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Recombinant Human FIBP protein is a Human Full Length protein, in the 1 to 364 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.

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Images

SDS-PAGE - Recombinant Human FIBP protein (AB156710), expandable thumbnail

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, MS

Biologically active

No

Amino acid sequence

M G S S H H H H H H S S G L V P R G S H M G S M T S E L D I F V G N T T L I D E D V Y R L W L D G Y S V T D A V A L R V R S G I L E Q T G A T A A V L Q S D T M D H Y R T F H M L E R L L H A P P K L L H Q L I F Q I P P S R Q A L L I E R Y Y A F D E A F V R E V L G K K L S K G T K K D L D D I S T K T G I T L K S C R R Q F D N F K R V F K V V E E M R G S L V D N I Q Q H F L L S D R L A R D Y A A I V F F A N N R F E T G K K K L Q Y L S F G D F A F C A E L M I Q N W T L G A V G E A P T D P D S Q M D D M D M D L D K E F L Q D L K E L K V L V A D K D L L D L H K S L V C T A L R G K L G V F S E M E A N F K N L S R G L V N V A A K L T H N K D V R D L F V D L V E K F V E P C R S D H W P L S D V R F F L N Q Y S A S V H S L D G F R H Q A L W D R Y M G T L R G C L L R L Y H D

Reactivity data

Application

SDS-PAGE

Reactivity

Reacts

Dilution info

-

Notes

-

Application

MS

Reactivity

Reacts

Dilution info

-

Notes

-

Target data

Function

May be involved in mitogenic function of FGF1. May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo (By similarity).

Alternative names

Recommended products

Recombinant Human FIBP protein is a Human Full Length protein, in the 1 to 364 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Applications

SDS-PAGE, MS

Accession
O43427-1
Animal free

No

Species

Human

Concentration
Loading...
Storage buffer

pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 0.32% Tris HCl

Sequence info

Amino acid sequence

M G S S H H H H H H S S G L V P R G S H M G S M T S E L D I F V G N T T L I D E D V Y R L W L D G Y S V T D A V A L R V R S G I L E Q T G A T A A V L Q S D T M D H Y R T F H M L E R L L H A P P K L L H Q L I F Q I P P S R Q A L L I E R Y Y A F D E A F V R E V L G K K L S K G T K K D L D D I S T K T G I T L K S C R R Q F D N F K R V F K V V E E M R G S L V D N I Q Q H F L L S D R L A R D Y A A I V F F A N N R F E T G K K K L Q Y L S F G D F A F C A E L M I Q N W T L G A V G E A P T D P D S Q M D D M D M D L D K E F L Q D L K E L K V L V A D K D L L D L H K S L V C T A L R G K L G V F S E M E A N F K N L S R G L V N V A A K L T H N K D V R D L F V D L V E K F V E P C R S D H W P L S D V R F F L N Q Y S A S V H S L D G F R H Q A L W D R Y M G T L R G C L L R L Y H D

Accession

O43427

Protein length

Full Length

Predicted molecular weight

44.3 kDa

Amino acids

1 to 364

Nature

Recombinant

Tags

His tag N-Terminus

Specifications

Form

Liquid

Additional notes

ab156710 is purified using conventional chromatography techniques.

General info

Function

May be involved in mitogenic function of FGF1. May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo (By similarity).

Subcellular localisation

Nucleus

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

FIBP also known as FGF-binding protein is a protein with a molecular mass of approximately 42 kDa. This protein interacts mechanically with fibroblast growth factors (FGFs) and affects their activity. FIBP is expressed in various tissues including brain heart and kidney. Researchers have studied how it binds to acidic and basic FGFs which play roles in multiple cellular processes.

Biological function summary

FIBP influences the modulation of cell growth and differentiation. It does not form a known complex but interacts with FGFs impacting their bioavailability and function. These roles make it integral to cellular processes where FGF signaling is important such as tissue repair and embryonic development. Understanding its interaction with FGFs helps in studying various physiological and pathological states.

Pathways

FIBP plays a role in the fibroblast growth factor signaling pathway. This pathway involves FGFRs (fibroblast growth factor receptors) and proteins such as ERK1/2 which are essential for signal transduction. FIBP affects FGF localization and modulation influencing how signals propagate within the pathway. This regulation holds importance in cellular proliferation and survival key functions within the growth factor signaling networks.

Associated diseases and disorders

FIBP has associations with cancer and developmental disorders. Abnormal FGF signaling mediated by FIBP can lead to tumorigenesis and aberrant development. FGF interactions connect FIBP with FGFR mutations or dysregulations often seen in various cancers. Understanding the relationship between FIBP and disease pathways advances research on therapeutic targets and diagnostic markers.

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1 product image

  • SDS-PAGE - Recombinant Human FIBP protein (ab156710), expandable thumbnail

    SDS-PAGE - Recombinant Human FIBP protein (ab156710)

    15% SDS-PAGE analysis of ab156710 (3μg).

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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