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AB207120

Recombinant Human FUCA1 protein

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Recombinant Human FUCA1 protein is a Human Full Length protein, in the 28 to 466 aa range, expressed in Insect cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

Nbla10230, FUCA1, Tissue alpha-L-fucosidase, Alpha-L-fucosidase I, Alpha-L-fucoside fucohydrolase 1, Alpha-L-fucosidase 1

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SDS-PAGE - Recombinant Human FUCA1 protein (AB207120)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human FUCA1 protein (AB207120)

15% SDS-PAGE using ab207120 at 3 μg

Key facts

Purity

>90% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

Insect cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P04066

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS, 10% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"VRRAQPPRRYTPDWPSLDSRPLPAWFDEAKFGVFIHWGVFSVPAWGSEWFWWHWQGEGRPQYQRFMRDNYPPGFSYADFGPQFTARFFHPEEWADLFQAAGAKYVVLTTKHHEGFTNWPSPVSWNWNSKDVGPHRDLVGELGTALRKRNIRYGLYHSLLEWFHPLYLLDKKNGFKTQHFVSAKTMPELYDLVNSYKPDLIWSDGEWECPDTYWNSTNFLSWLYNDSPVKDEVVVNDRWGQNCSCHHGGYYNCEDKFKPQSLPDHKWEMCTSIDKFSWGYRRDMALSDVTEESEIISELVQTVSLGGNYLLNIGPTKDGLIVPIFQERLLAVGKWLSINGEAIYASKPWRVQWEKNTTSVWYTSKGSAVYAIFLHWPENGVLNLESPITTSTTKITMLGIQGDLKWSTDPDKGLFISLPQLPPSAVPAEFAWTIKLTGVKHHHHHH","proteinLength":"Full Length","predictedMolecularWeight":"51.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":466,"aminoAcidStart":28,"nature":"Recombinant","expressionSystem":"Insect cells","accessionNumber":"P04066","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein known as 'alpha-L-fucosidase' or more commonly 'FUCA1' works as an enzyme breaking down complex carbohydrates by removing terminal alpha-L-fucose residues. This enzyme weighs approximately 51 kDa. It mainly expresses in tissues such as the liver pancreas and kidney playing a role in glycoprotein metabolism. Sometimes researchers refer to it simply as 'fucosidase' reflecting its central activity in fucose metabolism.
Biological function summary

FUCA1 impacts various cellular functions through its role in glycan processing. This enzyme is not typically part of a larger complex working independently to hydrolyze glycosidic bonds. Its action is important in the catabolism of fucosylated glycoproteins and glycolipids influencing cell signaling and recognition. Alterations in FUCA1 activity can disrupt these processes affecting cellular homeostasis.

Pathways

FUCA1 plays a role in the metabolism of glycosaminoglycans and glycoproteins. It contributes to the lysosomal degradation pathway alongside related enzymes such as beta-galactosidase. FUCA1's activity ensures the correct recycling of glycoproteins maintaining the balance of cellular components. The defect or overactivity of FUCA1 may have cascading effects throughout these pathways linking it with potential metabolic imbalances.

FUCA1 connects closely with fucosidosis a lysosomal storage disorder caused by FUCA1 deficiency. This leads to an accumulation of fucose-containing compounds resulting in progressive neurological decline. Additionally some studies suggest a link between altered FUCA1 expression and certain cancers due to its role in cellular recognition and signaling. In cancer this enzyme's interaction with other glycoprotein-processing enzymes becomes highlighted highlighting the complex interplay within disease contexts.
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Specifications

Form

Liquid

Additional notes

Affinity purified

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General info

Function

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

Sequence similarities

Belongs to the glycosyl hydrolase 29 family.

Subcellular localisation

Lysosome

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Product protocols

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Target data

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
See full target information FUCA1
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Product promise

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