Recombinant Human Galectin 8/Gal-8 protein (His tag N-Terminus)
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Recombinant Human Galectin 8/Gal-8 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 317 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec, WB.
View Alternative Names
Galectin-8, Gal-8, Po66 carbohydrate-binding protein, Prostate carcinoma tumor antigen 1, Po66-CBP, PCTA-1, LGALS8
- WB
Unknown
Western blot - Recombinant Human Galectin 8/Gal-8 protein (His tag N-Terminus) (AB99294)
All lanes:
Western blot - Anti-Galectin 8/Gal-8 antibody [EPR4857] (<a href='/en-us/products/primary-antibodies/galectin-8-gal-8-antibody-epr4857-ab109519'>ab109519</a>) at 1/5000 dilution
All lanes:
Western blot - Recombinant Human Galectin 8/Gal-8 protein (His tag N-Terminus) (ab99294) at 0.1 µg
Secondary
All lanes:
Western blot - Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-preadsorbed-ab97080'>ab97080</a>) at 1/5000 dilution
Predicted band size: 36 kDa
true
Exposure time: 90s
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human Galectin 8/Gal-8 protein (His tag N-Terminus) (AB99294)
15% SDS-PAGE showing ab99294 (3μg).
Reactivity data
Product details
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Galectin-8 impacts numerous cellular functions through its involvement in immunomodulation and cell migration. Gal-8 promotes adhesion between cells and the extracellular matrix. It is not a part of a larger protein complex but interacts with multiple cell surface receptors guiding them toward or away from specific locations. Galectins including Galectin-8 influence immune cell responses by managing the apoptosis of T-cells and modifying cytokine production.
Pathways
Galectin-8 engages in signaling pathways related to cellular adhesion and immune system modulation. It participates in the integrin-mediated cell adhesion pathway and contributes to the receptor signaling pathway associated with cytokines. Within these pathways Galectin-8 interacts with other proteins such as integrins and T-cell receptors influencing their activation internalization and cell surface retention.
Specifications
Form
Liquid
Additional notes
ab99294 is purified using conventional chromatography techniques.
General info
Function
Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy (PubMed : 22246324, PubMed : 28077878). Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture (PubMed : 22246324, PubMed : 28077878). Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52 (PubMed : 22246324, PubMed : 28077878). Required to restrict infection of bacterial invasion such as S.typhimurium (PubMed : 22246324). Also required to restrict infection of Picornaviridae viruses (PubMed : 28077878). Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans (PubMed : 21288902).
Target data
Complementary Products
Product promise
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