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Recombinant Human FGL2/Prothrombinase protein is a Human Full Length protein, in the 1 to 439 aa range, expressed in Wheat germ and suitable for ELISA, WB.

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Images

SDS-PAGE - Recombinant Human FGL2/Prothrombinase protein (AB161182), expandable thumbnail

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

Biologically active

No

Amino acid sequence

M K L A N W Y W L S S A V L A T Y G F L V V A N N E T E E I K D E R A K D V C P V R L E S R G K C E E A G E C P Y Q V S L P P L T I Q L P K Q F S R I E E V F K E V Q N L K E I V N S L K K S C Q D C K L Q A D D N G D P G R N G L L L P S T G A P G E V G D N R V R E L E S E V N K L S S E L K N A K E E I N V L H G R L E K L N L V N M N N I E N Y V D S K V A N L T F V V N S L D G K C S K C P S Q E Q I Q S R P V Q H L I Y K D C S D Y Y A I G K R S S E T Y R V T P D P K N S S F E V Y C D M E T M G G G W T V L Q A R L D G S T N F T R T W Q D Y K A G F G N L R R E F W L G N D K I H L L T K S K E M I L R I D L E D F N G V E L Y A L Y D Q F Y V A N E F L K Y R L H V G N Y N G T A G D A L R F N K H Y N H D L K F F T T P D K D N D R Y P S G N C G L Y Y S S G W W F D A C L S A N L N G K Y Y H Q K Y R G V R N G I F W G T W P G V S E A H P G G Y K S S F K E A K M M I R P K H F K P

Reactivity data

Application

ELISA

Reactivity

Reacts

Dilution info

-

Notes

-

Application

WB

Reactivity

Reacts

Dilution info

-

Notes

-

Target data

Function

May play a role in physiologic lymphocyte functions at mucosal sites.

Alternative names

Recommended products

Recombinant Human FGL2/Prothrombinase protein is a Human Full Length protein, in the 1 to 439 aa range, expressed in Wheat germ and suitable for ELISA, WB.

Key facts

Expression system

Wheat germ

Applications

ELISA, WB

Accession
Q14314-1
Animal free

No

Species

Human

Concentration
Loading...
Storage buffer

pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione

Sequence info

Amino acid sequence

M K L A N W Y W L S S A V L A T Y G F L V V A N N E T E E I K D E R A K D V C P V R L E S R G K C E E A G E C P Y Q V S L P P L T I Q L P K Q F S R I E E V F K E V Q N L K E I V N S L K K S C Q D C K L Q A D D N G D P G R N G L L L P S T G A P G E V G D N R V R E L E S E V N K L S S E L K N A K E E I N V L H G R L E K L N L V N M N N I E N Y V D S K V A N L T F V V N S L D G K C S K C P S Q E Q I Q S R P V Q H L I Y K D C S D Y Y A I G K R S S E T Y R V T P D P K N S S F E V Y C D M E T M G G G W T V L Q A R L D G S T N F T R T W Q D Y K A G F G N L R R E F W L G N D K I H L L T K S K E M I L R I D L E D F N G V E L Y A L Y D Q F Y V A N E F L K Y R L H V G N Y N G T A G D A L R F N K H Y N H D L K F F T T P D K D N D R Y P S G N C G L Y Y S S G W W F D A C L S A N L N G K Y Y H Q K Y R G V R N G I F W G T W P G V S E A H P G G Y K S S F K E A K M M I R P K H F K P

Accession

Q14314

Protein length

Full Length

Amino acids

1 to 439

Nature

Recombinant

Tags

GST tag N-Terminus

Specifications

Form

Liquid

General info

Function

May play a role in physiologic lymphocyte functions at mucosal sites.

Storage

Shipped at conditions

Dry Ice

Appropriate short-term storage conditions

-80°C

Appropriate long-term storage conditions

-80°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

This product was previously labelled as FGL2.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

FGL2 also known as Fibroleukin or Prothrombinase is a protein involved in various physiological and pathological processes. Its molecular mass is approximately 70 kDa. This protein is widely expressed in different tissues including the liver and the spleen as well as in immune cells such as T cells and macrophages. It serves as an important signaling molecule and mediator in various biological pathways due to its capacity to interact with other proteins and molecular complexes.

Biological function summary

FGL2 acts in immune response modulation and blood coagulation. It can exist as a homodimer or form part of a larger protein complex. One of its roles involves cleaving prothrombin to generate thrombin contributing to the coagulation cascade. Moreover FGL2 has immunosuppressive properties affecting T cell proliferation and cytokine release. Its dual function in coagulation and immune regulation points to its importance in maintaining homeostasis and orchestrating immune responses.

Pathways

FGL2 serves key roles in both the coagulation and immune pathways. In the coagulation pathway FGL2 aids in the conversion of prothrombin to thrombin bridging innate immunity with coagulation processes. This action places it in close functional relationship with proteins in the coagulation pathway such as thrombin and fibrin. Moreover its involvement in immune pathways aligns it with cytokines and interferons modulating the immune response and maintaining immune system balance.

Associated diseases and disorders

FGL2 plays significant roles in conditions such as viral hepatitis and certain autoimmune disorders. In viral hepatitis FGL2's upregulation contributes to liver fibrosis and inflammation often in conjunction with another protein CD147. In autoimmune disorders the dysregulation of FGL2 can lead to excessive inflammatory responses impacting proteins like the interferon-gamma. Understanding FGL2's involvement in these diseases can inform therapeutic strategies targeting both coagulation and immune dysregulation.

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1 product image

  • SDS-PAGE - Recombinant Human FGL2/Prothrombinase protein (ab161182), expandable thumbnail

    SDS-PAGE - Recombinant Human FGL2/Prothrombinase protein (ab161182)

    ab161182 on a 12.5% SDS-PAGE stained with Coomassie Blue.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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