Recombinant Human GIMAP5 protein (His tag N-Terminus)
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Recombinant Human GIMAP5 protein (His tag N-Terminus) is a Human Fragment protein, in the 1 to 284 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
IAN4L1, IAN5, IMAP3, GIMAP5, GTPase IMAP family member 5, Immune-associated nucleotide-binding protein 5, Immunity-associated nucleotide 4-like 1 protein, Immunity-associated nucleotide 5 protein, Immunity-associated protein 3, IAN-5, hIAN5
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human GIMAP5 protein (His tag N-Terminus) (AB171714)
15% SDS-PAGE analysis of ab171714 (3μg).
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
GIMAP5 plays an important role in lymphocyte survival by preventing apoptosis which is important for an effective immune response. GIMAP5 is essential for the development and function of regulatory T cells which are vital for maintaining immune tolerance. It is not typically part of a large protein complex but it interfaces with several key proteins on the mitochondrial membrane. Its role in immunity suggests a protective mechanism against excessive immune activation.
Pathways
The role of GIMAP5 is central in immune regulation pathways like the T-cell activation pathway. It influences the IL-7 signaling pathway which is significant for T cell development and survival. GIMAP5 functions in conjunction with other proteins such as Bcl-2 a well-known protein that regulates cell death providing support to lymphocyte longevity and function during immune responses.
Specifications
Form
Liquid
Additional notes
ab171714 was purified by using conventional chromatography techniques.
General info
Function
Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation (PubMed : 29382851). Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). May promote the survival of mature T lymphocytes upon cytokine withdrawal (By similarity). May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation (By similarity). May play a role in mitochondrial DNA segregation in hematopoietic tissues (By similarity). Is a regulator of liver endothelial cell homeostasis (By similarity).
Sequence similarities
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.
Subcellular localisation
Lysosome membrane
Target data
Complementary Products
Product promise
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