Recombinant Human FOXI1 protein is a Human Full Length protein, in the 1 to 283 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Images
Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
Amino acid sequence
M S S F D L P A P S P P R C S P Q F P S I G Q E P P E M N L Y Y E N F F H P Q G V P S P Q R P S F E G G G E Y G A T P N P Y L W F N G P T M T P P P Y L P G P N A S P F L P Q A Y G V Q R P L L P S V S G L G G S D L G W L P I P S Q E E L M K L V R P P Y S Y S A L I A M A I H G A P D K R L T L S Q I Y Q Y V A D N F P F Y N K S K A G W Q N S I R H N L S L N D C F K K V P R D E D D P A Y V S G G S P T S H P L V T P G L S P E P S D K T G Q N S L T F N S F S P L T N L S N H S G G G D W A N P M P T N M L S Y G G S V L S Q F S P H F Y N S V N T S G V L Y P R E G T E V
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules (By similarity).
Alternative names
FKHL10, FREAC6, FOXI1, Forkhead box protein I1, Forkhead-related protein FKHL10, Forkhead-related transcription factor 6, Hepatocyte nuclear factor 3 forkhead homolog 3, FREAC-6, HFH-3, HNF-3/fork-head homolog 3
Recommended products
Recombinant Human FOXI1 protein is a Human Full Length protein, in the 1 to 283 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
- Accession
- Q12951-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M S S F D L P A P S P P R C S P Q F P S I G Q E P P E M N L Y Y E N F F H P Q G V P S P Q R P S F E G G G E Y G A T P N P Y L W F N G P T M T P P P Y L P G P N A S P F L P Q A Y G V Q R P L L P S V S G L G G S D L G W L P I P S Q E E L M K L V R P P Y S Y S A L I A M A I H G A P D K R L T L S Q I Y Q Y V A D N F P F Y N K S K A G W Q N S I R H N L S L N D C F K K V P R D E D D P A Y V S G G S P T S H P L V T P G L S P E P S D K T G Q N S L T F N S F S P L T N L S N H S G G G D W A N P M P T N M L S Y G G S V L S Q F S P H F Y N S V N T S G V L Y P R E G T E V
- Accession
- Q12951
- Protein length
- Full Length
- Predicted molecular weight
- 57.2 kDa
- Amino acids
- 1 to 283
- Nature
- Recombinant
Specifications
- Form
- Liquid
General info
- Function
Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules (By similarity).
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The Forkhead box I1 (FOXI1) also known by various alternative names such as HFH3 or FKHL10 is a transcription factor with a mass of approximately 40 kDa. It is predominantly expressed in epithelial tissues including the kidney and inner ear. FOXI1 plays a mechanical role by binding to specific DNA sequences to regulate the transcription of target genes influencing cellular development and differentiation.
- Biological function summary
FOXI1 impacts several fundamental processes including the development of epithelial structures. It acts as a member of the forkhead family of transcription factors known for their roles in cellular growth and differentiation. FOXI1 does not typically form part of a larger protein complex but it interacts with other proteins such as FOXE1 and FGFR2 to execute its biological functions efficiently. These interactions are important for proper organ formation and function.
- Pathways
Several cellular and developmental pathways involve FOXI1. Notably FOXI1 plays an important role in the Wnt signaling pathway essential for cell fate determination and organ development. In this context FOXI1 regulates gene expression by interacting with other pathway components like β-catenin. Additionally FOXI1 participates in the hedgehog signaling pathway where its involvement influences gene transcription in response to developmental cues.
- Associated diseases and disorders
Mutations or dysregulation of FOXI1 have connections to conditions such as distal renal tubular acidosis and sensorineural hearing loss. In distal renal tubular acidosis FOXI1's transcriptional control affects ion channel and transporter expression in the kidney. The disorder links to other proteins like AE1 and H+-ATPase where altered FOXI1 activity influences their expression or function. Sensorineural hearing loss associations with FOXI1 involve its regulatory roles in the inner ear's development affecting auditory function.
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1 product image
SDS-PAGE - Recombinant Human FOXI1 protein (ab132217)
12.5% SDS-PAGE analysis of ab132217 stained with Coomassie Blue.
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