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AB313695

Recombinant Human GDNF Protein

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Recombinant Human GDNF Protein is a Human Full Length protein, in the 78 to 211 aa range, expressed in HEK 293 cells, with >0.95%, <0.005 EU/µg endotoxin level, suitable for Mass Spec, HPLC, SDS-PAGE.

View Alternative Names

Glial cell line-derived neurotrophic factor, hGDNF, Astrocyte-derived trophic factor, ATF, GDNF

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Mass Spectrometry - Recombinant Human GDNF Protein (AB313695)
  • Mass Spec

Lab

Mass Spectrometry - Recombinant Human GDNF Protein (AB313695)

Mass determination by ESI-TOF. Predicted MW is 15125.37 (+/- 10Da by ESI-TOF). Observed MW is 15126.55.

SDS-PAGE - Recombinant Human GDNF Protein (AB313695)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human GDNF Protein (AB313695)

SDS-page analysis of ab313695

HPLC - Recombinant Human GDNF Protein (AB313695)
  • HPLC

Lab

HPLC - Recombinant Human GDNF Protein (AB313695)

HPLC analysis of ab313695

Key facts

Purity

>0.95% HPLC

Endotoxin level

<0.005 EU/µg

Expression system

HEK 293 cells

Tags

Tag free

Applications

SDS-PAGE, HPLC, Mass Spec

applications

Biologically active

No

Accession

P39905

Animal free

Yes

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 10.26% Trehalose, 0.727% Dibasic monohydrogen potassium phosphate, 0.248% Potassium phosphate monobasic

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Secondary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"linker":null,"sequence":"SPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKVGQACCRPIAFDDDLSFLDDNLVYHILRKHSAKRCGCI","proteinLength":"Full Length","predictedMolecularWeight":"15.1 kDa","actualMolecularWeight":"15.1 kDa","aminoAcidEnd":211,"aminoAcidStart":78,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"P39905","tags":[]}]
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Properties and storage information

Form
Lyophilized
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
False
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General info

Function

Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake (PubMed : 8493557). Acts by binding to its coreceptor, GFRA1, leading to autophosphorylation and activation of the RET receptor (PubMed : 10829012, PubMed : 25242331, PubMed : 31535977). Involved in the development of the neural crest (PubMed : 15242795).

Sequence similarities

Belongs to the TGF-beta family. GDNF subfamily.

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Product protocols

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Target data

Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake (PubMed : 8493557). Acts by binding to its coreceptor, GFRA1, leading to autophosphorylation and activation of the RET receptor (PubMed : 10829012, PubMed : 25242331, PubMed : 31535977). Involved in the development of the neural crest (PubMed : 15242795).
See full target information GDNF
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Product promise

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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