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AB50097

Recombinant human GDF8 / Myostatin protein

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Recombinant human GDF8 / Myostatin protein is a Human Fragment protein, in the 267 to 375 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, FuncS (Neut/Block), FuncS.

View Alternative Names

GDF8, MSTN, Growth/differentiation factor 8, GDF-8, Myostatin

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

Tag free

Applications

FuncS (Neut/Block), FuncS, SDS-PAGE

applications

Biologically active

Yes

Biological activity

Determined by its ability to inhibit the proliferation of MPC-11 cells. The expected ED50 for this effect is 17.0-25.0 ng/ml.

Accession

O14793

Animal free

No

Carrier free

No

Species

Human

Reconstitution

Reconstitute in water

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Complementary Products

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AB218103

Recombinant human GDF11 protein (Animal Free)

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Functional Studies - Recombinant human GDF11 protein (Animal Free) (AB218103)

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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AB259381

Recombinant human IL-6 protein (Active)

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Primary Antibodies

AB203076

Anti-GDF8 / Myostatin antibody

Western blot - Anti-GDF8 / Myostatin antibody (AB203076)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS (Neut/Block)": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p>The inhibition of the proliferation of MPC-11 cells. The expected ED50 for this effect is 17.0-25.0 ng/ml.</p>" } } }
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Sequence info

[{"linker":null,"sequence":"DFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS","proteinLength":"Fragment","predictedMolecularWeight":"25 kDa","actualMolecularWeight":null,"aminoAcidEnd":375,"aminoAcidStart":267,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O14793","tags":[]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
True
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Specifications

Form

Lyophilized

Additional notes

Greater than 98% by SDS-PAGE and HPLC analyses.

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General info

Function

Acts specifically as a negative regulator of skeletal muscle growth.

Sequence similarities

Belongs to the TGF-beta family.

Post-translational modifications

Synthesized as large precursor molecule that undergoes proteolytic cleavage to generate an N-terminal propeptide and a disulfide linked C-terminal dimer, which is the biologically active molecule. The circulating form consists of a latent complex of the C-terminal dimer and other proteins, including its propeptide, which maintain the C-terminal dimer in a latent, inactive state. Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase.

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Product protocols

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Target data

Acts specifically as a negative regulator of skeletal muscle growth.
See full target information MSTN
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Product promise

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