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AB276249

Recombinant Human GDNF Receptor alpha 2/GFRA2 protein (His tag)

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Recombinant Human GDNF Receptor alpha 2/GFRA2 protein (His tag) is a Human Fragment protein, in the 1 to 441 aa range, expressed in HEK 293 cells, with >98%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

GDNFRB, RETL2, TRNR2, GFRA2, GDNF family receptor alpha-2, GDNF receptor alpha-2, GDNFR-alpha-2, GFR-alpha-2, GDNF receptor beta, Neurturin receptor alpha, RET ligand 2, TGF-beta-related neurotrophic factor receptor 2, GDNFR-beta, NRTNR-alpha, NTNR-alpha

1 Images
SDS-PAGE - Recombinant Human GDNF Receptor alpha 2/GFRA2 protein (His tag) (AB276249)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human GDNF Receptor alpha 2/GFRA2 protein (His tag) (AB276249)

SDS-PAGE analysis of ab276249

Key facts

Purity

>98% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

O00451

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.5 Constituents: 100% PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MILANVFCLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTLRQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEFYEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCSYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGMIGFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTDVNVSPKGPSFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKELSMCFTELTTNIIPGSNKVIKPNS","proteinLength":"Fragment","predictedMolecularWeight":"48.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":441,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"O00451","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Specifications

Form

Lyophilized

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General info

Function

Receptor for neurturin (NRTN), a growth factor that supports the survival of sympathetic neurons (PubMed : 10829012, PubMed : 29414779, PubMed : 31535977, PubMed : 9182803). NRTN-binding leads to autophosphorylation and activation of the RET receptor (PubMed : 31535977). Also able to mediate GDNF signaling through the RET tyrosine kinase receptor (PubMed : 9182803).. Isoform 2. Participates in NRTN-induced 'Ser-727' phosphorylation of STAT3.

Sequence similarities

Belongs to the GDNFR family.

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Product protocols

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Target data

Receptor for neurturin (NRTN), a growth factor that supports the survival of sympathetic neurons (PubMed : 10829012, PubMed : 29414779, PubMed : 31535977, PubMed : 9182803). NRTN-binding leads to autophosphorylation and activation of the RET receptor (PubMed : 31535977). Also able to mediate GDNF signaling through the RET tyrosine kinase receptor (PubMed : 9182803).. Isoform 2. Participates in NRTN-induced 'Ser-727' phosphorylation of STAT3.
See full target information GFRA2
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Primary Antibodies

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