Recombinant Human G6b protein (Fc Chimera) is a Human Fragment protein, in the 1 to 146 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- Fc tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M A V F L Q L L P L L L S R A Q G N P G A S L D G R P G D R V N L S C G G V S H P I R W V W A P S F P A C K G L S K G R R P I L W A S S S G T P T V P P L Q P F V G R L R S L D S G I R R L E L L L S A G D S G T F F C K G R H E D E S R T V L H V L G D R T Y C K A P G P T H G S V Y P Q L L I P
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production (PubMed:12665801, PubMed:17311996, PubMed:27743390). Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide (PubMed:12665801). This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling (PubMed:17311996). Appears to operate in a calcium-independent manner (PubMed:12665801). Isoform B, displayed in this entry, is the only isoform to contain both a transmembrane region and 2 immunoreceptor tyrosine-based inhibitor motifs (ITIMs) and, thus, the only one which probably has a role of inhibitory receptor. Isoform A may be the activating counterpart of isoform B.
Alternative names
C6orf25, G6B, G6B-B, MPIG6B, Megakaryocyte and platelet inhibitory receptor G6b, Protein G6b
Recommended products
Recombinant Human G6b protein (Fc Chimera) is a Human Fragment protein, in the 1 to 146 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- Fc tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- O95866-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 100% PBS
Sequence info
Amino acid sequence
- M A V F L Q L L P L L L S R A Q G N P G A S L D G R P G D R V N L S C G G V S H P I R W V W A P S F P A C K G L S K G R R P I L W A S S S G T P T V P P L Q P F V G R L R S L D S G I R R L E L L L S A G D S G T F F C K G R H E D E S R T V L H V L G D R T Y C K A P G P T H G S V Y P Q L L I P
- Accession
- O95866
- Protein length
- Fragment
- Predicted molecular weight
- 40.2 kDa
- Amino acids
- 1 to 146
- Nature
- Recombinant
- Tags
- Fc tag C-Terminus
Specifications
- Form
- Lyophilized
General info
- Function
Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production (PubMed:12665801, PubMed:17311996, PubMed:27743390). Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide (PubMed:12665801). This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling (PubMed:17311996). Appears to operate in a calcium-independent manner (PubMed:12665801).
- Post-translational modifications
All isoforms are N-glycosylated.
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Product promise
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1 product image
SDS-PAGE - Recombinant Human G6b protein (Fc Chimera) (ab276378)
SDS-PAGE analysis of ab276378
Downloads
Product protocols
- Visit the general protocols
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