JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB239555

Recombinant Human GLP-1R protein (His tag)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human GLP-1R protein (His tag) is a Human Fragment protein, in the 24 to 145 aa range, expressed in Yeast, with >90%, suitable for SDS-PAGE.

View Alternative Names

Glucagon-like peptide 1 receptor, GLP-1 receptor, GLP-1-R, GLP-1R, GLP1R

1 Images
SDS-PAGE - Recombinant Human GLP-1R protein (His tag) (AB239555)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human GLP-1R protein (His tag) (AB239555)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis with 5% enrichment gel and 15% separation gel analysis of ab239555.

Key facts

Purity

>90% SDS-PAGE

Expression system

Yeast

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P43220

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.2 - 7.4 Constituents: 10% Glycerol (glycerin, glycerine), 2.9% Sodium chloride, 0.32% Tris HCl

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"RPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLY","proteinLength":"Fragment","predictedMolecularWeight":"16.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":145,"aminoAcidStart":24,"nature":"Recombinant","expressionSystem":"Yeast","accessionNumber":"P43220","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

GLP-1R also known as glucagon-like peptide-1 receptor plays an important role in glucose metabolism. This receptor is a member of the class B family of G protein-coupled receptors (GPCRs) and has a molecular mass of approximately 53 kDa. GLP-1R is expressed in pancreatic beta cells the central nervous system and other peripheral tissues. It binds to GLP-1 a peptide hormone initiating a cascade of intracellular signaling that is essential for its physiological functions.
Biological function summary

GLP-1R serves as an important player in the regulation of insulin secretion. It is not part of a complex but acts as a standalone receptor. When GLP-1 binds to GLP-1R it triggers the activation of adenylyl cyclase increasing cyclic AMP levels and facilitating insulin secretion. This process is glucose-dependent meaning that it enhances insulin release only when blood glucose levels are elevated therefore preventing hypoglycemia.

Pathways

GLP-1R is an integral component of the incretin signaling pathway and the insulin signaling pathway. Through these pathways it influences key metabolic processes. Incretin hormones like GLP-1 improve glucose-dependent insulin secretion involving proteins such as GLP-1R and other incretin-related receptors. Additionally GLP-1R interacts with insulin receptor pathways to modulate glucose uptake in tissues.

GLP-1R has significant implications in type 2 diabetes and obesity. Its role in enhancing insulin secretion makes it a target for therapeutic interventions using GLP-1 analogs like liraglutide. Liraglutide structure mimics natural GLP-1 effectively agonizing GLP-1R to achieve desired metabolic outcomes. Additionally liraglutide GLP-1 analog therapies show promise in obesity management by influencing appetite regulation through GLP-1R pathways in the central nervous system.
style
left-column

Specifications

Form

Liquid

style
left-column

General info

Function

G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed : 19861722, PubMed : 26308095, PubMed : 27196125, PubMed : 28514449, PubMed : 7517895, PubMed : 8216285, PubMed : 8405712). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed : 19861722, PubMed : 26308095, PubMed : 27196125, PubMed : 28514449, PubMed : 7517895, PubMed : 8216285, PubMed : 8405712). Plays a role in regulating insulin secretion in response to GLP-1 (By similarity).

Sequence similarities

Belongs to the G-protein coupled receptor 2 family.

Post-translational modifications

N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER.

style
left-column

Product protocols

style
left-column

Target data

G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed : 19861722, PubMed : 26308095, PubMed : 27196125, PubMed : 28514449, PubMed : 7517895, PubMed : 8216285, PubMed : 8405712). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed : 19861722, PubMed : 26308095, PubMed : 27196125, PubMed : 28514449, PubMed : 7517895, PubMed : 8216285, PubMed : 8405712). Plays a role in regulating insulin secretion in response to GLP-1 (By similarity).
See full target information GLP1R
style
left-column
style
left-column
style
right-column

Complementary Products

Assay Kits

AB65336

Triglyceride Assay Kit - Quantification

Biochemical assay - Triglyceride Assay Kit - Quantification (AB65336)

  • 4
  • 4
Primary Antibodies

AB218532

Anti-GLP-1R antibody [EPR21819]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Frozen sections) - Anti-GLP-1R antibody [EPR21819] (AB218532)

  • 4
  • 6
Proteins & Peptides

AB235719

Recombinant Human GLP-1 protein (Tagged)

SDS-PAGE - Recombinant Human GLP-1 protein (Tagged) (AB235719)

  • 0
  • 0
Proteins & Peptides

AB276649

Recombinant Human GIP protein (Fc Chimera)

SDS-PAGE - Recombinant Human GIP protein (Fc Chimera) (AB276649)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com