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AB156710

Recombinant Human FIBP protein (His tag N-Terminus)

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Recombinant Human FIBP protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 364 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

Acidic fibroblast growth factor intracellular-binding protein, aFGF intracellular-binding protein, FGF-1 intracellular-binding protein, FIBP

1 Images
SDS-PAGE - Recombinant Human FIBP protein (His tag N-Terminus) (AB156710)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human FIBP protein (His tag N-Terminus) (AB156710)

15% SDS-PAGE analysis of ab156710 (3μg).

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

O43427

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMTSELDIFVGNTTLIDEDVYRLWLDGYSVTDAVALRVRSGILEQTGATAAVLQSDTMDHYRTFHMLERLLHAPPKLLHQLIFQIPPSRQALLIERYYAFDEAFVREVLGKKLSKGTKKDLDDISTKTGITLKSCRRQFDNFKRVFKVVEEMRGSLVDNIQQHFLLSDRLARDYAAIVFFANNRFETGKKKLQYLSFGDFAFCAELMIQNWTLGAVGEAPTDPDSQMDDMDMDLDKEFLQDLKELKVLVADKDLLDLHKSLVCTALRGKLGVFSEMEANFKNLSRGLVNVAAKLTHNKDVRDLFVDLVEKFVEPCRSDHWPLSDVRFFLNQYSASVHSLDGFRHQALWDRYMGTLRGCLLRLYHD","proteinLength":"Full Length","predictedMolecularWeight":"44.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":364,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O43427","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FIBP also known as FGF-binding protein is a protein with a molecular mass of approximately 42 kDa. This protein interacts mechanically with fibroblast growth factors (FGFs) and affects their activity. FIBP is expressed in various tissues including brain heart and kidney. Researchers have studied how it binds to acidic and basic FGFs which play roles in multiple cellular processes.
Biological function summary

FIBP influences the modulation of cell growth and differentiation. It does not form a known complex but interacts with FGFs impacting their bioavailability and function. These roles make it integral to cellular processes where FGF signaling is important such as tissue repair and embryonic development. Understanding its interaction with FGFs helps in studying various physiological and pathological states.

Pathways

FIBP plays a role in the fibroblast growth factor signaling pathway. This pathway involves FGFRs (fibroblast growth factor receptors) and proteins such as ERK1/2 which are essential for signal transduction. FIBP affects FGF localization and modulation influencing how signals propagate within the pathway. This regulation holds importance in cellular proliferation and survival key functions within the growth factor signaling networks.

FIBP has associations with cancer and developmental disorders. Abnormal FGF signaling mediated by FIBP can lead to tumorigenesis and aberrant development. FGF interactions connect FIBP with FGFR mutations or dysregulations often seen in various cancers. Understanding the relationship between FIBP and disease pathways advances research on therapeutic targets and diagnostic markers.
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Specifications

Form

Liquid

Additional notes

ab156710 is purified using conventional chromatography techniques.

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General info

Function

May be involved in mitogenic function of FGF1. May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo (By similarity).

Subcellular localisation

Nucleus

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Product protocols

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Target data

May be involved in mitogenic function of FGF1. May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo (By similarity).
See full target information FIBP
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Complementary Products

Primary Antibodies

AB194793

Anti-FIBP antibody

Western blot - Anti-FIBP antibody (AB194793)

  • 0
  • 0
Cell Lines & Lysates

AB265716

Human FIBP knockout HeLa cell line

Sanger Sequencing - Human FIBP knockout HeLa cell line (AB265716)

  • 0
  • 0
Cell Lines & Lysates

AB263200

Human FIBP knockout HeLa cell lysate

Sanger Sequencing - Human FIBP knockout HeLa cell lysate (AB263200)

  • 0
  • 0

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