Recombinant Human FLJ12644 protein (His-DHFR tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FLJ12644 also known as LRRC59 is a protein that plays a role in cellular mechanisms. This protein has a molecular mass of approximately 37 kDa. LRRC59 is expressed in multiple tissue types including the liver heart and kidney. It contains leucine-rich repeat domains which facilitate protein-protein interactions. These interactions are essential for the protein's mechanical function in cellular processes.

Biological function summary

The function of LRRC59 influences multiple aspects of cell signaling and homeostasis. It appears to be a part of multiprotein complexes that affect protein localization. These complexes are important for directing proteins to specific cellular compartments. Interaction with other proteins allows LRRC59 to regulate the distribution of signaling molecules within different regions of the cell maintaining efficient cellular communication.

Pathways

LRRC59 serves an important role in the MAPK signaling pathway and the nuclear localization sequence recognition process. The MAPK signaling pathway involves various proteins like ERK which are important for cell proliferation and differentiation. LRRC59 also interacts with importins in guiding proteins into the nucleus. These interactions highlight the role of LRRC59 in dynamic cellular responses and signal propagation.

Alterations in LRRC59 have associations with certain cancer types and neurodegenerative diseases. In cancers LRRC59 may show abnormal expression patterns interacting with proteins like EGFR which is vital in oncogenic signaling. Additionally in neurodegenerative disorders it impacts pathways linked to synaptic function and protein aggregation highlighting potential interactions with proteins such as tau hinting at a role in pathogenesis. Understanding these associations provides a platform for therapeutic exploration.