Recombinant Human GJB2 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

GJB2 forms channels allowing ions and small molecules to pass between cells enabling direct cell communication. This protein plays a critical role in maintaining homeostasis within tissues by mediating the transfer of signaling molecules like calcium ions and cyclic AMP. GJB2 works together with other connexins to form gap junction channels contributing to the regulation within complex tissue structures. Its role is significant in the auditory system where it facilitates the recycling of potassium ions necessary for converting sound waves into electrical signals.

Pathways

GJB2 interacts prominently in pathways related to cellular communication and signal transduction. The gap junction network that GJB2 participates in is important for hearing involving a cascade of intercellular ionic and metabolic cooperation. Within these pathways GJB2 is functionally related to other connexin proteins like Connexin 30 which often co-localizes in the cochlea to ensure auditory function. This interconnectedness helps maintain the proper function of various epithelial tissues involved in different physiological processes.