Recombinant Human FOXJ2 protein is a Human Full Length protein, in the 1 to 574 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Images
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
M A S D L E S S L T S I D W L P Q L T L R A T I E K L G S A S Q A G P P G S S R K C S P G S P T D P N A T L S K D E A A V H Q D G K P R Y S Y A T L I T Y A I N S S P A K K M T L S E I Y R W I C D N F P Y Y K N A G I G W K N S I R H N L S L N K C F R K V P R P R D D P G K G S Y W T I D T C P D I S R K R R H P P D D D L S Q D S P E Q E A S K S P R G G V A G S G E A S L P P E G N P Q M S L Q S P T S I A S Y S Q G T G S V D G G A V A A G A S G R E S A E G P P P L Y N T N H D F K F S Y S E I N F Q D L S W S F R N L Y K S M L E K S S S S S Q H G F S S L L G D I P P S N N Y Y M Y Q Q Q Q P P P P Q Q Q Q Q Q Q Q P P Q P P P Q Q S Q P Q Q Q Q A P A Q G P S A V G G A P P L H T P S T D G C T P P G G K Q A G A E G Y G P P P V M A M H P P P L Q H G G Y H P H Q H H P H S H P A Q Q P P P P Q P Q A Q G Q A P I N N T G F A F P S D W C S N I D S L K E S F K M V N R L N W S S I E Q S Q F S E L M E S L R Q A E Q K N W T L D Q H H I A N L C D S L N H F L T Q T G H V P P Q G G T H R P P A P A R I A D S C A L T S G K Q E S A M S Q V N S Y G H P Q A P H L Y P G P S P M Y P I P T Q D S A G Y N R P A H H M V P R P S V P P P G A N E E I P D D F D W D L I T
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Isoform FOXJ2.L. Transcriptional activator. Able to bind to two different type of DNA binding sites. More effective than isoform FOXJ2.S in transcriptional activation (PubMed:10777590, PubMed:10966786). Plays an important role in spermatogenesis, especially in spermatocyte meiosis (By similarity). Isoform FOXJ2.S. Transcriptional activator.
Alternative names
FHX, FOXJ2, Forkhead box protein J2, Fork head homologous X
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Recombinant Human FOXJ2 protein is a Human Full Length protein, in the 1 to 574 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- Q9P0K8-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M A S D L E S S L T S I D W L P Q L T L R A T I E K L G S A S Q A G P P G S S R K C S P G S P T D P N A T L S K D E A A V H Q D G K P R Y S Y A T L I T Y A I N S S P A K K M T L S E I Y R W I C D N F P Y Y K N A G I G W K N S I R H N L S L N K C F R K V P R P R D D P G K G S Y W T I D T C P D I S R K R R H P P D D D L S Q D S P E Q E A S K S P R G G V A G S G E A S L P P E G N P Q M S L Q S P T S I A S Y S Q G T G S V D G G A V A A G A S G R E S A E G P P P L Y N T N H D F K F S Y S E I N F Q D L S W S F R N L Y K S M L E K S S S S S Q H G F S S L L G D I P P S N N Y Y M Y Q Q Q Q P P P P Q Q Q Q Q Q Q Q P P Q P P P Q Q S Q P Q Q Q Q A P A Q G P S A V G G A P P L H T P S T D G C T P P G G K Q A G A E G Y G P P P V M A M H P P P L Q H G G Y H P H Q H H P H S H P A Q Q P P P P Q P Q A Q G Q A P I N N T G F A F P S D W C S N I D S L K E S F K M V N R L N W S S I E Q S Q F S E L M E S L R Q A E Q K N W T L D Q H H I A N L C D S L N H F L T Q T G H V P P Q G G T H R P P A P A R I A D S C A L T S G K Q E S A M S Q V N S Y G H P Q A P H L Y P G P S P M Y P I P T Q D S A G Y N R P A H H M V P R P S V P P P G A N E E I P D D F D W D L I T
- Accession
- Q9P0K8
- Protein length
- Full Length
- Amino acids
- 1 to 574
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Isoform FOXJ2.L
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The FOXJ2 protein also known as Forkhead Box J2 functions as a transcription factor that regulates gene expression. It belongs to the forkhead box (FOX) family of transcription factors featuring a conserved forkhead DNA-binding domain. FOXJ2 has a molecular mass of approximately 57 kDa and shows expression in various tissues including the brain liver and testis. FOXJ2 influences transcription processes by binding specific DNA sequences . Genetic studies often study FOXJ2 due to its influence on developmental processes and normal cell function.
- Biological function summary
FOXJ2 controls the expression of genes involved in cell growth differentiation and survival. It forms part of protein complexes that regulate specific gene networks directing cellular responses to developmental and environmental cues. The modulation of gene networks by FOXJ2 impacts processes like neural development and reproductive system functioning. FOXJ2's precise regulation ensures correct cellular outcomes that contribute to complex physiological states which highlights its pivotal role in developmental biology.
- Pathways
FOXJ2 plays essential roles in the Wnt signaling and the PI3K/AKT pathways. In the Wnt signaling pathway FOXJ2 acts as a transcription factor that modulates gene expression helping coordinate cell proliferation and differentiation. FOXJ2 influences the PI3K/AKT pathway by affecting transcriptional programs that promote cell survival and growth. FOXJ2 activity often intersects with other proteins like beta-catenin and AKT1 which also influence these pathways creating a network of interactions essential for maintaining homeostasis and driving developmental processes.
- Associated diseases and disorders
FOXJ2 has links to cancer and neurological disorders. FOXJ2 deregulation contributes to oncogenesis by altering gene expression patterns that lead to uncontrolled cell growth. In particular abnormal FOXJ2 activity can associate with tumor progression in certain carcinomas. Additionally FOXJ2 has connections to neurological disorders where altered expression affects normal brain development and function. Proteins such as beta-catenin in tumors and AKT1 in neurological conditions often interact with FOXJ2 highlighting the tight interplay between FOXJ2 and these proteins in disease contexts.
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1 product image
SDS-PAGE - Recombinant Human FOXJ2 protein (ab153411)
ab153411 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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