Recombinant human FKBP2 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FKBP2 also known as FK506-binding protein 2 is a member of the immunophilin protein family and weighs approximately 15 kDa. Mechanically FKBP2 acts as a peptidyl-prolyl cis-trans isomerase facilitating the proper folding of proteins by catalyzing the interconversion between isomeric forms of proline in polypeptide chains. It is expressed mainly in the endoplasmic reticulum demonstrating strong involvement in cellular protein folding mechanisms. FKBP2 binds FK506 a macrolide with immunosuppressive properties which has identified its importance in various cell functions.

Biological function summary

FKBP2 plays significant roles in protein folding and trafficking within cells. It regulates calcium homeostasis by interacting with the calcium channels of the endoplasmic reticulum. FKBP2 often associates with complex components involved in signal transduction and cellular stress response emphasizing its roles in maintaining cellular equilibrium and reacting to external protein demands. This protein acts in coordination with other immunophilins providing a multifaceted approach to the management of protein conformation and cellular signaling.

Pathways

FKBP2 operates significantly within the protein folding and stress response pathways. It is closely related to the calcineurin signaling pathway primarily due to its interaction with immunosuppressant FK506 and its effect on calcineurin activity. In addition FKBP2 works alongside proteins like FKBP51 and HSP90 to ensure the proper functional configuration of molecular chaperones facilitating cellular adaptation under stress conditions and during protein synthesis.

FKBP2 has connections to neurodegenerative disorders and cardiovascular diseases revealing its impact on critical health concerns. Dysfunctions in FKBP2 may lead to improper protein folding linked to neurodegenerative conditions like Alzheimer's disease through its interaction with tau proteins. Furthermore its role in calcium regulation ties FKBP2 to cardiovascular disorders where any imbalance can lead to compromised cardiac function suggesting its involvement with cardiac-specific proteins such as SERCA2.