Recombinant Human FIBP protein is a Human Full Length protein, in the 1 to 364 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S M T S E L D I F V G N T T L I D E D V Y R L W L D G Y S V T D A V A L R V R S G I L E Q T G A T A A V L Q S D T M D H Y R T F H M L E R L L H A P P K L L H Q L I F Q I P P S R Q A L L I E R Y Y A F D E A F V R E V L G K K L S K G T K K D L D D I S T K T G I T L K S C R R Q F D N F K R V F K V V E E M R G S L V D N I Q Q H F L L S D R L A R D Y A A I V F F A N N R F E T G K K K L Q Y L S F G D F A F C A E L M I Q N W T L G A V G E A P T D P D S Q M D D M D M D L D K E F L Q D L K E L K V L V A D K D L L D L H K S L V C T A L R G K L G V F S E M E A N F K N L S R G L V N V A A K L T H N K D V R D L F V D L V E K F V E P C R S D H W P L S D V R F F L N Q Y S A S V H S L D G F R H Q A L W D R Y M G T L R G C L L R L Y H D
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
May be involved in mitogenic function of FGF1. May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo (By similarity).
Alternative names
Acidic fibroblast growth factor intracellular-binding protein, aFGF intracellular-binding protein, FGF-1 intracellular-binding protein, FIBP
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Recombinant Human FIBP protein is a Human Full Length protein, in the 1 to 364 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- O43427-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 0.32% Tris HCl
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S M T S E L D I F V G N T T L I D E D V Y R L W L D G Y S V T D A V A L R V R S G I L E Q T G A T A A V L Q S D T M D H Y R T F H M L E R L L H A P P K L L H Q L I F Q I P P S R Q A L L I E R Y Y A F D E A F V R E V L G K K L S K G T K K D L D D I S T K T G I T L K S C R R Q F D N F K R V F K V V E E M R G S L V D N I Q Q H F L L S D R L A R D Y A A I V F F A N N R F E T G K K K L Q Y L S F G D F A F C A E L M I Q N W T L G A V G E A P T D P D S Q M D D M D M D L D K E F L Q D L K E L K V L V A D K D L L D L H K S L V C T A L R G K L G V F S E M E A N F K N L S R G L V N V A A K L T H N K D V R D L F V D L V E K F V E P C R S D H W P L S D V R F F L N Q Y S A S V H S L D G F R H Q A L W D R Y M G T L R G C L L R L Y H D
- Accession
- O43427
- Protein length
- Full Length
- Predicted molecular weight
- 44.3 kDa
- Amino acids
- 1 to 364
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab156710 is purified using conventional chromatography techniques.
General info
- Function
May be involved in mitogenic function of FGF1. May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo (By similarity).
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
FIBP also known as FGF-binding protein is a protein with a molecular mass of approximately 42 kDa. This protein interacts mechanically with fibroblast growth factors (FGFs) and affects their activity. FIBP is expressed in various tissues including brain heart and kidney. Researchers have studied how it binds to acidic and basic FGFs which play roles in multiple cellular processes.
- Biological function summary
FIBP influences the modulation of cell growth and differentiation. It does not form a known complex but interacts with FGFs impacting their bioavailability and function. These roles make it integral to cellular processes where FGF signaling is important such as tissue repair and embryonic development. Understanding its interaction with FGFs helps in studying various physiological and pathological states.
- Pathways
FIBP plays a role in the fibroblast growth factor signaling pathway. This pathway involves FGFRs (fibroblast growth factor receptors) and proteins such as ERK1/2 which are essential for signal transduction. FIBP affects FGF localization and modulation influencing how signals propagate within the pathway. This regulation holds importance in cellular proliferation and survival key functions within the growth factor signaling networks.
- Associated diseases and disorders
FIBP has associations with cancer and developmental disorders. Abnormal FGF signaling mediated by FIBP can lead to tumorigenesis and aberrant development. FGF interactions connect FIBP with FGFR mutations or dysregulations often seen in various cancers. Understanding the relationship between FIBP and disease pathways advances research on therapeutic targets and diagnostic markers.
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SDS-PAGE - Recombinant Human FIBP protein (ab156710)
15% SDS-PAGE analysis of ab156710 (3μg).
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