Recombinant Human FIP protein is a Human Full Length protein, in the 1 to 346 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Wheat germ
Tag free
SDS-PAGE, ELISA, WB
No
M D M L D P G L D P A A S A T A A A A A S H D K G P E A E E G V E L Q E G G D G P G A E E Q T A V A I T S V Q Q A A F G D H N I Q Y Q F R T E T N G G Q V T Y R V V Q V T D G Q L D G Q G D T A G A V S V V S T A A F A G G Q Q A V T Q V G V D G A A Q R P G P A A A S V P P G P A A P F P L A V I Q N P F S N G G S P A A E A V S G E A R F A Y F P A S S V G D T T A V S V Q T T D Q S L Q A G G Q F Y V M M T P Q D V L Q T G T Q R T I A P R T H P Y S P K I D G T R T P R D E R R R A Q H N E V E R R R R D K I N N W I V Q L S K I I P D C N A D N S K T G A S K G G I L S K A C D Y I R E L R Q T N Q R M Q E T F K E A E R L Q M D N E L L R Q Q I E E L K N E N A L L R A Q L Q Q H N L E M V G E G T R Q
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.
BHLHB12, USF2, BHLHB12, Upstream stimulatory factor 2, Class B basic helix-loop-helix protein 12, FOS-interacting protein, Major late transcription factor 2, Upstream transcription factor 2, bHLHb12, FIP
Recombinant Human FIP protein is a Human Full Length protein, in the 1 to 346 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Wheat germ
Tag free
SDS-PAGE, ELISA, WB
No
No
Human
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
M D M L D P G L D P A A S A T A A A A A S H D K G P E A E E G V E L Q E G G D G P G A E E Q T A V A I T S V Q Q A A F G D H N I Q Y Q F R T E T N G G Q V T Y R V V Q V T D G Q L D G Q G D T A G A V S V V S T A A F A G G Q Q A V T Q V G V D G A A Q R P G P A A A S V P P G P A A P F P L A V I Q N P F S N G G S P A A E A V S G E A R F A Y F P A S S V G D T T A V S V Q T T D Q S L Q A G G Q F Y V M M T P Q D V L Q T G T Q R T I A P R T H P Y S P K I D G T R T P R D E R R R A Q H N E V E R R R R D K I N N W I V Q L S K I I P D C N A D N S K T G A S K G G I L S K A C D Y I R E L R Q T N Q R M Q E T F K E A E R L Q M D N E L L R Q Q I E E L K N E N A L L R A Q L Q Q H N L E M V G E G T R Q
Full Length
63.4 kDa
1 to 346
Recombinant
Liquid
Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.
Nucleus
Dry Ice
-80°C
-80°C
Upon delivery aliquot
Avoid freeze / thaw cycle
Protein previously labeled as USF2.
This supplementary information is collated from multiple sources and compiled automatically.
FIP also known as Family Interacting Protein or Optineurin is a multifunctional protein with a mass of approximately 66 kDa. It is expressed in various tissues with the highest levels in the heart brain and skeletal muscles. FIP functions mechanically as a scaffold protein interacting with a variety of cellular partners to regulate numerous processes. It contains multiple domains that allow it to bind to other proteins and influence cellular signaling pathways.
FIP impacts cell signaling vesicle trafficking and inflammation. It often participates as a part of larger protein complexes aiding in the fine-tuning of cellular responses. FIP acts as an important mediator in autophagy assisting in the degradation of damaged cellular components. The protein also modulates the inflammatory response by interacting with signaling molecules impacting pathways like NF-kB signaling and mitigating excessive inflammation.
FIP influences cellular homeostasis and immune responses. It plays a significant role in the NF-kB signaling pathway which regulates immune responses and cell survival. FIP forms interactions with proteins such as RIPK1 and ubiquitin chains affecting downstream signaling events. Additionally it participates in the autophagy pathway collaborating with proteins like LC3 to mediate the clearance of cellular debris which is critical for maintaining cellular health.
Aberrations in FIP function have been associated with glaucoma and amyotrophic lateral sclerosis (ALS). In glaucoma mutations in FIP are connected to altered autophagic processes impacting optic nerve health. The protein also interacts with TBK1 another factor linked to variations in immune and inflammatory responses contributing to the disease. Furthermore in ALS dysregulation in FIP’s regulatory role in autophagy and inflammation might accelerate neuronal degeneration highlighting its potential as a target for therapeutic intervention.
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12.5% SDS-PAGE showing ab152790 stained with Coomassie Blue.
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