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AB158108

Recombinant Human FOXN3 protein

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Recombinant Human FOXN3 protein is a Human Full Length protein, in the 1 to 468 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

C14orf116, CHES1, FOXN3, Forkhead box protein N3, Checkpoint suppressor 1

1 Images
SDS-PAGE - Recombinant Human FOXN3 protein (AB158108)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human FOXN3 protein (AB158108)

ab158108 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

O00409

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as CHES1.
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Sequence info

[{"sequence":"MGPVMPPSKKPESSGISVSSGLSQCYGGSGFSKALQEDDDLDFSLPDIRLEEGAMEDEELTNLNWLHESKNLLKSFGESVLRSVSPVQDLDDDTPPSPAHSDMPYDARQNPNCKPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERSQSIGKGSLWCIDPEYRQNLIQALKKTPYHPHPHVFNTPPTCPQAYQSTSGPPIWPGSTFFKRNGALLQVPPGVIQNGARVLSRGLFPGVRPLPITPIGVTAAMRNGITSCRMRTESEPSCGSPVVSGDPKEDHNYSSAKSSNARSTSPTSDSISSSSSSADDHYEFATKGSQEGSEGSEGSFRSHESPSDTEEDDRKHSQKEPKDSLGDSGYASQHKKRQHFAKARKVPSDTLPLKKRRTEKPPESDDEEMKEAAGSLLHLAGIRSCLNNITNRTAKGQKEQKETTKN","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":468,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"O00409","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FOXN3 also known as Forkhead Box N3 is a transcription factor that regulates transcription of target genes. The protein belongs to the family of forkhead box transcription factors and possesses a conserved DNA-binding domain. FOXN3 has an approximate molecular weight of 74 kDa. It is expressed in various tissues including the liver heart and kidneys. This protein contributes significantly to cellular stress responses and developmental processes.
Biological function summary

FOXN3 modulates gene expression related to cell cycle control and apoptosis. It acts within a complex to influence the stability and transcriptional activity of other proteins. As part of the MLL complex FOXN3 co-regulates gene expression essential for hematopoietic stem cell maintenance. Through controlling specific target genes it plays a critical role in development and differentiation impacting both normal physiological processes and pathological conditions.

Pathways

FOXN3 is involved in the regulation of the p53 pathway a critical pathway for tumor suppression and cell cycle control. The protein collaborates with p53 to manage stress-induced transcriptional responses. In the NF-kB signaling pathway FOXN3 regulates immune and inflammatory responses positioning itself as an important mediator of immune functions. It interplays with proteins like MLL and p21 emphasizing its significance in these pathways.

FOXN3 associates with cancer particularly breast cancer contributing to its development and progression through aberrant regulation of cell cycle genes. Dysregulation of FOXN3 links to developmental disorders impacting genes that are essential during embryogenesis. In cancer FOXN3 interacts with proteins like BRCA1 amplifying the effects of its dysfunction in tumorigenesis.
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Specifications

Form

Liquid

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General info

Function

Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).

Subcellular localisation

Nucleus

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Product protocols

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Target data

Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).
See full target information FOXN3
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Complementary Products

Primary Antibodies

AB129453

Anti-FOXN3 antibody

Immunoprecipitation - Anti-FOXN3 antibody (AB129453)

  • 5
  • 1
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB137034

Anti-SSRP1 antibody [EPR7895]

RabMAb|Recombinant|Trial Size

Western blot - Anti-SSRP1 antibody [EPR7895] (AB137034)

  • 0
  • 0
Primary Antibodies

AB222515

Anti-CDA antibody [EPR20525]

RabMAb|Recombinant|KO Validated|Trial Size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CDA antibody [EPR20525] (AB222515)

  • 0
  • 0

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