Recombinant Human GLOD4 protein is a Human Full Length protein, in the 1 to 298 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.
Images
Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M A A R R A L H F V F K V G N R F Q T A R F Y R D V L G M K V L R H E E F E E G C K A A C N G P Y D G K W S K T M V G F G P E D D H F V A E L T Y N Y G V G D Y K L G N D F M G I T L A S S Q A V S N A R K L E W P L T E V A E G V F E T E A P G G Y K F Y L Q N R S L P Q S D P V L K V T L A V S D L Q K S L N Y W C N L L G M K I Y E K D E E K Q R A L L G Y A D N Q C K L E L Q G V K G G V D H A A A F G R I A F S C P Q K E L P D L E D L M K R E N Q K I L T P L V S L D T P G K A T V Q V V I L A D P D G H E I C F V G D E A F R E L S K M D P E G S K L L D D A M A A D K S D E W F A K H N K P K A S G
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Alternative names
C17orf25, CGI-150, My027, GLOD4, Glyoxalase domain-containing protein 4
Recommended products
Recombinant Human GLOD4 protein is a Human Full Length protein, in the 1 to 298 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- Q9HC38-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 20% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.058% Sodium chloride, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M A A R R A L H F V F K V G N R F Q T A R F Y R D V L G M K V L R H E E F E E G C K A A C N G P Y D G K W S K T M V G F G P E D D H F V A E L T Y N Y G V G D Y K L G N D F M G I T L A S S Q A V S N A R K L E W P L T E V A E G V F E T E A P G G Y K F Y L Q N R S L P Q S D P V L K V T L A V S D L Q K S L N Y W C N L L G M K I Y E K D E E K Q R A L L G Y A D N Q C K L E L Q G V K G G V D H A A A F G R I A F S C P Q K E L P D L E D L M K R E N Q K I L T P L V S L D T P G K A T V Q V V I L A D P D G H E I C F V G D E A F R E L S K M D P E G S K L L D D A M A A D K S D E W F A K H N K P K A S G
- Accession
- Q9HC38
- Protein length
- Full Length
- Predicted molecular weight
- 35.3 kDa
- Amino acids
- 1 to 298
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab109939 was purified using conventional chromatography.
General info
- Sequence similarities
Belongs to the glyoxalase I family.
- Subcellular localisation
- Mitochondrion
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
GLOD4 also known as Glyoxalase Domain Containing 4 is a protein with a significant role in cellular processes. It has a molecular mass of approximately 18 kDa. This protein expresses mainly in the liver brain and kidneys indicating its involvement in multiple organ systems. GLOD4 contains characteristic glyoxalase domains which facilitate its biochemical actions. Studies suggest that GLOD4 structurally participates in stress response and detoxification pathways due to these domain properties.
- Biological function summary
Glyoxalase Domain Containing 4 plays important roles in the detoxification of methylglyoxal a byproduct of glycolysis that can be harmful at high levels. GLOD4 does not function alone; it acts as part of the glyoxalase system which includes other Gly and Gly-related enzymes to efficiently convert toxic metabolites into non-toxic substances. Its enzymatic actions support the maintenance of cellular homeostasis and protection against glycation end-products that are damaging to cellular structures.
- Pathways
Glyoxalase Domain Containing 4 operates within key metabolic routes like the glycolytic pathway and the detoxification pathway. It collaborates with enzymes like Glyoxalase I and Glyoxalase II in the aforementioned glyoxalase system to perform its roles. The action within these pathways helps reduce oxidative stress aiding in the prevention of cellular damage. GLOD4’s interaction with these enzymes and pathways highlights its importance in maintaining cellular integrity under physiological and stress conditions.
- Associated diseases and disorders
Elevated Glyoxalase Domain Containing 4 expression links to conditions such as diabetes and neurodegenerative disorders. Changes in GLOD4 levels often correspond with disruptions in methylglyoxal metabolism and oxidative stress common in these diseases. Studies also indicate relationships among GLOD4 insulin signaling and proteins such as Glyoxalase I suggesting a connection to the metabolic disturbances found in diabetes. GLOD4's involvement in detoxification pathways also affects the pathogenesis of neurodegenerative diseases potentially influencing cell survival and neuroprotection mechanisms.
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1 product image
SDS-PAGE - Recombinant Human GLOD4 protein (ab109939)
15% SDS-PAGE analysis of 3μg ab109939.
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