Recombinant Human FRA1 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FRA1 also known as FOS-like antigen 1 (FOSL1) is a transcription factor and a part of the AP-1 complex. It weighs about 45 kDa. This protein regulates gene expression linked to cell proliferation differentiation and survival. FRA1 shows expression in various tissues particularly in those undergoing rapid growth and development. The protein mediates immediate early gene response to diverse stimuli.

Biological function summary

In various settings FRA1 serves a role in regulating cellular responses to external signals. It forms a heterodimer with members of the JUN family to create the transcription factor AP-1 complex active in cell cycle regulation and signal transduction. This complex modulates expression of genes involved in processes like hematopoiesis and angiogenesis demonstrating its importance in physiological development and maintenance.

Pathways

The involvement of FRA1 in cellular signaling cascades stands out notably in the MAPK/ERK pathway. This pathway plays a significant role in cell growth and differentiation with FRA1 acting alongside other proteins like ERK to relay signals from surface receptors to the nucleus. Also FRA1 influences the Wnt signaling pathway which impacts cell fate decisions and embryonic development via its interactions and regulatory functions.

Researchers associate FRA1 expression with certain cancers including lung and breast cancer due to its role in controlling cell proliferation and invasion. In cancer FRA1 interacts with proteins like JUN which partner in transforming normal cells into malignant ones through the dysregulation of AP-1 activity. Its role in metastasis highlights FRA1 as a potential biomarker or therapeutic target in oncology.