Recombinant Human Galectin 1 protein is a Human Full Length protein, in the 2 to 135 aa range, expressed in HEK 293, with >=95% purity and suitable for SDS-PAGE.
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Key facts
- Purity
>=95% SDS-PAGE
- Expression system
HEK 293 cells
- Tags
Tag free
- Applications
SDS-PAGE
- Biologically active
No
Amino acid sequence
A C G L V A S N L N L K P G E C L R V R G E V A P D A K S F V L N L G K D S N N L C L H F N P R F N A H G D A N T I V C N S K D G G A W G T E Q R E A V F P F Q P G S V A E V C I T F D Q A N L T V K L P D G Y E F K F P N R L N L E A I N Y M A A D G D F K I K C V A F D
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.
Alternative names
Galectin-1, Gal-1, 14 kDa laminin-binding protein, 14 kDa lectin, Beta-galactoside-binding lectin L-14-I, Galaptin, HBL, HPL, Lactose-binding lectin 1, Lectin galactoside-binding soluble 1, Putative MAPK-activating protein PM12, S-Lac lectin 1, HLBP14, LGALS1
Recommended products
Recombinant Human Galectin 1 protein is a Human Full Length protein, in the 2 to 135 aa range, expressed in HEK 293, with >=95% purity and suitable for SDS-PAGE.
Key facts
- Purity
>=95% SDS-PAGE
- Expression system
HEK 293 cells
- Tags
Tag free
- Applications
SDS-PAGE
- Biologically active
No
- Accession
- P09382-1
- Animal free
Yes
- Carrier free
Yes
- Species
Human
- Reconstitution
Reconstitute in PBS
- Concentration
- Storage buffer
pH: 7.4
Constituents: 10.26% Trehalose, 0.727% Dibasic monohydrogen potassium phosphate, 0.248% Potassium phosphate monobasic
Sequence info
Amino acid sequence
A C G L V A S N L N L K P G E C L R V R G E V A P D A K S F V L N L G K D S N N L C L H F N P R F N A H G D A N T I V C N S K D G G A W G T E Q R E A V F P F Q P G S V A E V C I T F D Q A N L T V K L P D G Y E F K F P N R L N L E A I N Y M A A D G D F K I K C V A F D
- Accession
- Protein length
Full Length
- Predicted molecular weight
14.64 kDa
- Amino acids
2 to 135
- Nature
Recombinant
Specifications
- Form
Lyophilized
General info
- Function
Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
Ambient
- Appropriate long-term storage conditions
Ambient
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Galectin-1 also referred to as GAL1 or galectin 1 is a protein with a molecular mass of approximately 14.5 kDa. It belongs to a group called the beta-galactoside-binding lectins and is typically characterized by its distinct carbohydrate-recognition domain. Galectin-1 is expressed in a variety of tissues including muscle epithelial cells the nervous system and immune cells. In particular high expression levels are found in the placenta and the thymus indicating a role in development and immune function.
- Biological function summary
This protein mediates a variety of cellular processes such as cell differentiation apoptosis and immune cell modulation. As a monomer galectin-1 binds specifically to beta-galactoside residues on the cell surface. It plays a significant role in regulation of cell signaling circuits affecting T-cell activation as well as macrophage function. The Galectin-1 protein does not commonly form complexes but can influence interactions of other proteins by binding to glycoproteins on the cell surface which can modulate signaling outcomes.
- Pathways
The protein is actively involved in pathways related to cell-cell interactions and immune modulation. It interacts with pathways like Ras signaling which is fundamental in cell growth proliferation and survival. Through these pathways galectin-1 is closely related to other proteins including Ras and Raf which are critical in transmitting signals from the cell surface to the DNA in the nucleus affecting gene expression involved in apoptosis and autophagy.
- Associated diseases and disorders
Galectin-1 association with cancer progression and autoimmune diseases reflects its role in immune system regulation. High galectin-1 levels have been recorded in various tumors where the protein promotes tumor progression by supporting angiogenesis and suppressing immune response against cancer cells. In autoimmune disorders such as multiple sclerosis modulation of Galectin-1 levels can alter disease progression and the immune system’s behavior. The protein interacts with other key regulators like cytokines emphasizing its importance in immune-inflammatory pathways and potential as a therapeutic target.
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1 product image
SDS-PAGE - Recombinant Human Galectin 1 protein (ab283440)
SDS-PAGE analysis of ab283440.
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