Recombinant Human G gamma12 protein (denatured) is a Human Full Length protein, in the 1 to 69 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE.
>85% SDS-PAGE
Escherichia coli
His tag N-Terminus
SDS-PAGE
No
M G S S H H H H H H S S G L V P R G S H M G S M S S K T A S T N N I A Q A R R T V Q Q L R L E A S I E R I K V S K A S A D L M S Y C E E H A R S D P L L I G I P T S E N P F K D K K T C
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12, GNG12
Recombinant Human G gamma12 protein (denatured) is a Human Full Length protein, in the 1 to 69 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE.
>85% SDS-PAGE
Escherichia coli
His tag N-Terminus
SDS-PAGE
No
No
Human
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 0.32% Tris HCl
M G S S H H H H H H S S G L V P R G S H M G S M S S K T A S T N N I A Q A R R T V Q Q L R L E A S I E R I K V S K A S A D L M S Y C E E H A R S D P L L I G I P T S E N P F K D K K T C
Full Length
10.1 kDa
1 to 69
Recombinant
His tag N-Terminus
Liquid
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Belongs to the G protein gamma family.
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
This supplementary information is collated from multiple sources and compiled automatically.
The G gamma12 protein also known as guanine nucleotide-binding protein subunit gamma 12 is a component of the heterotrimeric G proteins. It has an approximate molecular mass of 8 kDa. This protein predominantly resides at the plasma membrane where it partners with its associated G alpha and G beta subunits. G gamma12 shows expression in various tissues including the brain and heart where it functions as an integral part of signal transduction processes.
G gamma12 is involved in transmitting signals within cells by interacting with its G alpha and G beta counterparts to form a functional G protein complex. This complex plays a critical role in modulating and transducing signals from activated cell surface receptors to downstream effectors. As a member of the G protein gamma subunit family G gamma12 aids in diverse cellular responses such as cell growth differentiation and motility.
G gamma12 plays a part in the MAPK signaling pathway and the PI3K-Akt signaling pathway. These pathways are significant for regulating various cellular activities like survival and metabolism. Proteins like G beta and specific G alpha subunits closely interact with G gamma12 in these pathways influencing the downstream signaling cascades and cellular responses.
G gamma12 has associations with cancer and cardiovascular diseases. In the context of cancer altered G gamma12 expression affects cell proliferation and migration thereby contributing to tumor development. In cardiovascular diseases it implicates processes such as heart rate regulation. Through these conditions G gamma12 connects to other proteins like G alpha q and beta-adrenergic receptors contributing to the disease state's pathophysiology.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
15% SDS-PAGE analysis of ab202183 (3 μg).
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com