Recombinant Human FRA2 protein (denatured) is a Human Full Length protein, in the 1 to 326 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE.
Images
Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S M Y Q D Y P G N F D T S S R G S S G S P A H A E S Y S S G G G G Q Q K F R V D M P G S G S A F I P T I N A I T T S Q D L Q W M V Q P T V I T S M S N P Y P R S H P Y S P L P G L A S V P G H M A L P R P G V I K T I G T T V G R R R R D E Q L S P E E E E K R R I R R E R N K L A A A K C R N R R R E L T E K L Q A E T E E L E E E K S G L Q K E I A E L Q K E K E K L E F M L V A H G P V C K I S P E E R R S P P A P G L Q P M R S G G G S V G A V V V K Q E P L E E D S P S S S S A G L D K A Q R S V I K P I S I A G G F Y G E E P L H T P I V V T S T P A V T P G T S N L V F T Y P S V L E Q E S P A S P S E S C S K A H R R S S S S G D Q S S D S L N S P T L L A L
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity).
Alternative names
FRA2, FOSL2, Fos-related antigen 2, FRA-2
Recommended products
Recombinant Human FRA2 protein (denatured) is a Human Full Length protein, in the 1 to 326 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- P15408-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 0.32% Tris HCl
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S M Y Q D Y P G N F D T S S R G S S G S P A H A E S Y S S G G G G Q Q K F R V D M P G S G S A F I P T I N A I T T S Q D L Q W M V Q P T V I T S M S N P Y P R S H P Y S P L P G L A S V P G H M A L P R P G V I K T I G T T V G R R R R D E Q L S P E E E E K R R I R R E R N K L A A A K C R N R R R E L T E K L Q A E T E E L E E E K S G L Q K E I A E L Q K E K E K L E F M L V A H G P V C K I S P E E R R S P P A P G L Q P M R S G G G S V G A V V V K Q E P L E E D S P S S S S A G L D K A Q R S V I K P I S I A G G F Y G E E P L H T P I V V T S T P A V T P G T S N L V F T Y P S V L E Q E S P A S P S E S C S K A H R R S S S S G D Q S S D S L N S P T L L A L
- Accession
- P15408
- Protein length
- Full Length
- Predicted molecular weight
- 37.6 kDa
- Amino acids
- 1 to 326
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab202143 was purified by conventional chromatography techniques.
General info
- Function
Controls osteoclast survival and size (By similarity). As a dimer with JUN, activates LIF transcription (By similarity). Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity).
- Sequence similarities
Belongs to the bZIP family. Fos subfamily.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
FRA2 also known as FOSL2 is a member of the activator protein-1 (AP-1) transcription factor family. It exhibits a molecular mass of approximately 35 kDa. This protein shows expression in various tissues including epithelial and immune cells. FRA2 functions by forming heterodimers with Jun family members influencing gene transcription regulation by binding to DNA at specific AP-1 sites.
- Biological function summary
FRA2 plays a significant role in cellular processes such as differentiation proliferation and apoptosis. It is an integral part of the AP-1 transcription factor complex which regulates the expression of genes linked to cell cycle and stress responses. FRA2 impacts extracellular matrix production and remodeling highlighting its involvement in tissue development and repair.
- Pathways
FRA2 participates in the MAPK signaling pathway an important cascade influencing cell fate decisions. Through this pathway it interacts with proteins like MAPK and ERK which facilitate the transmission of signals from receptors on the cell surface to the DNA in the nucleus. FRA2's participation in the TGF-beta pathway also highlights its role in regulating gene expression associated with growth and differentiation.
- Associated diseases and disorders
FRA2 links to conditions such as cancer and pulmonary fibrosis. It interacts with proteins like Smad3 and Smad4 in the context of cancer progression where it can influence tumor growth and metastasis. In pulmonary fibrosis FRA2 influences fibroblast activation and collagen production contributing to the pathological tissue remodeling seen in the disease.
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1 product image
SDS-PAGE - Recombinant Human FRA2 protein (denatured) (ab202143)
15% SDS-PAGE (ab202143 3 μg)
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