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AB164533

Recombinant Human FYTTD1 protein

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(1 Publication)

Recombinant Human FYTTD1 protein is a Human Full Length protein, in the 1 to 318 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

UIF, FYTTD1, UAP56-interacting factor, Forty-two-three domain-containing protein 1, Protein 40-2-3

1 Images
SDS-PAGE - Recombinant Human FYTTD1 protein (AB164533)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human FYTTD1 protein (AB164533)

ab164533 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q96QD9

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MNRFGTRLVGATATSSPPPKARSNENLDKIDMSLDDIIKLNRKEGKKQNFPRLNRRLLQQSGAQQFRMRVRWGIQQNSGFGKTSLNRRGRVMPGKRRPNGVITGLAARKTTGIRKGISPMNRPPLSDKNIEQYFPVLKRKANLLRQNEGQRKPVAVLKRPSQLSRKNNIPANFTRSGNKLNHQKDTRQATFLFRRGLKVQAQLNTEQLLDDVVAKRTRQWRTSTTNGGILTVSIDNPGAVQCPVTQKPRLTRTAVPSFLTKREQSDVKKVPKGVPLQFDINSVGKQTGMTLNERFGILKEQRATLTYNKGGSRFVTVG","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":318,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q96QD9","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

FYTTD1 also known as UIF or U2AF65-interacting factor plays an essential role mechanically within the spliceosome. The protein has a molecular mass of approximately 63 kDa. FYTTD1 expresses widely across human tissues but shows higher expression in the nucleoplasm of cells. The protein facilitates interactions in pre-mRNA splicing by associating with other components of the spliceosomal complex which is critical for mRNA processing.
Biological function summary

FYTTD1 influences pre-mRNA splicing by forming part of the spliceosome complex. Research shows it interacts with U2AF65 a splicing factor necessary for promoting the assembly of the spliceosome complex on pre-mRNA. FYTTD1 ensures proper exon recognition and the removal of introns contributing to mRNA maturation. Its function is vital within the spliceosomal machinery maintaining the fidelity of gene expression.

Pathways

FYTTD1 supports efficient splicing and processing of pre-mRNA which directly affects mRNA transcript stability and protein synthesis pathways. It ties closely to the spliceosomal pathway and the gene expression regulation process. FYTTD1 works alongside proteins like U2AF65 and SF3B1 illustrating its participation in complex splicing mechanisms that regulate cellular metabolic activities and genome stability.

FYTTD1 is implicated in conditions such as cancer and neurodegenerative disorders. Abnormal splicing involving FYTTD1 can lead to aberrations in gene expression contributing to oncogenesis or faulty neuronal functioning. Studies link FYTTD1 dysregulation with changes in other proteins like SF3B1 and U2AF65 which exhibit altered activity in various cancers and neurological conditions highlighting the importance of its regulated expression.
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Specifications

Form

Liquid

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General info

Function

Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4.

Sequence similarities

Belongs to the UIF family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4.
See full target information FYTTD1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell 173:260-274.e25 PubMed29551266

2018

Multiplexed Proteome Dynamics Profiling Reveals Mechanisms Controlling Protein Homeostasis.

Applications

Unspecified application

Species

Unspecified reactive species

Mikhail M Savitski,Nico Zinn,Maria Faelth-Savitski,Daniel Poeckel,Stephan Gade,Isabelle Becher,Marcel Muelbaier,Anne J Wagner,Katrin Strohmer,Thilo Werner,Stephanie Melchert,Massimo Petretich,Anna Rutkowska,Johanna Vappiani,Holger Franken,Michael Steidel,Gavain M Sweetman,Omer Gilan,Enid Y N Lam,Mark A Dawson,Rab K Prinjha,Paola Grandi,Giovanna Bergamini,Marcus Bantscheff
View all publications
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