Recombinant Human GDNF Protein is a Human Full Length protein, in the 78 to 211 aa range, expressed in HEK 293, with >=0.95% purity, <= 0.005 EU/µg endotoxin level and suitable for MS, HPLC, SDS-PAGE.
Images
Key facts
- Purity
- >=0.95% HPLC
- Endotoxin level
- <= 0.005 EU/µg
- Expression system
- HEK 293 cells
- Tags
- Tag free
- Applications
- MS, HPLC, SDS-PAGE
- Biologically active
- No
Amino acid sequence
S P D K Q M A V L P R R E R N R Q A A A A N P E N S R G K G R R G Q R G K N R G C V L T A I H L N V T D L G L G Y E T K E E L I F R Y C S G S C D A A E T T Y D K I L K N L S R N R R L V S D K V G Q A C C R P I A F D D D L S F L D D N L V Y H I L R K H S A K R C G C I
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Application HPLC | Reactivity Reacts | Dilution info - | Notes - |
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake (PubMed:8493557). Acts by binding to its coreceptor, GFRA1, leading to autophosphorylation and activation of the RET receptor (PubMed:10829012, PubMed:25242331, PubMed:31535977). Involved in the development of the neural crest (PubMed:15242795).
Alternative names
Glial cell line-derived neurotrophic factor, hGDNF, Astrocyte-derived trophic factor, ATF, GDNF
Recommended products
Recombinant Human GDNF Protein is a Human Full Length protein, in the 78 to 211 aa range, expressed in HEK 293, with >=0.95% purity, <= 0.005 EU/µg endotoxin level and suitable for MS, HPLC, SDS-PAGE.
Key facts
- Purity
- >=0.95% HPLC
- Endotoxin level
- <= 0.005 EU/µg
- Expression system
- HEK 293 cells
- Tags
- Tag free
- Applications
- MS, HPLC, SDS-PAGE
- Biologically active
- No
- Accession
- P39905-1
- Animal free
- Yes
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 10.26% Trehalose, 0.727% Dibasic monohydrogen potassium phosphate, 0.248% Potassium phosphate monobasic
Sequence info
Amino acid sequence
- S P D K Q M A V L P R R E R N R Q A A A A N P E N S R G K G R R G Q R G K N R G C V L T A I H L N V T D L G L G Y E T K E E L I F R Y C S G S C D A A E T T Y D K I L K N L S R N R R L V S D K V G Q A C C R P I A F D D D L S F L D D N L V Y H I L R K H S A K R C G C I
- Accession
- P39905
- Protein length
- Full Length
- Predicted molecular weight
- 15.1 kDa
- Actual molecular weight
- 15.1 kDa
- Amino acids
- 78 to 211
- Nature
- Recombinant
Specifications
- Form
- Lyophilized
General info
- Function
Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake (PubMed:8493557). Acts by binding to its coreceptor, GFRA1, leading to autophosphorylation and activation of the RET receptor (PubMed:10829012, PubMed:25242331, PubMed:31535977). Involved in the development of the neural crest (PubMed:15242795).
- Sequence similarities
Belongs to the TGF-beta family. GDNF subfamily.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- Ambient
- Appropriate long-term storage conditions
- Ambient
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
3 product images
SDS-PAGE - Recombinant Human GDNF Protein (ab313695)
SDS-page analysis of ab313695
Mass Spectrometry - Recombinant Human GDNF Protein (ab313695)
Mass determination by ESI-TOF. Predicted MW is 15125.37 (+/- 10Da by ESI-TOF). Observed MW is 15126.55.
HPLC - Recombinant Human GDNF Protein (ab313695)
HPLC analysis of ab313695
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com