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AB48712

Recombinant Human gamma Synuclein/SNCG protein (Tag Free)

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(4 Publications)

Recombinant Human gamma Synuclein/SNCG protein (Tag Free) is a Human Full Length protein, in the 1 to 127 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, WB.

View Alternative Names

BCSG1, PERSYN, PRSN, SNCG, Gamma-synuclein, Breast cancer-specific gene 1 protein, Persyn, Synoretin, SR

3 Images
Western blot - Recombinant Human gamma Synuclein/SNCG protein (Tag Free) (AB48712)
  • WB

Project

Western blot - Recombinant Human gamma Synuclein/SNCG protein (Tag Free) (AB48712)

All lanes:

Western blot - Anti-gamma Synuclein/SNCG antibody (<a href='/en-us/products/primary-antibodies/gamma-synuclein-sncg-antibody-ab46201'>ab46201</a>) at 0.5 µg/mL

All lanes:

Western blot - Recombinant Human gamma Synuclein/SNCG protein (Tag Free) (ab48712) at 0.05 µg

Secondary

All lanes:

Goat polyclonal to rabbit IgG - H&L - Pre adsorbed (HRP) at 1/3000 dilution

Predicted band size: 13 kDa

Observed band size: 15 kDa

false

Western blot - Recombinant Human gamma Synuclein/SNCG protein (Tag Free) (AB48712)
  • WB

Project

Western blot - Recombinant Human gamma Synuclein/SNCG protein (Tag Free) (AB48712)

All lanes:

Western blot - Anti-gamma Synuclein/SNCG antibody (<a href='/en-us/products/primary-antibodies/gamma-synuclein-sncg-antibody-ab46201'>ab46201</a>) at 0.5 µg/mL

All lanes:

Western blot - Recombinant Human gamma Synuclein/SNCG protein (Tag Free) (ab48712) at 0.05 µg

Secondary

All lanes:

Goat polyclonal to rabbit IgG - H&L - Pre adsorbed (HRP) at 1/3000 dilution

Predicted band size: 13 kDa

Observed band size: 15 kDa

false

SDS-PAGE - Recombinant Human gamma Synuclein/SNCG protein (Tag Free) (AB48712)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human gamma Synuclein/SNCG protein (Tag Free) (AB48712)

15% SDS-PAGE gel loaded with recombinant gamma Synuclein/SNCG protein.

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

Tag free

Applications

SDS-PAGE, WB

applications

Biologically active

No

Accession

O76070

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.5 Constituents: 0.58% Sodium chloride, 0.316% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p>Real molecular size on SDS-PAGE will be shifted up.</p>" } } }
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Sequence info

[{"sequence":"MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGAKTKENVVQSVTSVAEKTKEQANAVSEAVVSSVNTVATKTVEEAENIAVTSGVVRKEDLRPSAPQQEGVASKEKEEVAEEAQSGGD","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":127,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O76070","tags":[]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Gamma synuclein sometimes referred to as SNCG or gamma-synuclein is a protein with a molecular weight of approximately 13 kDa. It is a member of the synuclein family which also includes alpha and beta synucleins. This protein is highly expressed in the nervous system particularly in the peripheral nervous system and certain regions of the central nervous system. Outside the nervous system gamma synuclein can be found in the retina reproductive tissues and breast tissue among others.
Biological function summary

Gamma synuclein plays a role in modulating neuronal plasticity and may participate in synaptic regulation. It is not known to be a part of a larger protein complex but it interacts with various other proteins influencing neuron differentiation. Although its precise biological functions are not fully characterized studies suggest that gamma synuclein could impact cellular processes like cytoskeletal dynamics and membrane trafficking.

Pathways

The protein gamma synuclein is involved in cellular stress response and neurodegeneration pathways. It is closely related to proteins like alpha synuclein with which it shares structural and functional features. Pathways involving these proteins can influence several processes such as axonal transport and neurotransmitter release. Dysregulation in these pathways often leads to disruptions in cellular homeostasis.

The involvement of gamma synuclein is most notably seen in breast cancer and neurodegenerative diseases such as Alzheimer's disease. Researchers have observed that this protein is overexpressed in various tumors where it might facilitate cancer progression and metastasis. In neurodegeneration interaction with alpha synuclein and tau protein could play a role in the pathogenesis where protein aggregation is a characteristic feature. Understanding its role in these diseases helps in charting possible therapeutic avenues.
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Specifications

Form

Liquid

Additional notes

The protein coding region of ß-Synuclein was amplified by RT-PCR and cloned into an E.coli expression vector. ß-Synuclein was overexpressed in E. coli and purified to apparent homogeneity by taking advantage of the thermosolubility of the protein and by using conventional column chromatography techniques.

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General info

Function

Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity).

Sequence similarities

Belongs to the synuclein family.

Post-translational modifications

Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases.

Subcellular localisation

Cytoskeleton

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Product protocols

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Target data

Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity).
See full target information SNCG
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

NPJ Parkinson's disease 9:161 PubMed38062007

2023

Development and validation of an expanded antibody toolset that captures alpha-synuclein pathological diversity in Lewy body diseases.

Applications

Unspecified application

Species

Unspecified reactive species

Melek Firat Altay,Senthil T Kumar,Johannes Burtscher,Somanath Jagannath,Catherine Strand,Yasuo Miki,Laura Parkkinen,Janice L Holton,Hilal A Lashuel

Neural regeneration research 15:1894-1902 PubMed32246638

2020

Chimera RNA interference knockdown of γ-synuclein in human cortical astrocytes results in mitotic catastrophe.

Applications

WB

Species

Human

Timmy Le,Cynthia L Winham,Fotis Andromidas,Adam C Silver,Evan R Jellison,Aime A Levesque,Andrew O Koob

Neuroscience 410:41-54 PubMed31078687

2019

γ-Synuclein Induces Human Cortical Astrocyte Proliferation and Subsequent BDNF Expression and Release.

Applications

Unspecified application

Species

Unspecified reactive species

Cynthia L Winham,Timmy Le,Evan R Jellison,Adam C Silver,Aime A Levesque,Andrew O Koob

Biochemistry 51:4743-54 PubMed22620680

2012

γ-Synuclein: seeding of α-synuclein aggregation and transmission between cells.

Applications

Unspecified application

Species

Unspecified reactive species

Irina Surgucheva,Victor S Sharov,Andrei Surguchov
View all publications
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