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AB187614

Recombinant Human FUCA2 protein (denatured) (His tag N-Terminus)

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Recombinant Human FUCA2 protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 29 to 467 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

PSEC0151, UNQ227/PRO260, FUCA2, Plasma alpha-L-fucosidase, Alpha-L-fucoside fucohydrolase 2, Alpha-L-fucosidase 2

1 Images
SDS-PAGE - Recombinant Human FUCA2 protein (denatured) (His tag N-Terminus) (AB187614)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human FUCA2 protein (denatured) (His tag N-Terminus) (AB187614)

15% SDS-PAGE analysis of ab187614 (3μg).

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9BTY2

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: PBS, 10% Glycerol (glycerin, glycerine)

storage-buffer

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Complementary Products

Assay Kits

AB272525

alpha-L-Fucosidase Assay Kit

Enzyme activity assay - alpha-L-Fucosidase Assay Kit (AB272525)

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Primary Antibodies

AB169480

Anti-FUCA2 antibody

Western blot - Anti-FUCA2 antibody (AB169480)

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  • 0
Cell Lines & Lysates

AB263205

Human FUCA2 knockout HEK-293T cell lysate

Sanger Sequencing - Human FUCA2 knockout HEK-293T cell lysate (AB263205)

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Cell Lines & Lysates

AB266754

Human FUCA2 knockout HEK-293T cell line

Sanger Sequencing - Human FUCA2 knockout HEK-293T cell line (AB266754)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHSATRFDPTWESLDARQLPAWFDQAKFGIFIHWGVFSVPSFGSEWFWWYWQKEKIPKYVEFMKDNYPPSFKYEDFGPLFTAKFFNANQWADIFQASGAKYIVLTSKHHEGFTLWGSEYSWNWNAIDEGPKRDIVKELEVAIRNRTDLRFGLYYSLFEWFHPLFLEDESSSFHKRQFPVSKTLPELYELVNNYQPEVLWSDGDGGAPDQYWNSTGFLAWLYNESPVRGTVVTNDRWGAGSICKHGGFYTCSDRYNPGHLLPHKWENCMTIDKLSWGYRREAGISDYLTIEELVKQLVETVSCGGNLLMNIGPTLDGTISVVFEERLRQMGSWLKVNGEAIYETHTWRSQNDTVTPDVWYTSKPKEKLVYAIFLKWPTSGQLFLGHPKAILGATEVKLLGHGQPLNWISLEQNGIMVELPQLTIHQMPCKWGWALALTNVI","proteinLength":"Full Length","predictedMolecularWeight":"53.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":467,"aminoAcidStart":29,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9BTY2","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The FUCA2 protein also known as plasma alpha-L-fucosidase 2 acts mechanically by hydrolyzing the alpha-16-linked fucose residues from glycoproteins and glycolipids. FUCA2 weighs approximately 53 kDa and localizes mainly to the human liver and blood plasma. Its enzymatic activity helps maintain proper cell surface carbohydrate structures which play important roles in cell-cell communication and adhesion.
Biological function summary

FUCA2 participates in the degradation of fucosylated glycoconjugates. It does not form part of a larger complex; however it operates in concert with other glycosidases to ensure efficient turnover of glycoproteins and glycolipids. This turnover is important in maintaining cellular and systemic homeostasis influencing processes like immune response and inflammatory regulation.

Pathways

FUCA2 is involved in the lysosomal degradation pathway and also interacts within the glycosphingolipid metabolism pathway. It cooperates with proteins like alpha-L-fucosidase 1 (FUCA1) to facilitate the catabolism of glycostructures. These metabolic pathways are essential for recycling cellular materials and processing complex sugar molecules highlighting their role in maintaining cellular efficiency.

FUCA2 presents a connection with fucosidosis and certain cancers such as hepatocellular carcinoma. Its dysfunction can lead to abnormal accumulation of fucosylated compounds contributing to the development of lysosomal storage disorders. In cancer its activity coupled with proteins like alpha-L-fucosidase 3 (FUCA3) may affect the tumor microenvironment influencing cancer cell proliferation and metastasis through altered glycosylation patterns.
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Specifications

Form

Liquid

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General info

Function

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

Sequence similarities

Belongs to the glycosyl hydrolase 29 family.

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Product protocols

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Target data

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
See full target information FUCA2
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