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AB276378

Recombinant Human G6b protein (Fc Chimera)

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Recombinant Human G6b protein (Fc Chimera) is a Human Fragment protein, in the 1 to 146 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

C6orf25, G6B, G6B-B, MPIG6B, Megakaryocyte and platelet inhibitory receptor G6b, Protein G6b

1 Images
SDS-PAGE - Recombinant Human G6b protein (Fc Chimera) (AB276378)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human G6b protein (Fc Chimera) (AB276378)

SDS-PAGE analysis of ab276378

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

Fc tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

O95866

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MAVFLQLLPLLLSRAQGNPGASLDGRPGDRVNLSCGGVSHPIRWVWAPSFPACKGLSKGRRPILWASSSGTPTVPPLQPFVGRLRSLDSGIRRLELLLSAGDSGTFFCKGRHEDESRTVLHVLGDRTYCKAPGPTHGSVYPQLLIP","proteinLength":"Fragment","predictedMolecularWeight":"40.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":146,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"O95866","tags":[{"tag":"Fc","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Specifications

Form

Lyophilized

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General info

Function

Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production (PubMed : 12665801, PubMed : 17311996, PubMed : 27743390). Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide (PubMed : 12665801). This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6 : FcRgamma signaling (PubMed : 17311996). Appears to operate in a calcium-independent manner (PubMed : 12665801).. Isoform B, displayed in this entry, is the only isoform to contain both a transmembrane region and 2 immunoreceptor tyrosine-based inhibitor motifs (ITIMs) and, thus, the only one which probably has a role of inhibitory receptor. Isoform A may be the activating counterpart of isoform B.

Post-translational modifications

All isoforms are N-glycosylated.. Isoform E is O-glycosylated.. Phosphorylated.

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Product protocols

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Target data

Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production (PubMed : 12665801, PubMed : 17311996, PubMed : 27743390). Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide (PubMed : 12665801). This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6 : FcRgamma signaling (PubMed : 17311996). Appears to operate in a calcium-independent manner (PubMed : 12665801).. Isoform B, displayed in this entry, is the only isoform to contain both a transmembrane region and 2 immunoreceptor tyrosine-based inhibitor motifs (ITIMs) and, thus, the only one which probably has a role of inhibitory receptor. Isoform A may be the activating counterpart of isoform B.
See full target information MPIG6B
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Product promise

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