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AB134866

Recombinant Human GATA2 protein

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(1 Publication)

Recombinant Human GATA2 protein is a Human Full Length protein, in the 2 to 480 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

Endothelial transcription factor GATA-2, GATA-binding protein 2, GATA2

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

Tag free

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P23769

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: Glycerol (glycerin, glycerine), Potassium chloride, Sodium chloride, 3.4% DL-Arginine, 0.32% Tris HCl, 0.05% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.02% EDTA

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"(29 amino acid tag)EVAPEQPRWMAHPAVLNAQHPDSHHPGLAHNYMEPAQLLPPDEVDVFFNHLDSQGNPYYANPAHARARVSYSPAHARLTGGQMCRPHLLHSPGLPWLDGGKAALSAAAAHHHNPWTVSPFSKTPLHPSAAGGPGGPLSVYPGAGGGSGGGSGSSVASLTPTAAHSGSHLFGFPPTPPKEVSPDPSTTGAASPASSSAGGSAARGEDKDGVKYQVSLTESMKMESGSPLRPGLATMGTQPATHHPIPTYPSYVPAAAHDYSSGLFHPGGFLGGPASSFTPKQRSKARSCSEGRECVNCGATATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSNKSKKSKKGAECFEELSKCMQEKSSPFSAAALAGHMAPVGHLPPFSHSGHILPTPTPIHPSSSLSFGHPHPSSMVTAMGLEESGGGGSPGRRRRRRRRRRR","proteinLength":"Full Length","predictedMolecularWeight":"50.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":480,"aminoAcidStart":2,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P23769","tags":[]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GATA2 also known as GATA binding protein 2 is a transcription factor with a molecular mass of approximately 50 kDa. It plays an important mechanical role in regulating gene expression by binding to the DNA sequence "GATA". GATA2 is expressed in various tissues including hematopoietic cells the nervous system and the endothelium. It influences cell fate decisions impacting the development and function of multiple tissues and cell types.
Biological function summary

GATA2 governs hematopoiesis and vascular development. It operates within multiprotein complexes to control the transcription of genes necessary for the development and differentiation of hematopoietic stem cells. GATA2's presence aids in maintaining normal functions of these cells ensuring they proliferate and differentiate correctly. Its regulatory role extends to the vascular system where GATA2 controls endothelial cell function and blood vessel formation.

Pathways

Hematopoiesis and vascular development significantly involve GATA2. It participates in the Notch signaling pathway influencing cell differentiation and proliferation along with other transcription factors like GATA1 and FOG1. The pathway interplay facilitates normal blood cell production and proper vascularization emphasizing its important role in cellular development processes.

Defective GATA2 function links to immunodeficiency syndromes and acute myeloid leukemia (AML). Mutations in the GATA2 gene disrupt normal blood cell development often resulting in increased susceptibility to infections and hematologic malignancies. It interacts with proteins such as GATA1 in these pathological states highlighting its significance in both immune function and malignant transformation.
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Specifications

Form

Liquid

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General info

Function

Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.
See full target information GATA2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 13:3145 PubMed35672415

2022

Dynamic nucleosome landscape elicits a noncanonical GATA2 pioneer model.

Applications

Unspecified application

Species

Unspecified reactive species

Tianbao Li,Qi Liu,Zhong Chen,Kun Fang,Furong Huang,Xueqi Fu,Qianben Wang,Victor X Jin
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