Recombinant human GDF8 / Myostatin protein (Animal Free)
- Bioactive
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(1 Publication)
Recombinant human GDF8 / Myostatin protein (Animal Free) is a Human Full Length protein, in the 267 to 375 aa range, expressed in Escherichia coli, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS.
View Alternative Names
GDF8, MSTN, Growth/differentiation factor 8, GDF-8, Myostatin
- FuncS
Supplier Data
Functional Studies - Recombinant human GDF8 / Myostatin protein (Animal Free) (AB256090)
Functional analysis of ab256090.
- PepArr
Supplier Data
Peptide Array - Recombinant human GDF8 / Myostatin protein (Animal Free) (AB256090)
SDS-PAGE analysis of ab256090 (1 μg) under non-reducing (Lane 1) and reducing (Lane 2) conditions. ab256090 is a homodimer with a predicted MW of 24.8 kDa (monomer size is 12.4 kDa).
4-20% Tris-Glycine gel. Coomassie Blue staining.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Specifications
Form
Lyophilized
General info
Function
Acts specifically as a negative regulator of skeletal muscle growth.
Sequence similarities
Belongs to the TGF-beta family.
Post-translational modifications
Synthesized as large precursor molecule that undergoes proteolytic cleavage to generate an N-terminal propeptide and a disulfide linked C-terminal dimer, which is the biologically active molecule. The circulating form consists of a latent complex of the C-terminal dimer and other proteins, including its propeptide, which maintain the C-terminal dimer in a latent, inactive state. Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase.
Target data
Publications (1)
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Nature communications 16:5976 PubMed40593645
2025
Applications
Unspecified application
Species
Unspecified reactive species
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