JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB167915

Recombinant Human GIMAP6 protein (His tag N-Terminus)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human GIMAP6 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 292 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

IAN2, IAN6, GIMAP6, GTPase IMAP family member 6, Immunity-associated nucleotide 2 protein, Immunity-associated nucleotide 6 protein, IAN-2, hIAN2, IAN-6, hIAN6

1 Images
SDS-PAGE - Recombinant Human GIMAP6 protein (His tag N-Terminus) (AB167915)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human GIMAP6 protein (His tag N-Terminus) (AB167915)

15% SDS-PAGE analysis of 3 μg ab167915

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q6P9H5

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 30% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMEEEEYEQIPQENPPEELSQDPVLELSGGLREKEQKTPRRLRLILMGKTGSGKSATGNSILGRDVFESKLSTRPVTKTSQRRSREWAGKELEVIDTPNILSPQVSPEVADAICQAIVLSAPGPHAVLLVTQLGRFTDEDQQVVRRLQEVFGVGVLGHTILVFTRKEDLAGGSLEDYVRETNNQALAWLDVTLARRHCGFNNRAQGEEQEAQLRELMEKVEAIMWENEGDYYSNKAYQYTQQNFRLKELQERQVSQGQGSEDVPGEESWLEGLSQIQKESEEAHRCLLGKADL","proteinLength":"Full Length","predictedMolecularWeight":"35 kDa","actualMolecularWeight":null,"aminoAcidEnd":292,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q6P9H5","tags":[{"tag":"His","terminus":"N-Terminus"}]}]

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GIMAP6 also known as GTPase IMAP family member 6 plays a significant role in cellular mechanisms. It is a small GTPase with a molecular mass of approximately 33 kDa. GIMAP6 is highly expressed in immune-related tissues particularly in lymphoid organs such as the spleen and lymph nodes. Unlike some proteins with widespread expression the presence of GIMAP6 seems more restricted to specific immune cells indicating its specialized functions in the immune system.
Biological function summary

The functions involving GTPase such as GIMAP6 regulate immune cell survival and homeostasis. It participates in critical cellular processes like apoptosis and autophagy often interacting with other members of the GIMAP family. GIMAP6 involvement suggests its integration in protein complexes that maintain cellular balance and response to stressors. Due to these activities GIMAP6 helps to modulate cell fate decisions in lymphocytes and perhaps other immune cells.

Pathways

Knowledge about GIMAP6 connects it to the regulation of autophagy and apoptosis pathways. It possibly interacts with molecules like Beclin-1 which plays a central role in the autophagy pathway. These interactions imply a connection to the PI3K/Akt signaling pathway where GIMAP proteins can influence survival signals and cellular responses. Therefore GIMAP6 has the potential to intersect with pathways involving other GTPase family proteins highlighting its influence within immune signaling networks.

Research links GIMAP6 with autoimmune diseases and certain types of lymphoproliferative disorders. Variations in GIMAP6 expression or activity can contribute to immune dysregulation observed in these conditions. Furthermore GIMAP6 relationships with proteins like Bcl-2 known for roles in apoptosis regulation highlight its importance in diseases where cell survival and death mechanisms are disrupted. The understanding of GIMAP6 in these contexts might offer insights into novel therapeutic approaches for immune-related conditions.

Specifications

Form

Liquid

Additional notes

purified by using conventional chromatography techniques.

General info

Sequence similarities

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

Product protocols

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com