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AB114815

Recombinant Human GLEPP1/PTPRO protein

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Recombinant Human GLEPP1/PTPRO protein is a Human Full Length protein, in the 1 to 598 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

GLEPP1, PTPU2, PTPRO, Receptor-type tyrosine-protein phosphatase O, R-PTP-O, Glomerular epithelial protein 1, Protein tyrosine phosphatase U2, PTP-U2, PTPase U2

1 Images
SDS-PAGE - Recombinant Human GLEPP1/PTPRO protein (AB114815)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human GLEPP1/PTPRO protein (AB114815)

12.5% SDS-PAGE Stained with Coomassie Blue

Key facts

Expression system

Wheat germ

Tags

Tag free

Applications

WB, SDS-PAGE, ELISA

applications

Biologically active

No

Accession

Q16827

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.3% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p>Recombinant protein</p>" } } }
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Product details

This product was previously labelled as GLEPP1.
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Sequence info

[{"sequence":"MGHLPTGIHGARRLLPLLWLFVLFKNATAFHVTVQDDNNIVVSLEASDVISPASVYVVKITGESKNYFFEFEEFNSTLPPPVIFKASYHGLYYIITLVVVNGNVVTKPSRSITVLTKPLPVTSVSIYDYKPSPETGVLFEIHYPEKYNVFTRVNISYWEGKDFRTMLYKDFFKGKTVFNHWLPGMCYSNITFQLVSEATFNKSTLVEYSGVSHEPKQHRTAPYPPQNISVRIVNLNKNNWEEQSGNFPEESFMRSQDTIGKEKLFHFTEETPEIPSGNISSGWPDFNSSDYETTSQPYWWDSASAAPESEDEFVSVLPMEYENNSTLSETEKSTSGSFSFFPVQMILTWLPPKPPTAFDGFHIHIEREENFTEYLMVDEEAHEFVAELKEPGKYKLSVTTFSSSGSCETRKSQSAKSLSFYISPSGEWIEELTEKPQHVSVHVLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSKPIIENLVPGAQYQVVIYLRKGPLIGPPSDPVTFAIVPTGIKDLMLYPLGPTAVVLSWTRPYLGVFRKYVVEMFYFNPATMTSEWTTYYEIAATVSLTASVVIFP","proteinLength":"Full Length","predictedMolecularWeight":"91.78 kDa","actualMolecularWeight":null,"aminoAcidEnd":598,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q16827","tags":[]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GLEPP1/PTPRO also known as protein tyrosine phosphatase receptor type O is a receptor-type protein tyrosine phosphatase with a mass around 155 kDa. It is mainly expressed in epithelial cells like podocytes in the kidney glomerulus neurons in the brain and other tissues like liver and lung. GLEPP1/PTPRO catalyzes the removal of phosphate groups from tyrosine residues on proteins an action important for regulating protein function and signal transduction. In podocytes its activity helps maintain the filtration barrier of the kidney.
Biological function summary

GLEPP1/PTPRO participates in cellular growth differentiation and apoptosis. It forms part of the podocyte slit diaphragm complex important for maintaining the glomerular filtration function in kidneys. This protein also interacts with other cellular proteins to regulate signaling pathways that control cellular architecture. Its enzymatic activity influences cellular processes by altering the phosphorylation status of partner proteins.

Pathways

GLEPP1/PTPRO plays essential roles in the MAPK and JAK/STAT signaling pathways. Through these pathways the protein mediates cellular responses to external signals influencing processes like cell cycle progression and survival. It interacts with proteins like Jak2 in these pathways modulating their activities to maintain cellular homeostasis. This involvement emphasizes its importance in signaling impacting cellular responses to environmental changes.

GLEPP1/PTPRO is linked to kidney diseases such as focal segmental glomerulosclerosis (FSGS) and certain cancers. Its dysregulation can lead to abnormal podocyte function contributing to glomerular disease. Moreover in cancer alterations in its activity might affect cancer cell behavior promoting tumor progression. The relation of GLEPP1/PTPRO with proteins like nephrin highlights its contribution to maintaining healthy kidney function and its potential role in disease mechanisms.
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Specifications

Form

Liquid

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General info

Function

Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function (By similarity).

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.

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Product protocols

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Target data

Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function (By similarity).
See full target information PTPRO
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