Recombinant Human GIPR protein (Tagged)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The gastric inhibitory polypeptide receptor (GIPR) sometimes called glucose-dependent insulinotropic polypeptide receptor is a member of the class B1 family of G-protein-coupled receptors. GIPR weighs approximately 52 kDa and is widely expressed in pancreatic beta-cells adipose tissue and the central nervous system. It binds to its ligand the gastric inhibitory polypeptide (GIP) which is critical for its functional activities.

Biological function summary

Without directly naming GIPR it plays significant roles in glucose homeostasis and lipid metabolism. GIPR is not part of a larger protein complex but binds to GIP to initiate signaling pathways that stimulate insulin secretion. This receptor-ligand interaction is essential in regulating postprandial (after meals) insulin release influencing glucose and fat utilization and storage in the body.

Pathways

GIPR participates critically in the incretin signaling pathway. It associates with other incretin receptors like the glucagon-like peptide-1 receptor (GLP-1R) which collectively enhance glucose-induced insulin release. Within the glucose-regulatory network GIPR's interaction with these pathways highlights its role in managing energy balance and promoting beta-cell function.

With reference to obesity and type 2 diabetes GIPR has a substantial impact. Disruptions in GIPR signaling have been linked to impaired insulin secretion and glucose intolerance contributing to these metabolic disorders. Researchers also explore potential connections between GIPR and other proteins like insulin receptor substrate proteins in these conditions as these interactions are critical in understanding the receptor's role in metabolic dysregulation.