Recombinant Human GALT protein is a Human Full Length protein, in the 1 to 379 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE, MS.
Images
Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S H M S R S G T D P Q Q R Q Q A S E A D A A A A T F R A N D H Q H I R Y N P L Q D E W V L V S A H R M K R P W Q G Q V E P Q L L K T V P R H D P L N P L C P G A I R A N G E V N P Q Y D S T F L F D N D F P A L Q P D A P S P G P S D H P L F Q A K S A R G V C K V M C F H P W S D V T L P L M S V P E I R A V V D A W A S V T E E L G A Q Y P W V Q I F E N K G A M M G C S N P H P H C Q V W A S S F L P D I A Q R E E R S Q Q A Y K S Q H G E P L L M E Y S R Q E L L R K E R L V L T S E H W L V L V P F W A T W P Y Q T L L L P R R H V R R L P E L T P A E R D D L A S I M K K L L T K Y D N L F E T S F P Y S M G W H G A P T G S E A G A N W N H W Q L H A H Y Y P P L L R S A T V R K F M V G Y E M L A Q A Q R D L T P E Q A A E R L R A L P E V H Y H L G Q K D R E T A T I A
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Alternative names
Galactose-1-phosphate uridylyltransferase, Gal-1-P uridylyltransferase, UDP-glucose--hexose-1-phosphate uridylyltransferase, GALT
Recommended products
Recombinant Human GALT protein is a Human Full Length protein, in the 1 to 379 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- P07902-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8.5
Constituents: 10% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S H M S R S G T D P Q Q R Q Q A S E A D A A A A T F R A N D H Q H I R Y N P L Q D E W V L V S A H R M K R P W Q G Q V E P Q L L K T V P R H D P L N P L C P G A I R A N G E V N P Q Y D S T F L F D N D F P A L Q P D A P S P G P S D H P L F Q A K S A R G V C K V M C F H P W S D V T L P L M S V P E I R A V V D A W A S V T E E L G A Q Y P W V Q I F E N K G A M M G C S N P H P H C Q V W A S S F L P D I A Q R E E R S Q Q A Y K S Q H G E P L L M E Y S R Q E L L R K E R L V L T S E H W L V L V P F W A T W P Y Q T L L L P R R H V R R L P E L T P A E R D D L A S I M K K L L T K Y D N L F E T S F P Y S M G W H G A P T G S E A G A N W N H W Q L H A H Y Y P P L L R S A T V R K F M V G Y E M L A Q A Q R D L T P E Q A A E R L R A L P E V H Y H L G Q K D R E T A T I A
- Accession
- P07902
- Protein length
- Full Length
- Predicted molecular weight
- 45.9 kDa
- Amino acids
- 1 to 379
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab139613 is purified using conventional chromatography techniques.
General info
- Function
Plays an important role in galactose metabolism.
- Sequence similarities
Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
GALT also known as galactose-1-phosphate uridyltransferase is an enzyme involved in the Leloir pathway of galactose metabolism. The GALT protein facilitates the conversion of galactose-1-phosphate (Gal-1-P) and UDP-glucose to UDP-galactose and glucose-1-phosphate important steps in the cellular utilization of galactose. This enzyme has a molecular mass of approximately 43 kDa. GALT is expressed in various tissues and is notably present in the liver and erythrocytes where efficient galactose metabolism is essential.
- Biological function summary
GALT plays a role in carbohydrate metabolism by regulating galactose conversion to glucose a principal energy source. It does not form part of a complex but works alongside other enzymes such as galactokinase and UDP-galactose 4'-epimerase in the Leloir pathway. This enzymatic action ensures that galactose from food sources is metabolized properly contributing to overall energy homeostasis within the body.
- Pathways
GALT participates in the Leloir pathway which is essential for the breakdown and utilization of galactose. Through this pathway GALT interacts indirectly with related proteins like galactokinase and UDP-galactose 4'-epimerase. This enzymatic pathway is linked to complex carbohydrate metabolism and feeds into broader glucose metabolism processes underlining its importance in maintaining glucose levels.
- Associated diseases and disorders
GALT is linked to classic galactosemia a rare genetic metabolic disorder. This condition arises from an impairment in the GALT enzyme leading to toxic accumulation of galactose-1-phosphate in the body. Individuals with classic galactosemia often experience symptoms like jaundice liver enlargement and can develop cataracts or mental developmental issues if not treated early. In the context of this disorder proteins such as galactokinase also play a role since they are upstream in the metabolic pathway that leads to the problematic accumulation.
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
SDS-PAGE - Recombinant Human GALT protein (ab139613)
15% SDS-PAGE analysis of ab139613 (3μg).
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com