Recombinant Human FOXN3 protein is a Human Full Length protein, in the 1 to 468 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Images
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
M G P V M P P S K K P E S S G I S V S S G L S Q C Y G G S G F S K A L Q E D D D L D F S L P D I R L E E G A M E D E E L T N L N W L H E S K N L L K S F G E S V L R S V S P V Q D L D D D T P P S P A H S D M P Y D A R Q N P N C K P P Y S F S C L I F M A I E D S P T K R L P V K D I Y N W I L E H F P Y F A N A P T G W K N S V R H N L S L N K C F K K V D K E R S Q S I G K G S L W C I D P E Y R Q N L I Q A L K K T P Y H P H P H V F N T P P T C P Q A Y Q S T S G P P I W P G S T F F K R N G A L L Q V P P G V I Q N G A R V L S R G L F P G V R P L P I T P I G V T A A M R N G I T S C R M R T E S E P S C G S P V V S G D P K E D H N Y S S A K S S N A R S T S P T S D S I S S S S S S A D D H Y E F A T K G S Q E G S E G S E G S F R S H E S P S D T E E D D R K H S Q K E P K D S L G D S G Y A S Q H K K R Q H F A K A R K V P S D T L P L K K R R T E K P P E S D D E E M K E A A G S L L H L A G I R S C L N N I T N R T A K G Q K E Q K E T T K N
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).
Alternative names
C14orf116, CHES1, FOXN3, Forkhead box protein N3, Checkpoint suppressor 1
Recommended products
Recombinant Human FOXN3 protein is a Human Full Length protein, in the 1 to 468 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- O00409-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M G P V M P P S K K P E S S G I S V S S G L S Q C Y G G S G F S K A L Q E D D D L D F S L P D I R L E E G A M E D E E L T N L N W L H E S K N L L K S F G E S V L R S V S P V Q D L D D D T P P S P A H S D M P Y D A R Q N P N C K P P Y S F S C L I F M A I E D S P T K R L P V K D I Y N W I L E H F P Y F A N A P T G W K N S V R H N L S L N K C F K K V D K E R S Q S I G K G S L W C I D P E Y R Q N L I Q A L K K T P Y H P H P H V F N T P P T C P Q A Y Q S T S G P P I W P G S T F F K R N G A L L Q V P P G V I Q N G A R V L S R G L F P G V R P L P I T P I G V T A A M R N G I T S C R M R T E S E P S C G S P V V S G D P K E D H N Y S S A K S S N A R S T S P T S D S I S S S S S S A D D H Y E F A T K G S Q E G S E G S E G S F R S H E S P S D T E E D D R K H S Q K E P K D S L G D S G Y A S Q H K K R Q H F A K A R K V P S D T L P L K K R R T E K P P E S D D E E M K E A A G S L L H L A G I R S C L N N I T N R T A K G Q K E Q K E T T K N
- Accession
- O00409
- Protein length
- Full Length
- Amino acids
- 1 to 468
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
This product was previously labelled as CHES1.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
FOXN3 also known as Forkhead Box N3 is a transcription factor that regulates transcription of target genes. The protein belongs to the family of forkhead box transcription factors and possesses a conserved DNA-binding domain. FOXN3 has an approximate molecular weight of 74 kDa. It is expressed in various tissues including the liver heart and kidneys. This protein contributes significantly to cellular stress responses and developmental processes.
- Biological function summary
FOXN3 modulates gene expression related to cell cycle control and apoptosis. It acts within a complex to influence the stability and transcriptional activity of other proteins. As part of the MLL complex FOXN3 co-regulates gene expression essential for hematopoietic stem cell maintenance. Through controlling specific target genes it plays a critical role in development and differentiation impacting both normal physiological processes and pathological conditions.
- Pathways
FOXN3 is involved in the regulation of the p53 pathway a critical pathway for tumor suppression and cell cycle control. The protein collaborates with p53 to manage stress-induced transcriptional responses. In the NF-kB signaling pathway FOXN3 regulates immune and inflammatory responses positioning itself as an important mediator of immune functions. It interplays with proteins like MLL and p21 emphasizing its significance in these pathways.
- Associated diseases and disorders
FOXN3 associates with cancer particularly breast cancer contributing to its development and progression through aberrant regulation of cell cycle genes. Dysregulation of FOXN3 links to developmental disorders impacting genes that are essential during embryogenesis. In cancer FOXN3 interacts with proteins like BRCA1 amplifying the effects of its dysfunction in tumorigenesis.
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1 product image
SDS-PAGE - Recombinant Human FOXN3 protein (ab158108)
ab158108 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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Product protocols
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