Recombinant Human GDF11 protein (denatured) (His tag N-Terminus)
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Recombinant Human GDF11 protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 299 to 407 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.
View Alternative Names
BMP11, GDF11, Growth/differentiation factor 11, GDF-11, Bone morphogenetic protein 11, BMP-11
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human GDF11 protein (denatured) (His tag N-Terminus) (AB202626)
15% SDS-PAGE analysis of ab202626 (3μg).
Reactivity data
Product details
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Specifications
Form
Liquid
Additional notes
ab202626 was purified by conventional chromatography techniques.
General info
Function
Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues (By similarity). It is required for proper vertebral patterning and orofacial development (PubMed : 31215115). Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 (PubMed : 28257634).
Sequence similarities
Belongs to the TGF-beta family.
Post-translational modifications
Synthesized as large precursor molecule that undergoes proteolytic cleavage by furin-like proteases (PubMed:31215115). This produces an inactive form consisting of the mature C-terminal portion non-covalently bound to its cleaved N-terminal propeptide. Activation of the mature form requires additional cleavage of the propeptide by a tolloid-like metalloproteinase.
Target data
Complementary Products
Product promise
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