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AB131669

Recombinant Human Gastrokine 1 protein

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Recombinant Human Gastrokine 1 protein is a Human Full Length protein, in the 1 to 199 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

AMP18, CA11, UNQ489/PRO1005, GKN1, Gastrokine-1, 18 kDa antrum mucosa protein, Protein CA11, AMP-18

1 Images
SDS-PAGE - Recombinant Human Gastrokine 1 protein (AB131669)
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SDS-PAGE - Recombinant Human Gastrokine 1 protein (AB131669)

15% SDS-PAGE showing ab131669 at approximately 24.5 kDa (3μg).

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q9NS71

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMLAYSSVHCFREDKMKFTIVFAGLLGVFLAPALANYNINVNDDNNNAGSGQQSVSVNNEHNVANVDNNNGWDSWNSIWDYGNGFAATRLFQKKTCIVHKMNKEVMPSIQSLDALVKEKKLQGKGPGGPPPKGLMYSVNPNKVDDLSKFGKNIANMCRGIPTYMAEEMQEASLFFYSGTCYTTSVLWIVDISFCGDTVEN","proteinLength":"Full Length","predictedMolecularWeight":"24.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":199,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NS71","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Gastrokine 1 also known as GKN1 is a protein with a molecular weight of approximately 18 kDa. It is expressed mainly in the gastric epithelium. This protein plays a mechanical role in maintaining gastric mucosal integrity. It has been associated with epithelial cell differentiation and proliferation a process important for stomach lining health. Gastrokine 1 interacts with other cellular components to stabilize and repair the gastric mucosa following injury or stress.
Biological function summary

This protein supports gastric mucosal defense mechanisms. It participates in maintaining the epithelial barrier against harmful digestive enzymes and pathogens. Gastrokine 1 is not part of a larger protein complex but operates independently to influence mucosal protection. Its ability to modulate cell turnover and repair processes highlights its importance in sustaining gastric homeostasis.

Pathways

Gastrokine 1 functions within the gastric mucosal protective pathway. It often relates to the signaling pathways involving epidermal growth factor receptor (EGFR) and inflammation mediation. The absence or reduction of GKN1 can disrupt these pathways impacting other proteins such as MUC5AC which also contribute to the protective mucosal barrier. The interaction between these proteins ensures a coordinated response in maintaining the stomach lining integrity.

Alterations in Gastrokine 1 expression have associations with gastric cancer and gastritis. Reduced levels of this protein often correspond with increased gastric epithelial damage and carcinogenesis risks. GKN1's association with diseases like gastric cancer makes it a potential biomarker. Additionally its interaction with Helicobacter pylori a bacterium linked to chronic gastritis and cancer demonstrates the protein's critical role in disease prevention.
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Specifications

Form

Liquid

Additional notes

Purified using conventional chromatography techniques.

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General info

Function

Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.

Sequence similarities

Belongs to the gastrokine family.

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Product protocols

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Target data

Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.
See full target information GKN1
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Complementary Products

Primary Antibodies

AB203094

Anti-Gastrokine 1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Gastrokine 1 antibody (AB203094)

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