Recombinant Human FKBP52 protein (His tag) is a Human Full Length protein, in the 1 to 459 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M T A E E M K A T E S G A Q S A P L P M E G V D I S P K Q D E G V L K V I K R E G T G T E M P M I G D R V F V H Y T G W L L D G T K F D S S L D R K D K F S F D L G K G E V I K A W D I A I A T M K V G E V C H I T C K P E Y A Y G S A G S P P K I P P N A T L V F E V E L F E F K G E D L T E E E D G G I I R R I Q T R G E G Y A K P N E G A I V E V A L E G Y Y K D K L F D Q R E L R F E I G E G E N L D L P Y G L E R A I Q R M E K G E H S I V Y L K P S Y A F G S V G K E K F Q I P P N A E L K Y E L H L K S F E K A K E S W E M N S E E K L E Q S T I V K E R G T V Y F K E G K Y K Q A L L Q Y K K I V S W L E Y E S S F S N E E A Q K A Q A L R L A S H L N L A M C H L K L Q A F S A A I E S C N K A L E L D S N N E K G L F R R G E A H L A V N D F E L A R A D F Q K V L Q L Y P N N K A A K T Q L A V C Q Q R I R R Q L A R E K K L Y A N M F E R L A E E E N K A K A E A S S G D H P T D T E M K E E Q K S N T A G S Q S Q V E T E A
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
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Target data
Function
Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.
Alternative names
FKBP52, FKBP4, Peptidyl-prolyl cis-trans isomerase FKBP4, PPIase FKBP4, 51 kDa FK506-binding protein, 52 kDa FK506-binding protein, 59 kDa immunophilin, FK506-binding protein 4, FKBP59, HSP-binding immunophilin, Immunophilin FKBP52, Rotamase, FKBP51, 52 kDa FKBP, FKBP-52, p59, FKBP-4, HBI
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Recombinant Human FKBP52 protein (His tag) is a Human Full Length protein, in the 1 to 459 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q02790-1
- Animal free
- No
- Species
- Human
- Reconstitution
- Reconstitute with sterile deionized water to a concentration of 100 µg/ml.
- Concentration
- Storage buffer
pH: 7.4
Constituents: 0.75% Glycine, 0.61% Tris
Sequence info
Amino acid sequence
- M T A E E M K A T E S G A Q S A P L P M E G V D I S P K Q D E G V L K V I K R E G T G T E M P M I G D R V F V H Y T G W L L D G T K F D S S L D R K D K F S F D L G K G E V I K A W D I A I A T M K V G E V C H I T C K P E Y A Y G S A G S P P K I P P N A T L V F E V E L F E F K G E D L T E E E D G G I I R R I Q T R G E G Y A K P N E G A I V E V A L E G Y Y K D K L F D Q R E L R F E I G E G E N L D L P Y G L E R A I Q R M E K G E H S I V Y L K P S Y A F G S V G K E K F Q I P P N A E L K Y E L H L K S F E K A K E S W E M N S E E K L E Q S T I V K E R G T V Y F K E G K Y K Q A L L Q Y K K I V S W L E Y E S S F S N E E A Q K A Q A L R L A S H L N L A M C H L K L Q A F S A A I E S C N K A L E L D S N N E K G L F R R G E A H L A V N D F E L A R A D F Q K V L Q L Y P N N K A A K T Q L A V C Q Q R I R R Q L A R E K K L Y A N M F E R L A E E E N K A K A E A S S G D H P T D T E M K E E Q K S N T A G S Q S Q V E T E A
- Accession
- Q02790
- Protein length
- Full Length
- Predicted molecular weight
- 55.1 kDa
- Amino acids
- 1 to 459
- Nature
- Recombinant
- Tags
- His tag C-Terminus
Specifications
- Form
- Lyophilized
General info
- Function
Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.
- Post-translational modifications
Phosphorylation by CK2 results in loss of HSP90 binding activity.
- Subcellular localisation
- Mitochondrion, Nucleus, Cytoskeleton
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- Up to 12 months
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The immunophilin protein FKBP52 also known as FK506-binding protein 4 (FKBP4) weighs approximately 52 kDa. This protein acts as a peptidyl-prolyl cis-trans isomerase which assists in protein folding and stability. FKBP52 is widely expressed in cells with high levels in tissues like the brain testis and kidneys indicating its role in various cellular processes. As part of its mechanical role FKBP52 interacts with heat shock proteins aiding in the regulation of protein homeostasis.
- Biological function summary
FKBP52 functions as a co-chaperone in steroid receptor complexes. It partners with heat shock protein 90 (HSP90) to form a functional complex that modulates the activity of steroid hormone receptors. These receptors such as the androgen and glucocorticoid receptors rely on FKBP52 for proper regulation and transport within the cell. FKBP52 also plays a part in cellular signaling influencing processes like cell growth and differentiation through its interaction with these receptors.
- Pathways
FKBP52 features prominently in steroid hormone signaling and stress response pathways. It is critical to the maturation and transport of steroid hormone receptors directly affecting their downstream gene regulation. The protein interacts closely with HSP90 and other immunophilins like FKBP51 which also plays roles in similar pathways but may have differing regulatory effects. This interaction demonstrates how FKBP52's function integrates into broader cellular signaling networks influencing pathways like the glucocorticoid receptor signaling pathway.
- Associated diseases and disorders
FKBP52 connects significantly to prostate cancer and Alzheimer's disease. In prostate cancer its modulation of androgen receptor activity is critical. Abnormal regulation of these receptors can contribute to cancer progression. Moreover in Alzheimer's disease FKBP52 influences the stability and function of tau protein which is linked to neurofibrillary tangle formation a hallmark of the disease. Its interaction with tau indicates a potential therapeutic target for intervention in Alzheimer's progression.
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SDS-PAGE - Recombinant Human FKBP52 protein (His tag) (ab219689)
SDS-PAGE analysis of ab219689 under reducing conditions, stained overnight with Coomassie Blue. The reduced protein migrates at 60 kDa.
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