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AB139613

Recombinant Human GALT protein

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Recombinant Human GALT protein is a Human Full Length protein, in the 1 to 379 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

Galactose-1-phosphate uridylyltransferase, Gal-1-P uridylyltransferase, UDP-glucose--hexose-1-phosphate uridylyltransferase, GALT

1 Images
SDS-PAGE - Recombinant Human GALT protein (AB139613)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human GALT protein (AB139613)

15% SDS-PAGE analysis of ab139613 (3μg).

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

P07902

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8.5 Constituents: 10% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMSRSGTDPQQRQQASEADAAAATFRANDHQHIRYNPLQDEWVLVSAHRMKRPWQGQVEPQLLKTVPRHDPLNPLCPGAIRANGEVNPQYDSTFLFDNDFPALQPDAPSPGPSDHPLFQAKSARGVCKVMCFHPWSDVTLPLMSVPEIRAVVDAWASVTEELGAQYPWVQIFENKGAMMGCSNPHPHCQVWASSFLPDIAQREERSQQAYKSQHGEPLLMEYSRQELLRKERLVLTSEHWLVLVPFWATWPYQTLLLPRRHVRRLPELTPAERDDLASIMKKLLTKYDNLFETSFPYSMGWHGAPTGSEAGANWNHWQLHAHYYPPLLRSATVRKFMVGYEMLAQAQRDLTPEQAAERLRALPEVHYHLGQKDRETATIA","proteinLength":"Full Length","predictedMolecularWeight":"45.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":379,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P07902","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GALT also known as galactose-1-phosphate uridyltransferase is an enzyme involved in the Leloir pathway of galactose metabolism. The GALT protein facilitates the conversion of galactose-1-phosphate (Gal-1-P) and UDP-glucose to UDP-galactose and glucose-1-phosphate important steps in the cellular utilization of galactose. This enzyme has a molecular mass of approximately 43 kDa. GALT is expressed in various tissues and is notably present in the liver and erythrocytes where efficient galactose metabolism is essential.
Biological function summary

GALT plays a role in carbohydrate metabolism by regulating galactose conversion to glucose a principal energy source. It does not form part of a complex but works alongside other enzymes such as galactokinase and UDP-galactose 4'-epimerase in the Leloir pathway. This enzymatic action ensures that galactose from food sources is metabolized properly contributing to overall energy homeostasis within the body.

Pathways

GALT participates in the Leloir pathway which is essential for the breakdown and utilization of galactose. Through this pathway GALT interacts indirectly with related proteins like galactokinase and UDP-galactose 4'-epimerase. This enzymatic pathway is linked to complex carbohydrate metabolism and feeds into broader glucose metabolism processes underlining its importance in maintaining glucose levels.

GALT is linked to classic galactosemia a rare genetic metabolic disorder. This condition arises from an impairment in the GALT enzyme leading to toxic accumulation of galactose-1-phosphate in the body. Individuals with classic galactosemia often experience symptoms like jaundice liver enlargement and can develop cataracts or mental developmental issues if not treated early. In the context of this disorder proteins such as galactokinase also play a role since they are upstream in the metabolic pathway that leads to the problematic accumulation.
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Specifications

Form

Liquid

Additional notes

ab139613 is purified using conventional chromatography techniques.

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General info

Function

Plays an important role in galactose metabolism.

Sequence similarities

Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.

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Product protocols

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Target data

Plays an important role in galactose metabolism.
See full target information GALT
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Complementary Products

Primary Antibodies

AB178406

Anti-GALT antibody [EPR12555]

RabMAb|Recombinant|KO Validated

Western blot - Anti-GALT antibody [EPR12555] (AB178406)

  • 0
  • 0
Primary Antibodies

AB84340

Anti-Golgin 97 antibody

BOND RX™ Validated

Immunocytochemistry/ Immunofluorescence - Anti-Golgin 97 antibody (AB84340)

  • 5
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Primary Antibodies

AB229639

Anti-COPB2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COPB2 antibody (AB229639)

  • 0
  • 0
Primary Antibodies

AB224155

Anti-PAICS/PAIS antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PAICS/PAIS antibody (AB224155)

  • 0
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