Recombinant Human GCET2 protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GCET2 also known as germinal center-expressed transcript 2 or centroblast protein has a molecular mass of approximately 19 kDa. It expresses mainly in germinal center B cells specifically the centroblasts within lymphoid tissues. This protein functions mechanically by having a role in the regulation of B cell differentiation and proliferation. Research demonstrates its expression during specific stages of B cell development indicating an important involvement during immune processes.

Biological function summary

This protein influences the immune response by contributing to the maturation and selection of B cells within germinal centers. Although not known to be a part of any larger complex its expression corresponds with stages critical to adaptive immunity. GCET2 supports the processes that ensure only high-affinity B cell receptors mature fostering a strong and specific immune defense.

Pathways

Researchers place GCET2 in connection with the germinal center reaction a significant pathway in adaptive immunity. This pathway involves interaction with proteins such as Bcl-6 which regulates the formation and maintenance of germinal centers. Another pathway is the somatic hypermutation process critical for antibody diversity where GCET2 may influence the changes in antibody affinity.

Scientists have linked GCET2 to certain conditions like lymphoma where its dysregulated expression may contribute to tumorigenesis. Evidence suggests that abnormalities in GCET2 expression levels correlate with the progression of some lymphoid malignancies. In autoimmune disorders this protein has associations with aberrant immune responses potentially increasing susceptibility to conditions characterized by excessive or uncontrolled immune activity.