Recombinant human GDF8 / Myostatin protein (Active)
- Bioactive
- What is this?
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(1 Publication)
Recombinant human GDF8 / Myostatin protein (Active) is a Human Full Length protein, in the 267 to 375 aa range, expressed in Escherichia coli, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS.
View Alternative Names
GDF8, MSTN, Growth/differentiation factor 8, GDF-8, Myostatin
- FuncS
Unknown
Functional Studies - Recombinant human GDF8 / Myostatin protein (Active) (AB269163)
Biological activity graph of ab269163
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant human GDF8 / Myostatin protein (Active) (AB269163)
SDS-PAGE analysis of ab269163 at 1ug/lane under (-) non-reducing and (+) reducing conditions. 4-20% Tris glycine gel. Stained with coomassie blue.
Complementary Products
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Specifications
Form
Lyophilized
Additional notes
nan
General info
Function
Acts specifically as a negative regulator of skeletal muscle growth.
Sequence similarities
Belongs to the TGF-beta family.
Post-translational modifications
Synthesized as large precursor molecule that undergoes proteolytic cleavage to generate an N-terminal propeptide and a disulfide linked C-terminal dimer, which is the biologically active molecule. The circulating form consists of a latent complex of the C-terminal dimer and other proteins, including its propeptide, which maintain the C-terminal dimer in a latent, inactive state. Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase.
Target data
Publications (1)
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Nature communications 16:5976 PubMed40593645
2025
Applications
Unspecified application
Species
Unspecified reactive species
Product promise
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