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AB158447

Recombinant Human FOXM1 protein (GST tag N-Terminus)

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Recombinant Human FOXM1 protein (GST tag N-Terminus) is a Human Fragment protein, in the 702 to 801 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

FKHL16, HFH11, MPP2, WIN, FOXM1, Forkhead box protein M1, Forkhead-related protein FKHL16, Hepatocyte nuclear factor 3 forkhead homolog 11, M-phase phosphoprotein 2, MPM-2 reactive phosphoprotein 2, Transcription factor Trident, Winged-helix factor from INS-1 cells, HFH-11, HNF-3/fork-head homolog 11

1 Images
SDS-PAGE - Recombinant Human FOXM1 protein (GST tag N-Terminus) (AB158447)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human FOXM1 protein (GST tag N-Terminus) (AB158447)

ab158447 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q08050

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Primary Antibodies

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PD-L1 antibody [28-8] (AB205921)

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Primary Antibodies

AB23738

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Western blot - Anti-FOXA1 + FOXA2 antibody (AB23738)

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Primary Antibodies

AB124691

Anti-IRF4 antibody [EPR5653]

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IRF4 antibody [EPR5653] (AB124691)

  • 4
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"LQSAPPLESPQRLLSSEPLDLISVPFGNSSPSDIDVPKPGSPEPQVSGLAANRSLTEGLVLDTMNDSLSKILLDISFPGLDEDPLGPDNINWSQFIPELQ","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":801,"aminoAcidStart":702,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q08050","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FOXM1 also known as Forkhead Box M1 functions mechanically as a transcription factor. This target plays an important role in the regulation of gene expression during the cell cycle. It is characterized by a molecular weight of approximately 85 kDa. FOXM1 is mainly expressed in actively proliferating cells including the liver lungs and thymus tissues linking it with processes involved in cellular growth and division.
Biological function summary

The transcription factor FOXM1 regulates the expression of genes important for DNA replication and mitosis. It forms part of a complex network with other proteins to initiate and sustain cell proliferation. This protein regulates key regulatory genes such as Cyclin B1 and Plk1 ensuring proper transition through various phases of the cell cycle. The presence of FOXM1 in normal tissues emphasizes its role in maintaining healthy cell division.

Pathways

FOXM1 is integral to the regulation of cell cycle pathways and interacts with proteins involved in the PI3K/AKT signaling pathway. This target coordinates with various proteins to facilitate progression through cell cycle checkpoints and modulate responses to growth signals. Proteins such as CDK1 and SKP2 operate alongside FOXM1 to advance cells from G2 phase into mitosis demonstrating its involvement in cell cycle control mechanics.

FOXM1 shows significant association with cancer progression and metastasis. Overexpression of FOXM1 has been observed in colorectal and breast cancers indicating its potential as a therapeutic target. FOXM1 interacts with proteins like β-catenin in cancerous states influencing tumor growth and survival. Mutations and dysregulation of FOXM1 contribute to oncogenic processes further underlining its role in disease development.
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Specifications

Form

Liquid

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General info

Function

Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed : 19160488, PubMed : 20360045). Plays a role in the control of cell proliferation (PubMed : 19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed : 17101782). Promotes transcription of PHB2 (PubMed : 33754036).

Post-translational modifications

Phosphorylated in M (mitotic) phase (PubMed:17101782, PubMed:19160488, PubMed:30139873). Phosphorylation by the checkpoint kinase CHEK2 in response to DNA damage increases the FOXM1 protein stability probably stimulating the transcription of genes involved in DNA repair (PubMed:17101782). Phosphorylated by CDK1 in late S and G2 phases, creating docking sites for the POLO box domains of PLK1 (PubMed:19160488, PubMed:30139873). Subsequently, PLK1 binds and phosphorylates FOXM1, leading to activation of transcriptional activity and subsequent enhanced expression of key mitotic regulators (PubMed:19160488).

Subcellular localisation

Nucleus

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Product protocols

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Target data

Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed : 19160488, PubMed : 20360045). Plays a role in the control of cell proliferation (PubMed : 19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed : 17101782). Promotes transcription of PHB2 (PubMed : 33754036).
See full target information FOXM1
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Product promise

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