JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB116188

Recombinant Human GAS41 protein

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human GAS41 protein is a Human Full Length protein, in the 1 to 227 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

GAS41, YEATS4, YEATS domain-containing protein 4, Glioma-amplified sequence 41, NuMA-binding protein 1, Gas41, NuBI-1, NuBI1

1 Images
SDS-PAGE - Recombinant Human GAS41 protein (AB116188)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human GAS41 protein (AB116188)

ab116188 (3μg) analysed on a 15% SDS-PAGE gel.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

O95619

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.5 Constituents: 30% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.03% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.002% PMSF

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMFKRMAEFGPDSGGRVKGVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNEDMSAYVKKIQFKLHESYGNPLRVVTKPPYEITETGWGEFEIIIKIFFIDPNERPVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEFAELEVKTREKLEAAKKKTSFEIAELKERLKASRETINCLKNEIRKLEEDDQAKDI","proteinLength":"Full Length","predictedMolecularWeight":"28.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":227,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O95619","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein GAS41 also known as Glioma-Amplified Sequence 41 weighs approximately 26 kDa. It is ubiquitously expressed in various cell types including brain and neuronal tissues. GAS41 performs as a component of the chromatin remodeling complex. This protein participates in DNA binding and potentially regulates transcription processes influencing gene expression patterns.
Biological function summary

GAS41 impacts cellular proliferation and organization. It is often part of the Tip60/NuA4 histone acetyltransferase complex which is involved in chromatin modification. Through its role in this complex GAS41 influences transcriptional regulation by modifying chromatin architecture. This process ultimately affects how genes are turned on or off in cells which is key for maintaining cellular function and identity.

Pathways

GAS41 plays a significant role in the regulation of gene expression pathways and cell cycle control. It interacts with proteins in the SWI/SNF-related chromatin remodeler pathways and modulates how genes involved in cell cycle progression are expressed. GAS41 shows interaction with proteins like p400 which also contributes to these pathways indicating its importance in cellular growth and division.

GAS41 is linked to glioma progression and certain neurodegenerative disorders. Changes in the expression of GAS41 have been observed in gliomas connecting it with the uncontrolled cell growth characteristic of these tumors. Through its association with other proteins like ATRX GAS41 is implicated in chromatin remodeling disturbances seen in neurodegenerative diseases influencing gene expression patterns and contributing to disease pathogenesis.
style
left-column

Specifications

Form

Liquid

Additional notes

ab116188 was purified using conventional chromatography.

style
left-column

General info

Function

Chromatin reader component of the NuA4 histone acetyltransferase (HAT) complex, a complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed : 12963728, PubMed : 14966270). Specifically recognizes and binds acylated histone H3, with a preference for histone H3 diacetylated at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac) or histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac) (PubMed : 29437725, PubMed : 29900004, PubMed : 30071723). Also able to recognize and bind crotonylated histone H3 (PubMed : 30071723). May also recognize and bind histone H3 succinylated at 'Lys-122' (H3K122succ); additional evidences are however required to confirm this result in vivo (PubMed : 29463709). Plays a key role in histone variant H2AZ1/H2A.Z deposition into specific chromatin regions : recognizes and binds H3K14ac and H3K27ac on the promoters of actively transcribed genes and recruits NuA4-related complex to deposit H2AZ1/H2A.Z (PubMed : 29437725). H2AZ1/H2A.Z deposition is required for maintenance of embryonic stem cell (By similarity).

Subcellular localisation

Nucleus

style
left-column

Product protocols

style
left-column

Target data

Chromatin reader component of the NuA4 histone acetyltransferase (HAT) complex, a complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed : 12963728, PubMed : 14966270). Specifically recognizes and binds acylated histone H3, with a preference for histone H3 diacetylated at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac) or histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac) (PubMed : 29437725, PubMed : 29900004, PubMed : 30071723). Also able to recognize and bind crotonylated histone H3 (PubMed : 30071723). May also recognize and bind histone H3 succinylated at 'Lys-122' (H3K122succ); additional evidences are however required to confirm this result in vivo (PubMed : 29463709). Plays a key role in histone variant H2AZ1/H2A.Z deposition into specific chromatin regions : recognizes and binds H3K14ac and H3K27ac on the promoters of actively transcribed genes and recruits NuA4-related complex to deposit H2AZ1/H2A.Z (PubMed : 29437725). H2AZ1/H2A.Z deposition is required for maintenance of embryonic stem cell (By similarity).
See full target information YEATS4
style
left-column
style
left-column
style
right-column

Complementary Products

Proteins & Peptides

AB152790

Recombinant Human FIP protein

SDS-PAGE - Recombinant Human FIP protein (AB152790)

  • 0
  • 0
Primary Antibodies

AB205018

Anti-GAS41 antibody

Western blot - Anti-GAS41 antibody (AB205018)

  • 5
  • 1
Proteins & Peptides

AB95933

Recombinant human XIAP protein

Functional Studies - Recombinant human XIAP protein (AB95933)

  • 0
  • 0
Proteins & Peptides

AB112374

Recombinant Human Tristetraprolin/TTP protein

SDS-PAGE - Recombinant Human Tristetraprolin/TTP protein (AB112374)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com