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Recombinant Human G gamma12 protein (denatured) is a Human Full Length protein, in the 1 to 69 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE.

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Images

SDS-PAGE - Recombinant Human G gamma12 protein (denatured) (AB202183), expandable thumbnail

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

Biologically active

No

Amino acid sequence

M G S S H H H H H H S S G L V P R G S H M G S M S S K T A S T N N I A Q A R R T V Q Q L R L E A S I E R I K V S K A S A D L M S Y C E E H A R S D P L L I G I P T S E N P F K D K K T C

Reactivity data

Application

SDS-PAGE

Reactivity

Reacts

Dilution info

-

Notes

-

Target data

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Alternative names

Recommended products

Recombinant Human G gamma12 protein (denatured) is a Human Full Length protein, in the 1 to 69 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Applications

SDS-PAGE

Accession
Q9UBI6-1
Animal free

No

Species

Human

Concentration
Loading...
Storage buffer

pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 0.32% Tris HCl

Sequence info

Amino acid sequence

M G S S H H H H H H S S G L V P R G S H M G S M S S K T A S T N N I A Q A R R T V Q Q L R L E A S I E R I K V S K A S A D L M S Y C E E H A R S D P L L I G I P T S E N P F K D K K T C

Accession

Q9UBI6

Protein length

Full Length

Predicted molecular weight

10.1 kDa

Amino acids

1 to 69

Nature

Recombinant

Tags

His tag N-Terminus

Specifications

Form

Liquid

General info

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Sequence similarities

Belongs to the G protein gamma family.

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The G gamma12 protein also known as guanine nucleotide-binding protein subunit gamma 12 is a component of the heterotrimeric G proteins. It has an approximate molecular mass of 8 kDa. This protein predominantly resides at the plasma membrane where it partners with its associated G alpha and G beta subunits. G gamma12 shows expression in various tissues including the brain and heart where it functions as an integral part of signal transduction processes.

Biological function summary

G gamma12 is involved in transmitting signals within cells by interacting with its G alpha and G beta counterparts to form a functional G protein complex. This complex plays a critical role in modulating and transducing signals from activated cell surface receptors to downstream effectors. As a member of the G protein gamma subunit family G gamma12 aids in diverse cellular responses such as cell growth differentiation and motility.

Pathways

G gamma12 plays a part in the MAPK signaling pathway and the PI3K-Akt signaling pathway. These pathways are significant for regulating various cellular activities like survival and metabolism. Proteins like G beta and specific G alpha subunits closely interact with G gamma12 in these pathways influencing the downstream signaling cascades and cellular responses.

Associated diseases and disorders

G gamma12 has associations with cancer and cardiovascular diseases. In the context of cancer altered G gamma12 expression affects cell proliferation and migration thereby contributing to tumor development. In cardiovascular diseases it implicates processes such as heart rate regulation. Through these conditions G gamma12 connects to other proteins like G alpha q and beta-adrenergic receptors contributing to the disease state's pathophysiology.

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1 product image

  • SDS-PAGE - Recombinant Human G gamma12 protein (denatured) (ab202183), expandable thumbnail

    SDS-PAGE - Recombinant Human G gamma12 protein (denatured) (ab202183)

    15% SDS-PAGE analysis of ab202183 (3 μg).

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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