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AB132217

Recombinant Human FOXI1 protein (GST tag N-Terminus)

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Recombinant Human FOXI1 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 283 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

FKHL10, FREAC6, FOXI1, Forkhead box protein I1, Forkhead-related protein FKHL10, Forkhead-related transcription factor 6, Hepatocyte nuclear factor 3 forkhead homolog 3, FREAC-6, HFH-3, HNF-3/fork-head homolog 3

1 Images
SDS-PAGE - Recombinant Human FOXI1 protein (GST tag N-Terminus) (AB132217)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human FOXI1 protein (GST tag N-Terminus) (AB132217)

12.5% SDS-PAGE analysis of ab132217 stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB, SDS-PAGE

applications

Biologically active

No

Accession

Q12951

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Primary Antibodies

AB20454

Anti-FOXI1 antibody

Western blot - Anti-FOXI1 antibody (AB20454)

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Proteins & Peptides

AB101207

Recombinant human PPIL4 protein (His tag N-Terminus)

SDS-PAGE - Recombinant human PPIL4 protein (His tag N-Terminus) (AB101207)

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  • 0
Primary Antibodies

AB181209

Anti-C19orf63 antibody [EPR13223]

RabMAb|Recombinant|KO Validated

Flow Cytometry (Intracellular) - Anti-C19orf63 antibody [EPR13223] (AB181209)

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Primary Antibodies

AB188075

Anti-TCFL5 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TCFL5 antibody (AB188075)

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  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MSSFDLPAPSPPRCSPQFPSIGQEPPEMNLYYENFFHPQGVPSPQRPSFEGGGEYGATPNPYLWFNGPTMTPPPYLPGPNASPFLPQAYGVQRPLLPSVSGLGGSDLGWLPIPSQEELMKLVRPPYSYSALIAMAIHGAPDKRLTLSQIYQYVADNFPFYNKSKAGWQNSIRHNLSLNDCFKKVPRDEDDPAYVSGGSPTSHPLVTPGLSPEPSDKTGQNSLTFNSFSPLTNLSNHSGGGDWANPMPTNMLSYGGSVLSQFSPHFYNSVNTSGVLYPREGTEV","proteinLength":"Full Length","predictedMolecularWeight":"57.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":283,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q12951","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Forkhead box I1 (FOXI1) also known by various alternative names such as HFH3 or FKHL10 is a transcription factor with a mass of approximately 40 kDa. It is predominantly expressed in epithelial tissues including the kidney and inner ear. FOXI1 plays a mechanical role by binding to specific DNA sequences to regulate the transcription of target genes influencing cellular development and differentiation.
Biological function summary

FOXI1 impacts several fundamental processes including the development of epithelial structures. It acts as a member of the forkhead family of transcription factors known for their roles in cellular growth and differentiation. FOXI1 does not typically form part of a larger protein complex but it interacts with other proteins such as FOXE1 and FGFR2 to execute its biological functions efficiently. These interactions are important for proper organ formation and function.

Pathways

Several cellular and developmental pathways involve FOXI1. Notably FOXI1 plays an important role in the Wnt signaling pathway essential for cell fate determination and organ development. In this context FOXI1 regulates gene expression by interacting with other pathway components like β-catenin. Additionally FOXI1 participates in the hedgehog signaling pathway where its involvement influences gene transcription in response to developmental cues.

Mutations or dysregulation of FOXI1 have connections to conditions such as distal renal tubular acidosis and sensorineural hearing loss. In distal renal tubular acidosis FOXI1's transcriptional control affects ion channel and transporter expression in the kidney. The disorder links to other proteins like AE1 and H+-ATPase where altered FOXI1 activity influences their expression or function. Sensorineural hearing loss associations with FOXI1 involve its regulatory roles in the inner ear's development affecting auditory function.
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Specifications

Form

Liquid

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General info

Function

Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules (By similarity).

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Product protocols

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Target data

Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules (By similarity).
See full target information FOXI1
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