Y R V T P D P K N S S F E V Y C D M E T M G G G W T V L Q A R L D G S T N F T R T W Q D Y K A G F G N L R R E F W L G N D K I H L L T K S K E M I L R I D L E D F N G V E L Y A L Y D Q F Y V A N E F L K Y R L H V G N Y N G T A G D A L R F N K H Y N H D L K F F T T P D K D N D R Y P S G N C G L Y Y S S G W W F D A C L S A N L N G K Y Y H Q K Y R G V R N G I F W G T W P G V S E A H P G G Y K S S F K E A K M M I R P K H F K P
Full Length
1 to 439
Recombinant
GST tag N-Terminus
Liquid
May play a role in physiologic lymphocyte functions at mucosal sites.
Dry Ice
-80°C
-80°C
Upon delivery aliquot
Avoid freeze / thaw cycle
This product was previously labelled as FGL2.
This supplementary information is collated from multiple sources and compiled automatically.
FGL2 also known as Fibroleukin or Prothrombinase is a protein involved in various physiological and pathological processes. Its molecular mass is approximately 70 kDa. This protein is widely expressed in different tissues including the liver and the spleen as well as in immune cells such as T cells and macrophages. It serves as an important signaling molecule and mediator in various biological pathways due to its capacity to interact with other proteins and molecular complexes.
FGL2 acts in immune response modulation and blood coagulation. It can exist as a homodimer or form part of a larger protein complex. One of its roles involves cleaving prothrombin to generate thrombin contributing to the coagulation cascade. Moreover FGL2 has immunosuppressive properties affecting T cell proliferation and cytokine release. Its dual function in coagulation and immune regulation points to its importance in maintaining homeostasis and orchestrating immune responses.
FGL2 serves key roles in both the coagulation and immune pathways. In the coagulation pathway FGL2 aids in the conversion of prothrombin to thrombin bridging innate immunity with coagulation processes. This action places it in close functional relationship with proteins in the coagulation pathway such as thrombin and fibrin. Moreover its involvement in immune pathways aligns it with cytokines and interferons modulating the immune response and maintaining immune system balance.
FGL2 plays significant roles in conditions such as viral hepatitis and certain autoimmune disorders. In viral hepatitis FGL2's upregulation contributes to liver fibrosis and inflammation often in conjunction with another protein CD147. In autoimmune disorders the dysregulation of FGL2 can lead to excessive inflammatory responses impacting proteins like the interferon-gamma. Understanding FGL2's involvement in these diseases can inform therapeutic strategies targeting both coagulation and immune dysregulation.
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ab161182 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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