Recombinant Human Frizzled 7 protein (Fc tag C-Terminus)
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Recombinant Human Frizzled 7 protein (Fc tag C-Terminus) is a Human Fragment protein, in the 33 to 185 aa range, expressed in HEK 293 cells, with >90%, suitable for SDS-PAGE.
View Alternative Names
Frizzled-7, Fz-7, hFz7, FzE3, FZD7
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human Frizzled 7 protein (Fc tag C-Terminus) (AB271524)
SDS-PAGE analysis of 2 μg ab271524.
This protein runs at a higher apparent MW by SDS-PAGE due to glycosylation.
Complementary Products
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Frizzled 7 functions in cellular processes such as regulating cell proliferation migration and differentiation. It interacts closely with Dishevelled proteins to activate downstream signaling cascades. As part of a signaling complex Frizzled 7 influences the stabilization and localization of key signaling molecules within the Wnt/β-catenin pathway. This protein's role is vital in maintaining cellular responses necessary for tissue homeostasis and development.
Pathways
Wnt/β-catenin and planar cell polarity pathways are the primary pathways involving Frizzled 7. The Wnt/β-catenin pathway sees this receptor interacting with proteins like LRP5/6 and β-catenin to regulate gene expression. Through these pathways Frizzled 7 helps balance cellular activities that ensure proper tissue growth and repair. These pathways highlight its coordination with other Frizzled receptors to bring about specific cellular responses.
Specifications
Form
Liquid
General info
Function
Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by WNT8 induces expression of beta-catenin target genes (By similarity). Following ligand activation, binds to CCDC88C/DAPLE which displaces DVL1 from FZD7 and leads to inhibition of canonical Wnt signaling, activation of G-proteins by CCDC88C and triggering of non-canonical Wnt responses (PubMed : 26126266). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.. (Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium.
Sequence similarities
Belongs to the G-protein coupled receptor Fz/Smo family.
Post-translational modifications
Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
Subcellular localisation
Endosome membrane
Target data
Product promise
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