Recombinant Human FIBP protein is a Human Full Length protein, in the 1 to 364 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.
>95% SDS-PAGE
Escherichia coli
His tag N-Terminus
SDS-PAGE, MS
No
M G S S H H H H H H S S G L V P R G S H M G S M T S E L D I F V G N T T L I D E D V Y R L W L D G Y S V T D A V A L R V R S G I L E Q T G A T A A V L Q S D T M D H Y R T F H M L E R L L H A P P K L L H Q L I F Q I P P S R Q A L L I E R Y Y A F D E A F V R E V L G K K L S K G T K K D L D D I S T K T G I T L K S C R R Q F D N F K R V F K V V E E M R G S L V D N I Q Q H F L L S D R L A R D Y A A I V F F A N N R F E T G K K K L Q Y L S F G D F A F C A E L M I Q N W T L G A V G E A P T D P D S Q M D D M D M D L D K E F L Q D L K E L K V L V A D K D L L D L H K S L V C T A L R G K L G V F S E M E A N F K N L S R G L V N V A A K L T H N K D V R D L F V D L V E K F V E P C R S D H W P L S D V R F F L N Q Y S A S V H S L D G F R H Q A L W D R Y M G T L R G C L L R L Y H D
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
May be involved in mitogenic function of FGF1. May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo (By similarity).
Acidic fibroblast growth factor intracellular-binding protein, aFGF intracellular-binding protein, FGF-1 intracellular-binding protein, FIBP
Recombinant Human FIBP protein is a Human Full Length protein, in the 1 to 364 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.
>95% SDS-PAGE
Escherichia coli
His tag N-Terminus
SDS-PAGE, MS
No
No
Human
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 0.32% Tris HCl
M G S S H H H H H H S S G L V P R G S H M G S M T S E L D I F V G N T T L I D E D V Y R L W L D G Y S V T D A V A L R V R S G I L E Q T G A T A A V L Q S D T M D H Y R T F H M L E R L L H A P P K L L H Q L I F Q I P P S R Q A L L I E R Y Y A F D E A F V R E V L G K K L S K G T K K D L D D I S T K T G I T L K S C R R Q F D N F K R V F K V V E E M R G S L V D N I Q Q H F L L S D R L A R D Y A A I V F F A N N R F E T G K K K L Q Y L S F G D F A F C A E L M I Q N W T L G A V G E A P T D P D S Q M D D M D M D L D K E F L Q D L K E L K V L V A D K D L L D L H K S L V C T A L R G K L G V F S E M E A N F K N L S R G L V N V A A K L T H N K D V R D L F V D L V E K F V E P C R S D H W P L S D V R F F L N Q Y S A S V H S L D G F R H Q A L W D R Y M G T L R G C L L R L Y H D
Full Length
44.3 kDa
1 to 364
Recombinant
His tag N-Terminus
Liquid
ab156710 is purified using conventional chromatography techniques.
May be involved in mitogenic function of FGF1. May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo (By similarity).
Nucleus
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
This supplementary information is collated from multiple sources and compiled automatically.
FIBP also known as FGF-binding protein is a protein with a molecular mass of approximately 42 kDa. This protein interacts mechanically with fibroblast growth factors (FGFs) and affects their activity. FIBP is expressed in various tissues including brain heart and kidney. Researchers have studied how it binds to acidic and basic FGFs which play roles in multiple cellular processes.
FIBP influences the modulation of cell growth and differentiation. It does not form a known complex but interacts with FGFs impacting their bioavailability and function. These roles make it integral to cellular processes where FGF signaling is important such as tissue repair and embryonic development. Understanding its interaction with FGFs helps in studying various physiological and pathological states.
FIBP plays a role in the fibroblast growth factor signaling pathway. This pathway involves FGFRs (fibroblast growth factor receptors) and proteins such as ERK1/2 which are essential for signal transduction. FIBP affects FGF localization and modulation influencing how signals propagate within the pathway. This regulation holds importance in cellular proliferation and survival key functions within the growth factor signaling networks.
FIBP has associations with cancer and developmental disorders. Abnormal FGF signaling mediated by FIBP can lead to tumorigenesis and aberrant development. FGF interactions connect FIBP with FGFR mutations or dysregulations often seen in various cancers. Understanding the relationship between FIBP and disease pathways advances research on therapeutic targets and diagnostic markers.
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15% SDS-PAGE analysis of ab156710 (3μg).
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